pH-responsive polymeric vesicles from branched copolymers

Zhou, Jinglun; Li, Linlin; Wang, Weishan; Zhao, Yang; Feng, Shengyu

doi:10.1039/c9ra08703f

Cited by 3 publications

(2 citation statements)

References 39 publications

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“…The former mainly includes polylactic acid (PLA), poly(butyleneadipate-co-terephthalate) (PBAT), modified starch, polybutylene succinate (PBS), etc. [ 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. The main materials that can be decomposed in the natural environment are made by compounding polyolefin materials, such as polyethylene (PE), polypropylene (PP) and degrading additives.…”

Section: Introductionmentioning

confidence: 99%

Study on Rapid Detection Method for Degradation Performance of Polyolefin-Based Degradable Plastics

Zhou

Wang

et al. 2022

Polymers

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In order to accurately determine the degradation performance of polyolefin-based degradable plastics, the concept of bioassimilated carbon is proposed for the first time in this paper; the bioactive and hydrophilic organic carbon in plastic degradation products is defined as bioassimilation carbon. A method for the detection of the carbonyl index and bioassimilated carbon conversion rate in polyolefin degradable plastics was developed to quickly identify its degradation performance. The measurement results show that the bioassimilated carbon conversion rate of more than 70% can be used to replace the biodegradation rate index to achieve the purpose of quickly identifying the degradation performance of plastics. The deterioration detection cycle proposed by the current common standards implemented in American Society of Testing Materials: ASTM D6400 “Specification for Composting Plastics” can be shortened from 1 year to 1 month. The standard system for catalytic degradation of plastics provides detection methods for polyolefin-based catalytic degradation materials (microplastics), and solves the problems of long detection cycle and poor detection efficiency. Thus, this method has promise for use as a relevant standard method for accurately providing a reference for the assessment.

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Section: Introductionmentioning

confidence: 99%

Study on Rapid Detection Method for Degradation Performance of Polyolefin-Based Degradable Plastics

Zhou

Wang

et al. 2022

Polymers

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“…sites such as tumors, microenvironment acidification is caused, the application of amino and tertiary amines in the field of drug carriers are promising. [43][44][45] Lang and co-workers successfully grafted amine-terminated ploy(N-isopropylacrylamide) onto poly(2-oxepane-1,5-dione-co-ɛ-caprolactone) to achieve the selfassembled core-shell micelles with biodegradability, thermal response, and pH-response properties. [46] Chen et al successfully developed poly(ethylene glycol)-b-(poly(2-(diethylamino)ethyl methacrylate)-b-poly(hydroxyethyl methacrylate)-g-folic acid) 2 [PEG-b-(PDEAEMA-b-PHEMA-g-FA) 2 ] as a drug carrier, and achieved pH responsiveness owing to the protonation of the tertiary amino groups under acidic conditions.…”

Section: Introductionmentioning

confidence: 99%

Hypoxia/Temperature/pH Triple Stimuli–Responsive Block Copolymers: Synthesis, Self‐Assembly, and Controlled Drug Release

Deng

Yuan

et al. 2021

Macro Materials & Eng

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The amphiphilic block copolymer poly(methacrylic acid-co-2-nitroimidazole acrylate)-b-poly(2-(N,N-dimethylamino)ethyl methacrylate) (P(MAA-co-NIMA)-b-PDMAEMA) with the hypoxia/temperature/pH triple responsiveness is synthesized by reversible addition-fragmentation chain transfer polymerization (RAFT), hydrolysis, and 3-(3-dimethylaminopropyl)-1-ethylcarbodiimide (EDC) reactions, and successfully self-assembled into micelles. The hypoxia response in vitro is realized, and then the sensitivity of the self-assembled micelles to the hypoxia condition is studied by controlling the grafting amount of aminated 2-nitroimidazole. Because 2-(N,N-dimethylamino) ethyl methacrylate (DMAEMA) is a typical material sensitive to temperature and pH conditions, the self-assembled micelles are also responsive to temperature and different acidic/basic conditions. In addition, the cumulative release rate of doxorubicin (DOX) at 42°C, pH = 6.0, and hypoxic conditions increases significantly, and verifies the synergistic promotion effect of the above stimulations. This intelligent polymer with triple response mechanism improves the controllability and efficiency of drug release, and is expected to be a drug carrier for cancer treatment.

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Synthetic peptide branched polymers for antibacterial and biomedical applications

Shabani,

Hadjigol,

et al. 2024

Nat Rev Bioeng

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pH-responsive polymeric vesicles from branched copolymers

Abstract: A new type of branched copolymer, poly(l-lactide)2-b-poly(l-glutamic acid), based on polypeptide PLGA is synthesized by the ring-opening polymerization of N-carboxyanhydride of γ-benzyl-l-glutamate with amino-terminated PLLA2–NH2 and subsequent deprotection.

Cited by 3 publications

References 39 publications

Study on Rapid Detection Method for Degradation Performance of Polyolefin-Based Degradable Plastics

Study on Rapid Detection Method for Degradation Performance of Polyolefin-Based Degradable Plastics

Hypoxia/Temperature/pH Triple Stimuli–Responsive Block Copolymers: Synthesis, Self‐Assembly, and Controlled Drug Release

Synthetic peptide branched polymers for antibacterial and biomedical applications

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