pH-responsive polymeric micelles based on poly(2-ethyl-2-oxazoline)-poly(d,l-lactide) for tumor-targeting and controlled delivery of doxorubicin and P-glycoprotein inhibitor

The effect of dual-functional hyaluronic acid-vitamin E succinate micelles on targeting delivery of doxorubicin

“…Nanotechnology-based drug delivery system acts as an effective strategy to circumvent MDR by bypassing P-glycoprotein (P-gp) efflux, improving anticancer efficacy, and reducing the side effects of chemotherapeutic drugs. 1,2 In particular, self-assembled polymeric micelles (PMs) have emerged as promising vehicles for drug delivery in cancer therapy. PMs have a typical core-shell structure, where hydrophobic drugs can be solubilized and stabilized in the hydrophobic inner core of the micelles, and the hydrophilic outer shell can extend the circulation time and improve the steric stabilization by reducing opsonization in blood circulation.…”

Preparation of pH-responsive asymmetric polysulfone ultrafiltration membranes with enhanced anti-fouling properties and performance by incorporating poly(2-ethyl-2-oxazoline) additive

“…The change in water ux of the membrane may be attributed to the change in hydrogen bonding reactions between the PEOX chains and water. When the pH value is low, the amide groups in PEOX are ionized, 30,31,49 and the PEOX molecular chains may aggregate via intermolecular hydrogen bonds. So, the hydrogen bonding between the PEOX chains and water becomes weak.…”

Biological responses to nanomaterials: understanding nano-bio effects on cell behaviors

“…Different nanomaterials that achieve controlled release of bioactive drugs have been reported for cancer therapy and tissue engineering (Colson & Grinstaff, 2012;Oliveira et al, 2010;Li et al, 2015b;Miguez-Pacheco et al, 2015;Zhao et al, 2015). Among them, hydroxyapatite (HA) has similar chemical and crystallographic structures with the inorganic components of bone in vivo (25-50 nm in length and 2-5 nm thick) (Olsztaa et al, 2007).…”