pH/redox-responsive core cross-linked based prodrug micelle for enhancing micellar stability and controlling delivery of chemo drugs: An effective combination drug delivery platform for cancer therapy

Gebrie, Hailemichael Tegenu; Addisu, Kefyalew Dagnew; Darge, Haile Fentahun; Birhan, Yihenew Simegniew; Thankachan, Darieo; Tsai, Hsieh‐Chih; Wu, Szu-Yuan

doi:10.1016/j.bioadv.2022.213015

Cited by 10 publications

(2 citation statements)

References 86 publications

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“…Especially, hybrid-polymers consisting of PAsp n and poly(ethylene glycol) attracted a lot of attention as carrier for anti-cancer drugs. [106][107][108][109] These two types of peptides show good solubility in organic solvents, the possibility to convert them into water-soluble polypeptides by removal of the side chain protection groups [110] and a dynamic behavior in their secondary structure formation. Although these two types of poly(amino acids) usually adopt the right-handed 𝛼-helix (𝛼 r )-helix, the final conformation strongly depends on chemical and physical conditions introduced to the system such as molecular weight, the used solvent, end group, temperature or substitution of the side chain benzyl-group.…”

Section: Secondary Structure Of the Oligo(amino Acids) P Bn Glu N ; P...mentioning

confidence: 99%

Secondary Structures in Synthetic Poly(Amino Acids): Homo‐ and Copolymers of Poly(Aib), Poly(Glu), and Poly(Asp)

Rohmer¹,

Freudenberg²,

Binder³

2023

Macromolecular Bioscience

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The secondary structure of poly(amino acids) is an excellent tool for controlling and understanding the functionality and properties of proteins. In this perspective article the secondary structures of the homopolymers of oligo‐ and poly‐glutamic acid (Glu), aspartic acid (Asp), and α‐aminoisobutyric acid (Aib) are discussed. Information on external and internal factors, such as the nature of side groups, interactions with solvents and interactions between chains is reviewed. A special focus is directed on the folding in hybrid‐polymers consisting of oligo(amino acids) and synthetic polymers. Being part of the SFB TRR 102 “Polymers under multiple constraints: restricted and controlled molecular order and mobility” this overview is embedded into the cross section of protein fibrillation and supramolecular polymers. As polymer‐ and amino acid folding is an important step for the utilization and design of future biomolecules these principles guide to a deeper understanding of amyloid fibrillation.

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Section: Secondary Structure Of the Oligo(amino Acids) P Bn Glu N ; P...mentioning

confidence: 99%

Secondary Structures in Synthetic Poly(Amino Acids): Homo‐ and Copolymers of Poly(Aib), Poly(Glu), and Poly(Asp)

Rohmer¹,

Freudenberg²,

Binder³

2023

Macromolecular Bioscience

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“…Compared with free Dox, the three Dox-loaded micelles possessed steady and sustained release behavior, and less than 25% of Dox was released from micelles with 96 h in the pH 7.4 condition, which proved that the three Dox-loaded micelles were considerably stable and could prevent drug leakage before reaching the tumor site. Once Dox-loaded micelles were exposed to the pH 5.5 condition, the amount of Dox cumulative release was gradually raised, and approximately 27.51%, 29.85% and 33.10% Dox released from the LC-Cys-OA, LC-Cys-DA and LC-Cys-CA micelles, which might be due to the improved solubility of Dox depending on protonation of the amine groups [26]. After adding 10 mM GSH, which mimics the tumor microenvironment, the release percentage of Dox was promoted significantly, and nearly 46.80%, 54.35% and 73.97% encapsulated Dox was released from the LC-Cys-OA, LC-Cys-DA and LC-Cys-CA micelles after 96 h, which was 2 times higher than that in the pH 5.5 condition without GSH.…”

Section: In Vitro Stimuli-responsive Releasementioning

confidence: 99%

Effect of Hydrophobic Chain Length in Amphiphilic Chitosan Conjugates on Intracellular Drug Delivery and Smart Drug Release of Redox-Responsive Micelle

Yuan,

Tan,

et al. 2023

Marine Drugs

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Three redox-sensitive nanocarriers were rationally designed based on amphiphilic low molecular weight chitosan-cystamine-octylamine/dodecylamin/cetylamine (LC-Cys-OA, LC-Cys-DA, LC-Cys-CA) conjugates containing disulfide linkage for maximizing therapeutic effect by regulating hydrophobic interaction. The resultant spherical micelles had the characteristics of low CMC, suitable size, excellent biosafety and desired stability. The drug-loaded micelles were fabricated by embedding doxorubicin (Dox) into the hydrophobic cores. The effect of hydrophobic chain lengths of amphiphilic conjugates on encapsulation capacity, redox sensitivity, trigger-release behavior, cellular uptake efficacy, antitumor effect and antimigratory activity of Dox-loaded micelles was systematically investigated. Studies found that Dox-loaded LC-Cys-CA micelle had superior loading capacity and enhanced redox sensitivity compared with the other two micelles. Release assay indicated that the three Dox-loaded micelles maintained sufficiently stability in normal blood circulation but rapidly disintegrated in tumor cells. More importantly, the LC-Cys-CA micelle with a longer hydrophobic chain length exhibited a higher accumulative Dox release percentage than the other two micelles. Additionally, an increase in hydrophobic chain lengths of amphiphilic conjugates improved cellular uptake efficiency, antitumor effect and antimigration activity of Dox-loaded micelles, which could be explained by enhanced loading ability and redox sensitivity. Our research was expected to provide a viable platform for achieving a desired therapeutic efficacy via the alteration of hydrophobic interaction.

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Stimuli‐responsive silk fibroin for on‐demand drug delivery

et al. 2023

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Stimuli‐responsive “smart” hydrogel biomaterials have attracted great attention in the biomedical field, especially in designing novel on‐demand drug delivery systems. As a handful natural biomaterial approved by US Food and Drug Administration, silk fibroin (SF) has unique high temperature resistance as well as tunable structural composition. These properties make it one of the most ideal candidates for on‐demand drug delivery. Meanwhile, recent advances in polymer modification and nanomaterials have fostered the development of various stimuli‐responsive delivery systems. Here, we first review the recent advance in designing responsive SF‐based delivery systems in different stimulus sources. These systems are able to release mediators in a desired manner in response to specific stimuli in active or passive manners. We then describe applications of these specially designed responsive delivery systems in wound healing, tumor therapy, as well as immunomodulation. We also discuss the future challenges and prospects of stimuli‐responsive SF‐based delivery systems.

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pH/redox-responsive core cross-linked based prodrug micelle for enhancing micellar stability and controlling delivery of chemo drugs: An effective combination drug delivery platform for cancer therapy

Cited by 10 publications

References 86 publications

Secondary Structures in Synthetic Poly(Amino Acids): Homo‐ and Copolymers of Poly(Aib), Poly(Glu), and Poly(Asp)

Secondary Structures in Synthetic Poly(Amino Acids): Homo‐ and Copolymers of Poly(Aib), Poly(Glu), and Poly(Asp)

Effect of Hydrophobic Chain Length in Amphiphilic Chitosan Conjugates on Intracellular Drug Delivery and Smart Drug Release of Redox-Responsive Micelle

Stimuli‐responsive silk fibroin for on‐demand drug delivery

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