pH responsive N-succinyl chitosan/Poly (acrylamide-co-acrylic acid) hydrogels and in vitro release of 5-fluorouracil

Bashir, Shahid; Teo, Yin Yin; Naeem, Sumaira; Ramesh, S.

doi:10.1371/journal.pone.0179250

Cited by 75 publications

(49 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This statement was validated on Human Embryonic Kidney cells (Hek293) and the results revealed an improvement of solubility and disponibility, and no significant cytotoxicity. Cross-linking reactions between CS, COS, or CS derivatives with other polymers, synthetic and/or natural oligo-or polymers, open the way to unlimited applications, as reported by many authors, with recent examples for pectin [189], poly-γ-glutamic acid (γ-PGA) [190], Poly(ethylene glycol) (PEG) and cyclodextrin [191,192], C-phycocyanin [193], or Poly(acrylamide-co-acrylic acid) [194]. Finally, CS users interested in biomedical and pharmaceutical applications should keep in mind that the possibilities of design are unlimited, obviously maintaining the essential physicochemical, biocompatibility, biodegradability, and biosolubility properties (in particular in vivo).…”

Section: Biomedical and Pharmaceutical Functionsmentioning

confidence: 99%

Modification of Chitosan for the Generation of Functional Derivatives

et al. 2019

View full text Add to dashboard Cite

Today, chitosan (CS) is probably considered as a biofunctional polysaccharide with the most notable growth and potential for applications in various fields. The progress in chitin chemistry and the need to replace additives and non-natural polymers with functional natural-based polymers have opened many new opportunities for CS and its derivatives. Thanks to the specific reactive groups of CS and easy chemical modifications, a wide range of physico-chemical and biological properties can be obtained from this ubiquitous polysaccharide that is composed of β-(1,4)-2-acetamido-2-deoxy-d-glucose repeating units. This review is presented to share insights into multiple native/modified CSs and chitooligosaccharides (COS) associated with their functional properties. An overview will be given on bioadhesive applications, antimicrobial activities, adsorption, and chelation in the wine industry, as well as developments in medical fields or biodegradability.

show abstract

Section: Biomedical and Pharmaceutical Functionsmentioning

confidence: 99%

Modification of Chitosan for the Generation of Functional Derivatives

et al. 2019

View full text Add to dashboard Cite

show abstract

“…3A-CHI) remains in NSC FT-IR spectrum, and the formation of new FT-IR peaks at 1401 cm −1 (-COO − ions) P8 and 1552 cm −1 (-NH-) P9 , as well as the vanishing of the peak at 1566 cm −1 , indicate the proper synthesis of the NSC (Fig. 3A-NSC) 31 . In the next step, which links PAP with NSC, PAP was first derivatized to PAPE and later to PAPESE.…”

Section: Resultsmentioning

confidence: 90%

“…); IR (KBr): 3355 cm −1 (-OH) P1 , 2863 cm −1 (-CH-) P2 , 1645 cm −1 (-CO-NH-) P3 1575 cm −1 (-NH 2 ) P4 , 1150 cm −1 (-C-O-C-) P5 , 1026 cm −1 (-C-O-) P6 and 891 (pyranoid ring) P7 (Fig. 3A-CHI) 17,30,31 (Fig. S1E,f, S.I.…”

Section: Characterization and Detailed Spectral Data Of The Pnsc Syntmentioning

confidence: 99%

Photosensitive nanocarriers for specific delivery of cargo into cells

Mena-Giraldo

Pérez-Buitrago

Londoño-Berrio

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Nanoencapsulation is a rapidly expanding technology to enclose cargo into inert material at the nanoscale size, which protects cargo from degradation, improves bioavailability and allows for controlled release. Encapsulation of drugs into functional nanocarriers enhances their specificity, targeting ability, efficiency, and effectiveness. Functionality may come from cell targeting biomolecules that direct nanocarriers to a specific cell or tissue. Delivery is usually mediated by diffusion and erosion mechanisms, but in some cases, this is not sufficient to reach the expected therapeutic effects. This work reports on the development of a new photoresponsive polymeric nanocarrier (PNc)-based nanobioconjugate (NBc) for specific photo-delivery of cargo into target cells. We readily synthesized the PNcs by modification of chitosan with ultraviolet (UV)-photosensitive azobenzene molecules, with Nile red and dofetilide as cargo models to prove the encapsulation/release concept. The PNcs were further functionalized with the cardiac targeting transmembrane peptide and efficiently internalized into cardiomyocytes, as a cell line model. Intracellular cargo-release was dramatically accelerated upon a very short UV-light irradiation time. Delivering cargo in a time-space controlled fashion by means of NBcs is a promising strategy to increase the intracellular cargo concentration, to decrease dose and cargo side effects, thereby improving the effectiveness of a therapeutic regime. Functional nanocarriers for intracellular drug delivery are systems ideally composed of biodegradable and biocompatible materials such as natural polymers, lipids, amphiphilic polymers, among others, assembled with cell-targeting biomolecules (CTBs) 1,2. Nanocarriers can be designed for transporting a variety of cargo, either encapsulated into, adsorbed at, or dispersed with the nanocarriers 3. Encapsulation of therapeutic agents into nanocarriers protects them from degradation, improves their solubility and bioavailability, and enhances the efficiency and effectiveness of therapeutic regimens. However, nanocarrier systems have shown some limitations related to storage stability and administration route, because they are susceptible to aggregation and early degradation 4. Biodistribution may be also unspecific, generating inefficient therapies, side effects, genetic damage or mutations. To solve these issues, apart from carboxylic, amino, poly(ethylene glycol) and poly(phosphoester) moieties that can be placed at the outermost nanocarrier surface to confer a stealth effect, they can be functionalized with specific CTBs for site-specific controlled cargo release 5-7. Targeting ability and specificity of the resultant NBcs allows them to accumulate in the target cell or tissue at higher concentrations compared to nanoparticles without activity, thus reducing doses, frequency, toxicity and potential adverse effects that most drugs intrinsically have 8,9. Whereas the small size of NBcs, which are commonly less than 200 nm for biomedical applications 10,1...

show abstract

“…Some of the properties that are improved by chemical modification are the organic solubility, antioxidant and antibacterial properties, gene carrier ability, wound healing, controlled release of drugs, and cell adhesion . Different methods used for the derivatization of CS include sulfonation, alkylation, carboxymethylation, benzoylation, succinylation, graft copolymerization, and quaternization . Morimoto et al .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of a novel organosoluble, biocompatible, and antibacterial chitosan derivative for biomedical applications

Rizwan

Yahya

Hassan

et al. 2017

J of Applied Polymer Sci

View full text Add to dashboard Cite

Electrospun materials have a number of applications in the tissue engineering field. However, the limited solubility of chitosan (CS), especially in organic solvents, makes its electrospinning with other synthetic organosoluble polymers impossible. In this article, we report the synthesis of a novel organosoluble derivative of CS through the application of a simple synthetic methodology. CS was reacted with 1,3‐diethyl‐2‐thiobarbituric acid (DETBA) with triethylorthoformate in the presence of methanol and acetic acid (4:1). The functional groups in the synthesized materials were confirmed by Fourier transform infrared and solid‐state NMR spectroscopy, whereas X‐ray diffraction revealed the level of crystallinity. The CS derivative (CS–DETBA) was tested for its cytotoxic effects on human gastric adenocarcinoma AGS cells and was found to be nontoxic. The prepared derivative showed a much enhanced inhibitory effect on the growth of three bacterial strains, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, over that of CS itself. Overall, CS–DETBA showed good solubility in a range of organic solvents, such as dimethyl sulfoxide and N,N‐dimethylformamide, and was blended with polycaprolactone (PCL) to form films and electrospun nanofibers. The morphologies of the synthesized materials were analyzed by field emission scanning electron microscopy, and the fiber diameter was 360 nm under optimum conditions. This study demonstrated that the CS–DETBA–PCL blend could be a potential material for tissue engineering and biomedical applications. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45905.

show abstract

pH responsive N-succinyl chitosan/Poly (acrylamide-co-acrylic acid) hydrogels and in vitro release of 5-fluorouracil

Cited by 75 publications

References 75 publications

Modification of Chitosan for the Generation of Functional Derivatives

Modification of Chitosan for the Generation of Functional Derivatives

Photosensitive nanocarriers for specific delivery of cargo into cells

Synthesis of a novel organosoluble, biocompatible, and antibacterial chitosan derivative for biomedical applications

Contact Info

Product

Resources

About