pH-Responsive doxorubicin delivery using shear-thinning biomaterials for localized melanoma treatment

Abstract

Injectable shear-thinning biomaterials (STBs) have attracted significant attention because of their efficient and localized delivery of cells as well as various molecules ranging from growth factors to drugs. Recently, electrostatic...

Locally controlled release of immunosuppressive promotes survival of transplanted adult spinal cord tissue

“…MMPs) and the release of TAC. To determine whether TAC@TGM could be easily delivered to target site, we measured the injection force at various injection conditions (a 1 cc syringe or 2.5 cc syringe with different sizes of needle, 18G, 23G and 25G) by referring to the method of Lee et al [ 31 ]. The TAC@TGM could be injected stably and exhibited varying levels of injection force with different syringe sizes.…”

Thermoresponsive shear-thinning hydrogel (T-STH) hemostats for minimally invasive treatment of external hemorrhages

“…46,47 Our lab, specifically, has developed shear-thinning hydrogels from porcine gelatin and LAPONITE® as embolic agents and drug delivery systems for the treatment hepatocellular carcinoma. 32,34,48,49 Inspired by our previous research, in this study, we engineered thermoresponsive hydrogels composed of p(NIPAM) and LAPONITE®. We wanted to take advantage of the thermoresponsive nature of p(NIPAM) to develop a reversible hemostat that would harden and form a wound plug at body temperature but could also be easily removed with a cold saline wash. Stock solution of p(NIPAM) and LAPONITE® were homogenized via vigorous agitation using a speed mixer to prevent clumping of the LAPONITE® during gelation.…”

Advances in the Application of Nanomaterials to the Treatment of Melanoma

“…Shear-thinning biomaterials (STBs) have unique mechanical properties that reduce their viscosity under shear stress and restore them to their initial value after injection. Compared to conventional chemotherapy in systemic circulation, STBs allow the targeted and sustained delivery of chemotherapeutic drugs while minimizing off-target effects [ 109 ]. Since the microenvironment of malignant tumors is acidic (~pH 5.6–6.8) [ 110 ], using pH-sensitive biomaterials for drug delivery is a good option.…”

“…A recent survey of gelatin/LAPONITE ® based on injectable STBs by Lee et al revealed that the pH responsiveness and rheological properties of melanoma-targeting STBs could be regulated by controlling the composition ratio of gelatin/LAPONITE ® , which reflects the therapeutic properties of STBs. Drugs can be delivered by personalized, highly controllable, and sustained-release mechanisms [ 109 ]. Pyrimidine analog 5-fluorouracil (5-FU) is a potent chemotherapeutic agent widely used to treat skin cancer.…”