pH-responsive injectable hydrogels with mucosal adhesiveness based on chitosan-grafted-dihydrocaffeic acid and oxidized pullulan for localized drug delivery

Chen

et al. 2020

Adv Materials Inter

Wood adhesives fabricated from biomass can substitute formaldehyde‐based ones, reducing the consumption of fossil resources and eliminating formaldehyde pollution. In this study, a novel and sustainable water‐soluble soybean polysaccharide (WSSPS)‐based adhesive is designed. Specifically, a hyperbranched aminated polysaccharide (HBPA–g–WSSPS), as an adhesive matrix, is synthesized via grafting reaction between oxidized WSSPS and hyperbranched polyamide (HBPA). Triglycidylamine, a bio‐based epoxide cross‐linker, reacted with the HBPA–g–WSSPS to afford a cross‐linked hyperbranched network, providing strong cohesion for the adhesive. Additionally, polyacrylamide imparted an adjustable viscosity to the adhesive. The resultant WSSPS‐based adhesive enhanced the wet shear strength of plywood (1.24 MPa) by 49% compared to the E0‐level industrial‐use melamine‐urea‐formaldehyde (MUF) resin and by 26% compared to the industrial‐use soybean meal/polyamidoamine‐epichlorohydrin (PAE) adhesive. In addition, the adhesive has characteristics similar to those of the MUF resin, including viscosity, coating performance, hot‐pressing conditions, and dry bond strength, which are superior to those of the soybean meal/PAE adhesive. This developed polysaccharide‐based adhesive can potentially enhance various composites and can be used in industrial sectors.

Section: Resultsmentioning

confidence: 54%

A High‐Performance Bio‐Adhesive Using Hyperbranched Aminated Soybean Polysaccharide and Bio‐Based Epoxide

Chen

et al. 2020

Adv Materials Inter

“…This indicated that pH-responsive self-healing injectable hydrogels can be excellent candidates for carriers for liver cancer drugs. Liang et al (2019) developed a series of multifunctional injectable pH-responsive hydrogel based on chitosan-grafted dihydrocaffeic acid (CS-DA) and oxidized amylopectin (OP) via Schiff base reaction. These hydrogels exhibited good injectability, suitable gelation time, in vitro pH-dependent equilibrated swelling ratios, morphologies, rheological characteristics, and desirable in vitro pH-sensitive drug release behavior.…”

Section: Ph-sensitive In Situ Hydrogelmentioning

confidence: 99%

Research progress in the application of in situ hydrogel system in tumor treatment

Wei

Yin

et al. 2020

Drug Delivery

The in situ hydrogel drug delivery system is a hot research topic in recent years. Combining both properties of hydrogel and solution, in situ hydrogels can provide many advantages for drug delivery application, including easy application, high local drug concentration, prolonged drug retention time, reduced drug dose in vivo, good biocompatibility and improved patient compliance, thus has potential in tumor treatment. In this paper, the related literature reports in recent years were reviewed to summarize and discuss the research progress and development prospects in the application of in situ hydrogels in tumor treatment. ARTICLE HISTORY

“…Chitosan-grafted-dihydrocaffeic acid and oxidized pullulan hydrogels via a Schiff base reaction for local doxorubicin delivery [130] 2-chloro-N,N-diethylethylamine hydrochloride/chitosan pH-responsive nanoparticles as quercetin delivery system for breast cancer treatment [131] pH-responsive Carboxymethyl chitosan nanoparticles for doxorubicin hydrochloride controlled release at pH 4.5 [132] Injectable visible light-cured glycol chitosan hydrogel incorporating paclitaxel-/β-cyclodextrin inclusion complex for ovarian cancer therapy [133] Methyl methacrylate modified chitosan conjugate by a green method via Michael addition in curcumin delivery [134] Gene Delivery…”

Section: Tissue Engineeringmentioning

confidence: 99%

Chitin and Chitosans: Characteristics, Eco-Friendly Processes and Applications in Cosmetic Science

Casadidio

Peregrina

Gigliobianco

et al. 2019

Preprint

Huge amounts of chitin and chitosans can be found in the biosphere as important constituent of the exoskeleton of many organisms, as well as waste by worldwide seafood companies. Nowadays, politicians, environmentalists, and industrialists encouraged the use of these marine polysaccharides as renewable source, particularly when developed by alternative eco-friendly processes, especially in the production of regular cosmetics. The aim of this review is to outline the physicochemical and biological properties and the different bioextraction methods of chitin and chitosans sources, focusing on enzymatic deproteinization, bacteria fermentation, and enzymatic deacetylation methods. Thanks to their biodegradability, non-toxicity, biocompatibility, and bioactivity, the application of these marine polymers is widely used in the contemporary manufacturing of biomedical and pharmaceutical products. In the end, advanced cosmetic products based on chitin and chitosans are presented, analyzing different therapeutic aspects about skin, hair, nail, and oral care. The innovative formulations described can be considered as excellent solutions regarding problems in the various body anatomical sectors.