pH-responsive polymeric nanoparticles with tunable sizes for targeted drug delivery

Abstract

Novel nanoparticles for efficient drug delivery were designed and constructed using polymeric 2,3-dialdehyde cellulose (DAC). The drug DOX was encapsulated into nanoparticles and underwent thoroughly controlled release in acidic tumor microenvironments.

Brief Outlook on Polymeric Nanoparticles, Micelles, Niosomes, Hydrogels and Liposomes: Preparative Methods and Action

“…Doxorubicin was encapsulated in this system and showed higher stability in the alkaline and neutral medium and also observed controlled release behavior of an antitumor agent. [132] The journey of nanocarriers starts from Doxil, the clinically approved liposomal doxorubicin and liposomal drug delivery system is more advantageous than others due to its safety and effectiveness. [133,134] The systems under clinical trial include Dauno Xaume, Mayocet, Marqibo, Mepact, Abelcet, Amphotec, DepoDur, Exparal, EpaXal, Inflexal, etc.…”

Review of the Mechanism of Nanocarriers and Technological Developments in the Field of Nanoparticles for Applications in Cancer Theragnostics

“…Another issue that plagues the reputation of nanoparticle-administered drug delivery is the biocompatibility of the nanoparticles. In research, the in vitro evaluation of the nanoparticle’s cytotoxicity to A549 cells was conducted with the help of CCK-8 analysis . It was concluded that since the derivatives of cellulose are nontoxic, biocompatible, stable, and hydrophilic, the NPs did not show any toxicity toward A549 cells (Figure b).…”

“…(c) Viability of the cells was plotted against the different dosages of DOX. Reproduced with permission from ref . Copyright 2020 The Royal Society of Chemistry.…”

Exploiting recent trends for the synthesis and surface functionalization of mesoporous silica nanoparticles towards biomedical applications

“…These agents are mainly categorized as organic or inorganic nanocarriers and brought tremendous achievement in treating various infectious diseases. These organic nanometric agents include different polymeric agents ( Begines et al, 2020 ; Kong et al, 2020 ; Palanikumar et al, 2020 ; Siddiqui et al, 2020 ), lipid-based carriers ( Barkat et al, 2020 ; Plaza-Oliver et al, 2021 ), dendrimers ( Mandal, 2021 ; Nikzamir et al, 2021 ) and micelles ( Atanase, 2021 ; Hwang et al, 2020 ). These agents are widely employed for the treatment of various dreadful diseases.…”