A collagen-immobilized nanodevice for in situ ratiometric imaging of cancer biomarkers in the tumor microenvironment

Abstract

Monitoring the spatiotemporal dynamics of cancer biomarkers within the tumor microenvironment (TME) is critical to understanding their roles in tumorigenesis. Here, we reported a multifunctional fusion protein (collagen-binding domain and...

A “dual-key-and-lock” DNA nanodevice enables spatially controlled multimodal imaging and combined cancer therapy

“…1,2 Governed by the Watson–Crick base paring rules, DNAs with unique programmability and affordability have become unparalleled scaffolds for engineering nanodevices and molecular machines. 3,4 In particular, owing to the easy-to-predict thermodynamics and good biocompatibility, such DNA-based nanostructures have exhibited excellent performance when interacting with biological elements, which show great promise in biosensing and bioimaging, 5,6 specific cargo delivery, 7,8 molecule computation, 9–11 and so on. Despite the progress made, the majority of current DNA nanodevices still operate in an “always on” model.…”