pH-responsive biodegradable amphiphilic networks

Zednı́k, Jiřı́; Riva, Raphaël; Lussis, Perrine; Jérôme, Christine; Jérôme, Robert; Lecomte, Philippe

doi:10.1016/j.polymer.2007.12.029

Cited by 34 publications

(19 citation statements)

References 20 publications

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“…Because of this, it is always recommended to make copolymerization with monomers of greater hydrophilic or make crosslinked structures [68], the inulin crosslinking density plays and important role since crosslinking decreases PCL-diol crystallization and permits hydrolysis in amorphous sections enhancing degradation. The hydrolysis in amorphous sections facilitates drug release from PCL-diol based polymers [67,[69][70][71].…”

Section: Discussionmentioning

confidence: 99%

Synthesis and Characterization of Inulin-Based Responsive Polyurethanes for Breast Cancer Applications

et al. 2020

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In this study, new polyurethanes (PUs) were prepared by using inulin and polycaprolactone as polyols. Their structure and morphology were determined by Fourier transform infrared spectroscopy (FTIR), Raman dispersive spectroscopy, Nuclear magnetic resonance spectroscopy ( 1 H NMR and 13 C NMR), and scanning electron microscopy (SEM), whereas their mechanical properties were evaluated by a universal testing machine. Additionally, their water uptake, swelling behavior, and degradation were evaluated to be used as drug delivery carriers. Therefore, an anti-cancer drug was loaded to these PUs with 25% of loading efficiency and its release behavior was studied using different theoretical models to unveil its mechanism. Finally, the ability of the new PUs to be used as a clip marker in breast biopsy was evaluated. The results clearly demonstrate that these PUs are safe and can be used as intelligent drug release matrices for targeted drug delivery and exhibits positive results to be used for clip marker and in general for breast cancer applications.

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Section: Discussionmentioning

confidence: 99%

Synthesis and Characterization of Inulin-Based Responsive Polyurethanes for Breast Cancer Applications

et al. 2020

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“…Classical micelles of amphiphilic block copolymers have been widely studied and used for the solubilization of insoluble drugs and as carriers in drug delivery systems [1,2]. However, they are not appropriate for the storage and release of charged or hydrosoluble drugs.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical properties of pH-controlled polyion complex (PIC) micelles of poly(acrylic acid)-based double hydrophilic block copolymers and various polyamines

et al. 2012

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The physicochemical properties of polyion complex (PIC) micelles were investigated in order to characterize the cores constituted of electrostatic complexes of two oppositely charged polyelectrolytes. The pH-sensitive micelles were obtained with double hydrophilic block copolymers containing a poly(acrylic acid) block linked to a modified poly(ethylene oxide) block and various polyamines (polylysine, linear and branched polyethyleneimine, polyvinylpyridine, and polyallylamine). The pH range of micellization in which both components are ionized was determined for each polyamine. The resulting PIC micelles were characterized using dynamic light scattering and small-angle X-ray scattering experiments (SAXS). The PIC micelles presented a core-corona nanostructure with variable polymer density contrasts between the core and the corona, as revealed by the analysis of the SAXS curves. It was shown that PIC micelle cores constituted by polyacrylate chains and polyamines were more or less dense depending on the nature of the polyamine. It was also determined that the density of the cores of the PIC micelles depended strongly on the nature of the polyamine. These homogeneous cores were surrounded by a large hairy corona of hydrated polyethylene oxide block chains. Auramine O (AO) was successfully entrapped in the PIC micelles, and its fluorescence properties were used to get more insight on the core properties. Fluorescence data confirmed that the cores of such micelles are quite compact and that their microviscosity depended on the nature of the polyamine. The results obtained on these core-shell micelles allow contemplating a wide range of applications in which the AO probe would be replaced by various cationic drugs or other similarly charged species to form drug nanocarriers or new functional nanodevices.

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“…These materials were then subjected to CuAAC crosslinking in one pot with a PEG dialkyne and N,N-dimethyl propargylamine to yield amphiphilic materials with grafted amine functionalities ( Scheme 25,136). [136] The authors demonstrated the pH-dependent swelling of the final materials as well as the pH-dependent release of a model dye cargo. This work provides another example of the tailoring of physical properties of networks such as hydrogels by the use of alternately functionalized click components (alkynylamines in this case) in the CuAAC step.…”

Section: Scheme 24mentioning

confidence: 99%

Construction of Linear Polymers, Dendrimers, Networks, and Other Polymeric Architectures by Copper‐Catalyzed Azide‐Alkyne Cycloaddition “Click” Chemistry

Johnson

Finn

Koberstein

et al. 2008

Macromol. Rapid Commun.

307

159

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The enrichment of materials synthesis with the diverse chemical building blocks and functional groups of small molecule organic chemistry has been greatly accelerated in recent years by the introduction of the copper‐catalyzed azide‐alkyne cycloaddition (CuAAC). The efficiency and modular nature of this unique reaction enables materials chemists to prepare novel functional materials of unprecedented complexity. This review summarizes the application of CuAAC to the field of materials construction, defined here as the preparation of materials with architectural integrity dependent upon the triazole linkage. Recent examples, including linear polymers, dendrimers, polymer networks, polymeric nanoparticles, and other polymeric architectures, are described.magnified image

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pH-responsive biodegradable amphiphilic networks

Cited by 34 publications

References 20 publications

Synthesis and Characterization of Inulin-Based Responsive Polyurethanes for Breast Cancer Applications

Synthesis and Characterization of Inulin-Based Responsive Polyurethanes for Breast Cancer Applications

Physicochemical properties of pH-controlled polyion complex (PIC) micelles of poly(acrylic acid)-based double hydrophilic block copolymers and various polyamines

Construction of Linear Polymers, Dendrimers, Networks, and Other Polymeric Architectures by Copper‐Catalyzed Azide‐Alkyne Cycloaddition “Click” Chemistry

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