2022
DOI: 10.1016/j.bioadv.2022.213015
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pH/redox-responsive core cross-linked based prodrug micelle for enhancing micellar stability and controlling delivery of chemo drugs: An effective combination drug delivery platform for cancer therapy

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Cited by 10 publications
(2 citation statements)
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“…Especially, hybrid-polymers consisting of PAsp n and poly(ethylene glycol) attracted a lot of attention as carrier for anti-cancer drugs. [106][107][108][109] These two types of peptides show good solubility in organic solvents, the possibility to convert them into water-soluble polypeptides by removal of the side chain protection groups [110] and a dynamic behavior in their secondary structure formation. Although these two types of poly(amino acids) usually adopt the right-handed 𝛼-helix (𝛼 r )-helix, the final conformation strongly depends on chemical and physical conditions introduced to the system such as molecular weight, the used solvent, end group, temperature or substitution of the side chain benzyl-group.…”
Section: Secondary Structure Of the Oligo(amino Acids) P Bn Glu N ; P...mentioning
confidence: 99%
“…Especially, hybrid-polymers consisting of PAsp n and poly(ethylene glycol) attracted a lot of attention as carrier for anti-cancer drugs. [106][107][108][109] These two types of peptides show good solubility in organic solvents, the possibility to convert them into water-soluble polypeptides by removal of the side chain protection groups [110] and a dynamic behavior in their secondary structure formation. Although these two types of poly(amino acids) usually adopt the right-handed 𝛼-helix (𝛼 r )-helix, the final conformation strongly depends on chemical and physical conditions introduced to the system such as molecular weight, the used solvent, end group, temperature or substitution of the side chain benzyl-group.…”
Section: Secondary Structure Of the Oligo(amino Acids) P Bn Glu N ; P...mentioning
confidence: 99%
“…Compared with free Dox, the three Dox-loaded micelles possessed steady and sustained release behavior, and less than 25% of Dox was released from micelles with 96 h in the pH 7.4 condition, which proved that the three Dox-loaded micelles were considerably stable and could prevent drug leakage before reaching the tumor site. Once Dox-loaded micelles were exposed to the pH 5.5 condition, the amount of Dox cumulative release was gradually raised, and approximately 27.51%, 29.85% and 33.10% Dox released from the LC-Cys-OA, LC-Cys-DA and LC-Cys-CA micelles, which might be due to the improved solubility of Dox depending on protonation of the amine groups [26]. After adding 10 mM GSH, which mimics the tumor microenvironment, the release percentage of Dox was promoted significantly, and nearly 46.80%, 54.35% and 73.97% encapsulated Dox was released from the LC-Cys-OA, LC-Cys-DA and LC-Cys-CA micelles after 96 h, which was 2 times higher than that in the pH 5.5 condition without GSH.…”
Section: In Vitro Stimuli-responsive Releasementioning
confidence: 99%