pH-responsive and self-targeting assembly from hyaluronic acid-based conjugate toward all-in-one chemo-photodynamic therapy

Wu, Jilian; Hu, Xu; Liu, Ruiling; Zhang, Jing; Song, Aixin; Luan, Yuxia

doi:10.1016/j.jcis.2019.03.087

Cited by 36 publications

(21 citation statements)

References 48 publications

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“…Furthermore, the gas-shearing fabrication method overcomes the restriction of traditional microfluidic technologies which mostly make use of cytotoxic materials such as organic solvents, surfactants, and cross-linkers. As synergistic therapeutic methods are currently strongly explored for the treatment of various diseases, − the release concept and materials described in this study may provide an attractive approach for further exploring combined laser-triggered drug therapies and phototherapies, as schematically illustrated in Scheme .…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

Triggered Release from Cellulose Microparticles Inspired by Wood Degradation by Fungi

Zhang

Chen

et al. 2020

ACS Sustainable Chem. Eng.

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Triggered compound release has attracted considerable attention in recent years. However, the concepts and carriers reported for triggered release are often complex while non-approved ingredients are mostly used to make the carriers. In this study, a bioinspired reactive oxygen species (ROS)-mediated delivery system, triggered by light, is introduced. We took inspiration from the well-known ROS mediated degradation of wood (cellulose) by brown-rot fungi and designed microparticles which consist of a core of cellulose nanocrystals, loaded with a drug, surrounded by a light sensitive shell. Incorporating indocyanine green, an FDA-approved photosensitizer, in the shell of the microparticles generates ROS upon NIR laser irradiation which degrade the cellulose nanocrystals in the microparticles. It was revealed that doxorubicin, encapsulated in the cellulose core and used as a model compound in our study, becomes specifically released upon NIR irradiation of the microparticles. Attractive as well is that the microparticles are prepared by a simple one-step gas-shearing process and fully consist of compounds generally regarded as safe (GRAS).

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Section: Conclusion and Prospectsmentioning

confidence: 99%

Triggered Release from Cellulose Microparticles Inspired by Wood Degradation by Fungi

Zhang

Chen

et al. 2020

ACS Sustainable Chem. Eng.

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“…4−10 Hyaluronic acid (HA), an anionic polysaccharide, exhibits good biocompatibility and biodegradability and high affinity to cluster determinant 44 (CD44), which is a transmembrane glycoprotein that is overexpressed in various cancer cells. 11−14 Consequently, HA-based or HA-coated nanocarriers have been exploited in tumor chemotherapy, 15,16 photodynamic therapy, 17,18 and photothermal therapy 19 to achieve efficient antitumor effects.…”

Section: ■ Introductionmentioning

confidence: 99%

High-Order Assembly toward Polysaccharide-Based Complex Coacervate Nanodroplets Capable of Targeting Cancer Cells

Liu

Zhang

et al. 2020

Langmuir

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High-order assembly plays a significant role in the formation of living organisms containing a large number of biomacromolecules and, thus, enlightens the construction of nanomaterials that can load macromolecular payloads at a high efficiency. Herein, by choosing anionic hyaluronic acid (HA) as a model payload, we demonstrated how the electrostatic-interaction-induced high-order assembly can be used to load efficiently biomacromolecules into complex coacervate nanodroplets. The resultant assemblies were primarily composed of HA and cationic chitosan oligosaccharide/dextran (COS/Dex) nanogels and had a controllable structure while also exhibiting biological functionality. HA in the assemblies is capable of targeting CD44-overexpressed tumor cells through CD44-mediated endocytic pathways, which are elucidated herein. Therefore, this study provides a reliable approach for the efficient loading of macromolecular payloads into complex coacervate nanodroplets via electrostatic-attraction-induced high-order assembly.

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“…Figure 2(C) showed the FT-IR spectra of raw HCPT, raw Ce6, raw Chol-PEG 2000 , physical mixture of HCPT/Ce6/Chol-PEG 2000 , and HCPT/Ce6 NPs. The characteristic peaks at 1723, 1654, 1595 and 1503 cm À1 in the spectrum of raw HCPT were assigned to the C¼O stretching vibration, acylamino group, aromatic frame, and aromatic ring, respectively (Jing et al, 2020), while the spectrum bands of raw Ce6 focused on 2923 and 2853 cm À1 (asymmetric and symmetric C-H stretching vibrations), 1715 cm À1 (carbonyl stretching C¼O vibration), 1601 cm À1 (C¼C stretching vibration), together with 1510 cm À1 and 1448 cm À1 (aromatic frame) (Wu et al, 2019). Besides, the intensive and broad peak at 2890 and 1113 cm À1 in the spectrum of raw Chol-PEG 2000 mainly associated to the C-H stretching vibrations and C-O stretching vibrations, respectively (Xu et al, 2019b).…”

Section: Ft-ir Spectroscopymentioning

confidence: 99%

Amphiphilic block polymer-based self-assembly of high payload nanoparticles for efficient combinatorial chemo-photodynamic therapy

Zhao

Guan

et al. 2020

Drug Delivery

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pH-responsive and self-targeting assembly from hyaluronic acid-based conjugate toward all-in-one chemo-photodynamic therapy

Cited by 36 publications

References 48 publications

Triggered Release from Cellulose Microparticles Inspired by Wood Degradation by Fungi

Triggered Release from Cellulose Microparticles Inspired by Wood Degradation by Fungi

High-Order Assembly toward Polysaccharide-Based Complex Coacervate Nanodroplets Capable of Targeting Cancer Cells

Amphiphilic block polymer-based self-assembly of high payload nanoparticles for efficient combinatorial chemo-photodynamic therapy

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