Fluorescent nano- and microparticles for sensing cellular microenvironment: past, present and future applications

Abstract

Summary of advances in synthesis and application of optical ratiometric nano- and microparticle sensors for in vitro and in vivo detection of pH, oxygen, ROS, ions, and biomarkers in cell microenvironment.

Exploring the fluorescence properties of tellurium-containing molecules and their advanced applications

“…10 This process is a potent analytical technique that utilizes the distinctive properties of fluorescent molecules to yield valuable insights into the composition, structure, and dynamics of various substances. [11][12][13][14] Fluorescence techniques, renowned for their remarkable versatility, play an indispensable role in advancing biomedical research. Their prowess extends to investigating molecular interactions, [15][16][17] decoding cellular processes, [18][19][20] and identifying crucial biomarkers.…”

A collagen-immobilized nanodevice for in situ ratiometric imaging of cancer biomarkers in the tumor microenvironment

“…25 In contrast, ratiometric measurements can minimize nonspecic effects by selfcalibrating the signal intensity, thereby increasing the sensitivity and reliability of detection. [26][27][28] Nevertheless, developing a ratiometric uorescent reporter for real-time monitoring and in situ imaging of cancer biomarkers in the TME remains a signicant challenge due to the lack of molecular targeting tools with high affinity, stability, and versatility in the TME.…”

Acoustofluidics-Assisted Coating of Microparticles

“…Microparticles have been utilized in many areas such as drug delivery [1], diagnostics [2], cosmetics, personal care [3], the food industry [4], chemical and catalytic reactions [5], sensing [6], and environmental remediation [7]. Coating further provides additional functionality to the microparticles such as controlled release, surface modification, bio-fouling resistance, stability, protection, etc.…”