pH Sensitive Drug Delivery Systems: A Review

Balamurali, V.; Pramodkuma, T.M.; Srujana, N.; Venkatesh, M. P.; Gupta, Nikhil; Krishna, K L; Gangadhara, H.V.

doi:10.3923/ajdd.2011.24.48

Cited by 108 publications

(53 citation statements)

References 72 publications

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“…Amphiphilic molecules containing a protonatable acidic group that is negatively charged at physiological pH can be incorporated alongside PE in the lipidic bilayer. These molecules allow the formation of bilayer structures and liposomes at physiological pH and temperature because, in addition to causing electrostatic repulsion between bilayers, they also disrupt the strong interactions between PE headgroups [63].…”

Section: Ph Sensitive Liposomesmentioning

confidence: 99%

Design of liposomal formulations for cell targeting

Nogueira

Gomes

Preto

et al. 2015

Colloids and Surfaces B: Biointerfaces

131

102

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Liposomes have gained extensive attention as carriers for a wide range of drugs due to being both nontoxic and biodegradable as they are composed of substances naturally occurring in biological membranes. Active targeting for cells has explored specific modification of the liposome surface by functionalizing it with specific targeting ligands in order to increase accumulation and intracellular uptake into target cells. None of the Food and Drug Administration-licensed liposomes or lipid nanoparticles are coated with ligands or target moieties to delivery for homing drugs to target tissues, cells or subcellular organelles. Targeted therapies (with or without controlled drug release) are an emerging and relevant research area. Despite of the numerous liposomes reviews published in the last decades, this area is in constant development. Updates urgently needed to integrate new advances in targeted liposomes research. This review highlights the evolution of liposomes from passive to active targeting and challenges in the development of targeted liposomes for specific therapies.

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Section: Ph Sensitive Liposomesmentioning

confidence: 99%

Design of liposomal formulations for cell targeting

Nogueira

Gomes

Preto

et al. 2015

Colloids and Surfaces B: Biointerfaces

131

102

View full text Add to dashboard Cite

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“…For example, the pH varies widely in different parts of the gastrointestinal tract: pH 1-3 in the stomach, pH 5 in the small intestine and pH 7-8 in the colon. 2 Sites of inflammation, bacterial infections or tumors have also been found to be more acidic (∼pH 5-6.5) than physiological pH (∼pH 7.4). [18][19][20] The use of nanoparticles (NPs) in devising pH-based DDSs is appealing because of several reasons.…”

Section: Introductionmentioning

confidence: 99%

Polypyrrole nanoparticles for tunable, pH-sensitive and sustained drug release

Meiser

Zare

2015

Nanoscale

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aWe report the development of a generalized pH-sensitive drug delivery system that can release any charged drug preferentially at the pH range of interest. Our system is based on polypyrrole nanoparticles (PPy NPs), synthesized via a simple one-step microemulsion technique. These nanoparticles are highly monodisperse, stable in solution over the period of a month, and have good drug loading capacity (∼15 wt%). We show that PPy NPs can be tuned to release drugs at both acidic and basic pH by varying the pH, the charge of the drug, as well as by adding small amounts of charged amphiphiles. Moreover, these NPs may be delivered locally by immobilizing them in a hydrogel. Our studies show encapsulation within a calcium alginate hydrogel results in sustained release of the incorporated drug for more than 21 days. Such a nanoparticle-hydrogel composite drug delivery system is promising for treatment of longlasting conditions such as cancer and chronic pain which require controlled, localized, and sustained drug release.

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“…A selection of examples in drug delivery was given and a brief outlook of future aspects was provided. Balamuralidhara et al [1] published a review article on pH-sensitive drug-delivery systems and discussed several pHsensitive drug-delivery systems, including pH-sensitive hydrogels and pH-sensitive liposomes. One important strategy for realizing pH-responsive drug delivery is the formation of pH-sensitive linkages between the drug molecules and the drug carrier, such as the hydrazone linkage that exhibits excellent pH sensitivity.…”

Section: Organic-materials-based Ph-responsive Drug-delivery Systemsmentioning

confidence: 99%

“…Another strategy is to use polymers that contain weakly acidic or basic groups in the polymer backbone; variation in the pH value of the solution will cause swelling or deswelling of the polymer and in this way the drug release from these polymers will exhibit release rates that are pH-sensitive. [1] Hydrogels are an important kind of material with many applications in various biomedical fields. Gupta et al [4] reviewed the applications of hydrogels in stimuli-responsive and, in particular, pH-responsive drug delivery.…”

Section: Organic-materials-based Ph-responsive Drug-delivery Systemsmentioning

confidence: 99%

“…For example, the pH values vary in a wide range from the stomach (pH 1.5-3.5) and small intestine (pH 5.5-6.8) to the colon (6.4-7.0). [1] The pH values in tumors and inflammatory tissues are lower than those in blood and normal tissues ( % 7.4), and the acidic cellular environments exhibit even lower pH values (e.g., endosomes (pH % 5.5-6.0) and lysosomes (pH 4.5-5.0). [2] The difference in the pH value of different organs, tissues and cellular compartments may provide a suitable physiological stimulus for pH-responsive drug delivery.…”

Section: Introductionmentioning

confidence: 99%

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pH‐Responsive Drug‐Delivery Systems

Zhu

Chen

2014

Chemistry An Asian Journal

160

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In many biomedical applications, drugs need to be delivered in response to the pH value in the body. In fact, it is desirable if the drugs can be administered in a controlled manner that precisely matches physiological needs at targeted sites and at predetermined release rates for predefined periods of time. Different organs, tissues, and cellular compartments have different pH values, which makes the pH value a suitable stimulus for controlled drug release. pH-Responsive drug-delivery systems have attracted more and more interest as "smart" drug-delivery systems for overcoming the shortcomings of conventional drug formulations because they are able to deliver drugs in a controlled manner at a specific site and time, which results in high therapeutic efficacy. This focus review is not intended to offer a comprehensive review on the research devoted to pH-responsive drug-delivery systems; instead, it presents some recent progress obtained for pH-responsive drug-delivery systems and future perspectives. There are a large number of publications available on this topic, but only a selection of examples will be discussed.

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pH Sensitive Drug Delivery Systems: A Review

Cited by 108 publications

References 72 publications

Design of liposomal formulations for cell targeting

Design of liposomal formulations for cell targeting

Polypyrrole nanoparticles for tunable, pH-sensitive and sustained drug release

pH‐Responsive Drug‐Delivery Systems

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