Synthetic peptide branched polymers for antibacterial and biomedical applications

Shabani, Sadegh; Hadjigol, Sara; Li, Wenyi; Si, Zhangyong; Pranantyo, Dicky; Chan-Park, Mary B.; O’Brien-Simpson, Neil M.; Qiao, Greg G.

doi:10.1038/s44222-023-00143-4

Cited by 7 publications

(1 citation statement)

References 197 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides, developing peptide-based nanocomplexes for intramuscular vaccine delivery ( e.g. , mRNA and spike proteins) is intriguing, which in fact requires activation of immune responses post-treatment . For the protein-dressed P/Si, how to promote endosomal escape is crucial for ultimate RNAi efficacy.…”

Section: Discussionmentioning

confidence: 99%

Engineering Biomimetic Protein Camouflage for Delivering Peptide/siRNA Nanocomplexes

Wang,

Chen

2024

J. Am. Chem. Soc.

View full text Add to dashboard Cite

For cationic nanoparticles, the spontaneous nanoparticle–protein corona formation and aggregation in biofluids can trigger unexpected biological reactions. Herein, we present a biomimetic strategy for camouflaging the cationic peptide/siRNA nanocomplex (P/Si) with single or dual proteins, which exploits the unique properties of endogenous proteins and stabilizes the cationic P/Si complex for safe and targeted delivery. An in-depth study of the P/Si protein corona (P/Si-PC) formation and protein binding was conducted. The results provided insights into the biochemical and toxicological properties of cationic nanocomplexes and the rationales for engineering biomimetic protein camouflages. Based on this, the human serum albumin (HSA) and apolipoprotein AI (Apo-AI) ranked within the top 20 abundant protein species of P/Si-PC were selected to construct biomimetic HSA-dressed P/Si (P/Si@HSA) and dual protein (HSA and Apo-AI)-dressed P/Si (P/Si@HSA_Apo), given that the dual-protein camouflage plays complementary roles in efficient delivery. A branched cationic peptide (b-HKR) was tailored for siRNA delivery, and their nanocomplexes, including the cationic P/Si and biomimetic protein-dressed P/Si, were produced by a precise microfluidic technology. The biomimetic anionic protein camouflage greatly enhanced P/Si biostability and biocompatibility, which offers a reliable strategy for overcoming the limitation of applying cationic nanoparticles in biofluids and systemic delivery.

show abstract

Section: Discussionmentioning

confidence: 99%

Engineering Biomimetic Protein Camouflage for Delivering Peptide/siRNA Nanocomplexes

Wang,

Chen

2024

J. Am. Chem. Soc.

View full text Add to dashboard Cite

show abstract

Polymer–drug and polymer–protein conjugated nanocarriers: Design, drug delivery, imaging, therapy, and clinical applications

Guo,

2024

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

Polymer–drug conjugates and polymer–protein conjugates have been pivotal in the realm of drug delivery systems for over half a century. These polymeric drugs are characterized by the conjugation of therapeutic molecules or functional moieties to polymers, enabling a range of benefits including extended circulation times, targeted delivery, controlled release, and decreased immunogenicity. This review delves into recent advancements and challenges in the clinical translations and preclinical studies of polymer–drug conjugates and polymer–protein conjugates. The design principles and functionalization strategies crucial for the development of these polymeric drugs were explored followed by the review of structural properties and characteristics of various polymer carriers. This review also identifies significant obstacles in the clinical translation of polymer–drug conjugates and provides insights into the directions for their future development.This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

show abstract

Polymer-Based Antimicrobial Peptide Mimetics for Treating Multi-drug Resistant Infections: Therapy and Toxicity Evaluation

Harini,

Girigoswami,

Thirumalai

et al. 2024

Int J Pept Res Ther

View full text Add to dashboard Cite

Synthetic peptide branched polymers for antibacterial and biomedical applications

Cited by 7 publications

References 197 publications

Engineering Biomimetic Protein Camouflage for Delivering Peptide/siRNA Nanocomplexes

Engineering Biomimetic Protein Camouflage for Delivering Peptide/siRNA Nanocomplexes

Polymer–drug and polymer–protein conjugated nanocarriers: Design, drug delivery, imaging, therapy, and clinical applications

Polymer-Based Antimicrobial Peptide Mimetics for Treating Multi-drug Resistant Infections: Therapy and Toxicity Evaluation

Contact Info

Product

Resources

About