pH-sensing hybrid hydrogels for non-invasive metabolism monitoring in tumor spheroids

Rizzo, Riccardo; Onesto, Valentina; Morello, Giulia; Iuele, Helena; Scalera, Francesca; Forciniti, Stefania; Gigli, Giuseppe; Polini, Alessandro; Gervaso, Francesca; Mercato, Loretta L. del

doi:10.1016/j.mtbio.2023.100655

Cited by 6 publications

(1 citation statement)

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“…229 Particle sensors can be easily dispersed within hydrogels, and because of their macromolecular polymer network structure and hydration, the mobility of small ions does not decrease signicantly compared to their diffusion in aqueous solutions. 230,231 Among hydrogels, alginate is a naturally occurring biopolymer that has many applications owing to its biocompatibility, low cost, ease of gelation and optical transparency, which make it highly suitable even for microscopy applications. Very recently, alginate-based three-dimensional microgels were produced using an electrostatic droplet encapsulation method to embed FITC-RBITC SiO 2 pH sensors together with pancreatic tumor and/or stromal cells (Fig.…”

Section: Hybrid Materials/systems Including Fluorescent Nano-micropar...mentioning

confidence: 99%

Fluorescent nano- and microparticles for sensing cellular microenvironment: past, present and future applications

et al. 2023

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Section: Hybrid Materials/systems Including Fluorescent Nano-micropar...mentioning

confidence: 99%

Fluorescent nano- and microparticles for sensing cellular microenvironment: past, present and future applications

et al. 2023

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Advances in sensor developments for cell culture monitoring

Kim,

Yeo

2023

BMEMat

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Cell culture encompasses procedures for extracting cells from their natural tissue and cultivating them under controlled artificial conditions. During this process, various factors, including cell physiological/morphological properties, culture environments, metabolites, and contaminants, have to be precisely controlled and monitored for the survival of cells and the pursuit of the desired properties of the cells. This review summarizes recent advances in sensor technologies and manufacturing strategies for various cell culture platforms using traditional plastics, microfluidic chips, and scalable bioreactors. We share the details of newly developed biological sensors, chemical sensors, optical sensors, electronic chip technologies, and material integration methods. The precise control of parameters based on the feedback by these sensors and electronics enhances cell culture quality and throughput.

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Colorimetric and fluorescence dual-mode pH sensor based on nitrogen-doped carbon dots and its diverse applications

Zhou,

Pang,

Wang

et al. 2023

Microchim Acta

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pH-sensing hybrid hydrogels for non-invasive metabolism monitoring in tumor spheroids

Cited by 6 publications

References 64 publications

Fluorescent nano- and microparticles for sensing cellular microenvironment: past, present and future applications

Fluorescent nano- and microparticles for sensing cellular microenvironment: past, present and future applications

Advances in sensor developments for cell culture monitoring

Colorimetric and fluorescence dual-mode pH sensor based on nitrogen-doped carbon dots and its diverse applications

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