pH-responsive silk fibroin-based CuO/Ag micro/nano coating endows polyetheretherketone with synergistic antibacterial ability, osteogenesis, and angiogenesis

Yan, Jianglong; Xia, Dandan; Zhou, Wenhao; Li, Yangyang; Xiong, Pan; Li, Qiyao; Wang, Pei; Li, Ming; Zheng, Yufeng; Cheng, Yan

doi:10.1016/j.actbio.2020.07.062

Cited by 95 publications

(64 citation statements)

References 56 publications

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“…The fast coverage of the nano-textured titanium by human mesenchymal stem cells together with stimulation of bony differentiation could decrease the chance of biofilm formation during implant integration with the human bone tissue [101]. Ag NPs coupled with polyetheretherketone have been developed for osteogenesis and angiogenesis in addition to the antibacterial ability [102]. Copper-incorporating mesoporous bioactive glass NPs have been invented for bone regeneration as well as antimicrobial ability [103].…”

Section: Support Of Tissue Regeneration In Biofilmsmentioning

confidence: 99%

Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases

et al. 2021

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Bacteria-targeting nanomaterials have been widely used in the diagnosis and treatment of bacterial infectious diseases. These nanomaterials show great potential as antimicrobial agents due to their broad-spectrum antibacterial capacity and relatively low toxicity. Recently, nanomaterials have improved the accurate detection of pathogens, provided therapeutic strategies against nosocomial infections and facilitated the delivery of antigenic protein vaccines that induce humoral and cellular immunity. Biomaterial implants, which have traditionally been hindered by bacterial colonization, benefit from their ability to prevent bacteria from forming biofilms and spreading into adjacent tissues. Wound repair is improving in terms of both the function and prevention of bacterial infection, as we tailor nanomaterials to their needs, select encapsulation methods and materials, incorporate activation systems and add immune-activating adjuvants. Recent years have produced numerous advances in their antibacterial applications, but even further expansion in the diagnosis and treatment of infectious diseases is expected in the future.

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Section: Support Of Tissue Regeneration In Biofilmsmentioning

confidence: 99%

Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases

et al. 2021

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“…Endogenously Triggered Nanocatalysts: As bacterial metabolism acidifies its environment, [221] Yan et al constructed pH-responded SP-CuO/Ag nanoagents, which were copper oxide microspheres ( CuO) decorated with silver nanoparticles (nAg) on a porous polyetheretherketone (PEEK) surface via silk fibroin (SF). [222] Different parts of the SF backbone had different isoelectric points, resulting in changes in its charge and molecular conformation as pH changes. High concentrations of metal ions are needed for efficient sterilization in low pH environments, and low concentrations are needed for bone formation under physiological environment (pH 7.4) (Figure 5a).…”

Section: Nanocatalystsmentioning

confidence: 99%

“…b) Morphology of E. coli observed under SEM after incubation with different samples at different pH for 6 h. Adapted with permission. [ 222 ] Copyright 2020, Elsevier. c) The light excited antibiotic producing ROS potentiated the bacteria death.…”

Section: Applications In Nanomedicinementioning

confidence: 99%

Which is Better for Nanomedicines: Nanocatalysts or Single‐Atom Catalysts?

Zhao

Zhang

Yang

et al. 2020

Adv Healthcare Materials

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With the rapid advancements in nanotechnology and materials science, numerous nanomaterials have been used as catalysts for nanomedical applications. Their design and modification according to the microenvironment of diseases have been shown to achieve effective treatment. Chemists are in pursuit of nanocatalysts that are more efficient, controllable, and less toxic by developing innovative synthetic technologies and improving existing ones. Recently, single-atom catalysts (SACs) with excellent catalytic activity and high selectivity have attracted increasing attention because of their accurate design as nanomaterials at the atomic level, thereby highlighting their potential for nanomedical applications. In this review, the recent advances in nanocatalysts and SACs are briefly summarized according to their synthesis, characterizations, catalytic mechanisms, and nanomedical applications. The opportunities and future scope for their development and the issues and challenges for their application as nanomedicine are also discussed. As far as it is known, the review is the systematic comparison of nanocatalysts and SACs, especially in the field of nanomedicine, which has promoted the development of nanocatalytic medicine.

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“…Therefore, aside from immunomodulation, the PEEK implant also needs improved antibacterial ability to combat potential infection and reduce the risk of implant loosening especially in surgical areas trapped by bacterial infections. The use of copper nanoparticles (Liu et al., 2019 ), zinc layer (Liu et al., 2018 ), or silver particles (Yan et al., 2018 ) or the composite of CuO/Ag (Yan et al., 2020 ) on porous PEEK is fabricated to improve the antibacterial ability of implant. However, the potential toxicological effects of metal ions may bring serious damage (Schrand et al., 2010 ; Makhdoumi et al., 2020 ), which limits the application prospects.…”

Section: Introductionmentioning

confidence: 99%

Facile surface functional polyetheretherketone with antibacterial and immunoregulatory activities for enhanced regeneration toward bacterium-infected bone destruction

et al. 2021

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Existing biologically inert or unmodified implants to treat infectious bone defects or osteomyelitis still cannot effectively solve bacterial infection and osseointegration. In this work, a simple co-deposition strategy was developed to modify porous polyetheretherketone (PEEK) with improved antibacterial activity and controllable immunoregulatory ability. After PEEK was treated by H 2 SO 4 to obtain porous PEEK (SPEEK), the self-polymerization of dopamine was operated on SPEEK in the solution of dopamine and gentamicin sulfate (GS) to prepare polydopamine (pDA) and GS layer-modified SPEEK (labeled as SPEEK–pDA–GS). The morphology, surface property, and molecular structure of SPEEK–pDA–GS were investigated. Besides the antibacterial property of SPEEK–pDA–GS ascribed to the successful immobilization of GS, SPEEK–pDA–GS exhibited promoted osseointegration through the results of mineralization, alkaline phosphatase (ALP) levels and osteogenic gene expression. Furthermore, the evaluation of the cell proliferation suggested that SPEEK–pDA–GS possessed the biocompatibility and the immunoregulatory ability that induced macrophages to anti-inflammatory M2 phenotype. Using rat as model, in vivo results containing X-ray, μ-CT, immunohistochemistry, and pathological analysis showed the excellent healing effect of SPEEK–pDA–GS on bone defect with infection with biological safety. This work illustrates a new insight into the simple and effective modification of PEEK and other implants with antibacterial, immunoregulatory, and osseointegration abilities for clinical requirement.

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pH-responsive silk fibroin-based CuO/Ag micro/nano coating endows polyetheretherketone with synergistic antibacterial ability, osteogenesis, and angiogenesis

Cited by 95 publications

References 56 publications

Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases

Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases

Which is Better for Nanomedicines: Nanocatalysts or Single‐Atom Catalysts?

Facile surface functional polyetheretherketone with antibacterial and immunoregulatory activities for enhanced regeneration toward bacterium-infected bone destruction

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