Amphiphilic block polymer-based self-assembly of high payload nanoparticles for efficient combinatorial chemo-photodynamic therapy

Ma, Qisan; Zhao, Yanna; Guan, Qingran; Zhao, Yuping; Zhang, Huaizhen; Ding, Zhuang; Wang, Qingpeng; Wu, Yushu; Liu, Min; Han, Jun

doi:10.1080/10717544.2020.1850921

Cited by 15 publications

(10 citation statements)

References 49 publications

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“…51 , 52 Studies have shown that HCPT and photosensitizer loaded PEG NPs showed excellent anticancer efficiency under laser irradiation. 53 , 54 In addition to light triggering, the development of photosensitizers activated by specific triggers such as enzyme-activated has received much attention. 55 , 56 Lu et al synthesized a cathepsin B-activated photosensitizer, further PEGylated and modified with tumor cell-targeting peptide cRGD and used as a nanocarrier to load HCPT.…”

Section: Organic Npsmentioning

confidence: 99%

Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin

Chen¹,

Wang²,

Wang³

et al. 2022

IJN

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10-Hydroxycamptothecin (HCPT) is a natural plant alkaloid from Camptotheca that shows potent antitumor activity by targeting intracellular topoisomerase I. However, factors such as instability of the lactone ring and insolubility in water have limited the clinical application of this drug. In recent years, unprecedented advances in biomedical nanotechnology have facilitated the development of nano drug delivery systems. It has been found that nanomedicine can significantly improve the stability and water solubility of HCPT. NanoMedicines with different diagnostic and therapeutic functions have been developed to significantly improve the anticancer effect of HCPT. In this paper, we collected reports on HCPT nanomedicines against tumors in the past decade. Based on current research advances, we dissected the current status and limitations of HCPT nanomedicines development and looked forward to future research directions.

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Section: Organic Npsmentioning

confidence: 99%

Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin

Chen¹,

Wang²,

Wang³

et al. 2022

IJN

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“…In this regard, it has recently been demonstrated that different chemophotodynamic treatments can induce a synergistic cytotoxic effect on HeLa cells [ 41 , 44 , 45 , 46 , 47 , 48 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

Dual-Functionalized Nanoliposomes Achieve a Synergistic Chemo-Phototherapeutic Effect

Lázaro-Carrillo

Rodríguez-Amigo

Mora

et al. 2022

IJMS

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The enhancement of photodynamic therapy (PDT) effectiveness by combining it with other treatment modalities and improved drug delivery has become an interesting field in cancer research. We have prepared and characterized nanoliposomes containing the chemotherapeutic drug irinotecan (CPT11lip), the photodynamic agent protoporphyrin IX (PpIXlip), or their combination (CPT11-PpIXlip). The effects of individual and bimodal (chemo-phototherapeutic) treatments on HeLa cells have been studied by a combination of biological and photophysical studies. Bimodal treatments show synergistic cytotoxic effects on HeLa cells at relatively low doses of PpIX/PDT and CPT11. Mechanistic cell inactivation studies revealed mitotic catastrophe, apoptosis, and senescence contributions. The enhanced anticancer activity is due to a sustained generation of reactive oxygen species, which increases the number of double-strand DNA breaks. Bimodal chemo-phototherapeutic liposomes may have a very promising future in oncological therapy, potentially allowing a reduction in the CPT11 concentration required to achieve a therapeutic effect and overcoming resistance to individual cancer treatments.

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“…[ 12‐20 ] However, simple bolus administration of chemotherapeutics and photodynamic therapeutics cannot achieve sustained synergistic therapeutic effects due to differential pharmacokinetics, biodistribution, and metabolism profiles of the drugs. [ 21 ] Thus, various types of nanoscale drug delivery systems (NDDSs), such as liposomes, [ 22‐23 ] polymeric micelles, [ 24‐30 ] mesoporous silica nanoparticles, [ 31 ] and others, [ 32‐38 ] have been developed for the co‐delivery of chemotherapeutics and photodynamic therapeutics. NDDSs are expected to overcome drug resistance by increased drug solubility, prolonged circulation time, programmed drug release, and sometimes improved cellular uptake.…”

Section: Background and Originality Contentmentioning

confidence: 99%

Co‐delivery of Cisplatin and Chlorin e6 by Poly(phosphotyrosine) for Synergistic Chemotherapy and Photodynamic Therapy

et al. 2022

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Comprehensive Summary Nanoscale drug delivery systems (NDDSs) have emerged as promising carriers for combinational therapy by co‐delivery of multiple drugs and modalities. However, most co‐delivery systems require the use of complicated materials and formulations. Herein, we report the single use of a polymeric material, namely mPEG‐block‐poly(phosphotyrosine) (mPEG‐b‐PpY), as a multi‐functional carrier for the facile fabrication of NDDS Pt/Ce6@mPEG‐b‐PpY (PtCeNP) for the co‐delivery of cisplatin and photosensitizer chlorin e6 (Ce6) via phosphato‐platinum coordination and π‐π stacking, respectively. PtCeNP improves the solubility, cellular uptake, and bioavailability of both parental drugs, and showed strong synergistic antitumor efficacy both in vitro and in vivo through combined chemo‐photodynamic therapy. Our results indicate that PpY is a biocompatible, multifunctional, and promising carrier material suitable for a variety of drugs and may simplify the design for co‐delivery systems.

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Amphiphilic block polymer-based self-assembly of high payload nanoparticles for efficient combinatorial chemo-photodynamic therapy

Abstract: (2020) Amphiphilic block polymerbased self-assembly of high payload nanoparticles for efficient combinatorial chemo-photodynamic therapy,

Cited by 15 publications

References 49 publications

Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin

Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin

Dual-Functionalized Nanoliposomes Achieve a Synergistic Chemo-Phototherapeutic Effect

Co‐delivery of Cisplatin and Chlorin e6 by Poly(phosphotyrosine) for Synergistic Chemotherapy and Photodynamic Therapy

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