pH/near-infrared light dual activated Ce6-doped silicon nanoparticles with tumor chemo-photodynamic synergistic therapy for improving efficiency of monotherapy

Ma, Tonghao; Zhang, Qi; Xuan, Qize; Zhuang, Jiafeng; Zhang, Wei; Li, Hui; Chen, Chao; Wang, Ping

doi:10.1016/j.cej.2021.130536

Cited by 11 publications

(5 citation statements)

References 50 publications

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“…To evaluate cell apoptosis quantitatively and accurately, K7M2wt-Luc cells cultured with the electrospun nanofibers for 24 and 48 h were double-stained with annexin V FITC/PI and analyzed by flow cytometer. As shown in Figure e and SI, Figure S8), almost no cells underwent apoptosis in the blank and PCL-treated groups, while cells apoptosis rates at a timepoint of 48 h in the electrospun DOX@BSA/PCL-, PCL/MnO 2 , and DOX@BSA/PCL/MnO 2 -treated groups were 11.59% ± 0.57%, 15.5% ± 2.41%, and 36.59% ± 0.63%, respectively, indicating that CT drugs of DOX and CDT agents of MnO 2 had a synergistic killing effect on K7M2wt-Luc cancer cells . Collectively, application of the electrospun DOX@BSA/PCL/MnO 2 nanofiber in treatment of spinal tumors was of great significance, as revealed from the in vitro antitumor activity results.…”

Section: Resultsmentioning

confidence: 99%

Dual-Modal Imaging and Synergistic Spinal Tumor Therapy Enabled by Hierarchical-Structured Nanofibers with Cascade Release and Postoperative Anti-adhesion

Qian

et al. 2022

ACS Nano

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Most treatments for spinal cancer are accompanied by serious side effects including subsequent tumor recurrence, spinal cord compression, and tissue adhesion, thus a highly effective treatment is crucial for preserving spinal and neurological functionalities. Herein, trilayered electrospun doxorubicin@bovine serum albumin/poly(ε-caprolactone)/manganese dioxide (DOX@BSA/PCL/MnO2) nanofibers with excellent antiadhesion ability, dual glutathione/hydrogen peroxide (GSH/H2O2) responsiveness, and cascade release of Mn2+/DOX was fabricated for realizing an efficient spinal tumor therapy. In detail, Fenton-like reactions between MnO2 in the fibers outermost layer and intra-/extracellular glutathione within tumors promoted the first-order release of Mn2+. Then, sustained release of DOX from the fibers’ core layer occurred along with the infiltration of degradation fluid. Such release behavior avoided toxic side effects of drugs, regulated inflammatory tumor microenvironment, amplified tumor elimination efficiency through synergistic chemo-/chemodynamic therapies, and inhibited recurrence of spinal tumors. More interestingly, magnetic resonance and photoacoustic dual-modal imaging enabled visualizations of tumor therapy and material degradation in vivo, achieving rapid pathological analysis and diagnosis. On the whole, such versatile hierarchical-structured nanofibers provided a reference for rapid and potent theranostic of spinal cancer in future clinical translations.

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Section: Resultsmentioning

confidence: 99%

Dual-Modal Imaging and Synergistic Spinal Tumor Therapy Enabled by Hierarchical-Structured Nanofibers with Cascade Release and Postoperative Anti-adhesion

Qian

et al. 2022

ACS Nano

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“…The peaks at 2.2° (s-MS) and 2.1° (r-MS) are related to the two-dimensional hexagonal symmetry ( P 6 mm ), while the other peaks are related to the hexagonal structure of the MS . A decrease in diffraction intensities is observed in the XRD patterns for both s-MS-COOH and r-MS-COOH due to the reduction in pore sizes after functionalization . The interlayer spacings d (100) for both materials (4.01 nm for s-MS-COOH and 4.21 nm for r-MS-COOH) are in accordance with the TEM results …”

Section: Resultsmentioning

confidence: 99%

Responsive Supramolecular Devices Assembled from Pillar[5]arene Nanogate and Mesoporous Silica for Cargo Release

Silva

Costa

Fernandes

et al. 2022

ACS Appl. Nano Mater.

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In this work, cationic switchable pillar[5]arene nanogates that bear an imidazolium scaffold (MIP5+) were constructed, and these nanogates were used to electrostatically interact with negatively charged spherical mesoporous silica nanoparticles (96.0 ± 1.0 nm) and rod-shaped silica particles (391.0 ± 0.2 nm in length and 219 in width), which are both functionalized with carboxypropyl groups. The nanochannels of silica-based materials were used as containers to store the anticancer drug doxorubicin (DXR) trapped by the nanogate. Under physiological conditions (pH = 7.4), DXR molecules were firmly trapped in the nanochannels of the spherical and rod-shaped containers without any premature release, demonstrating that the nanogate was efficient in sealing the nanopores. Under acidic conditions (pH = 4.5), the carboxypropyl groups were protonated, and the electrostatic interactions between the containers and the nanogates were disrupted, releasing the drug. In vitro studies were performed to explore the differences between N-methylimidazolium-pillar[5]arene nanogate mounted on DXR-loaded spherical and rod-shaped containers and the resulting cytotoxicity effect against human breast adenocarcinoma cells and cellular uptake. A higher cytotoxicity effect and better cellular uptake were detected for the nanogate on DXR-loaded rod-shaped silica containers. Additionally, this device presents a lower uptake rate by nontumor cells than that of free DXR. Therefore, our findings indicate that the rod shape of mesoporous silica in nanogated devices is important due to the cytotoxicity effect and cellular uptake and should be further explored in drug delivery systems.

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“…As displayed in Figure S13 (Supporting Information), the red fluorescence of DOX in cells and the blue fluorescence in nuclei stained with 4', 6-diamidino-2-phenylindole (DAPI) displayed a superimposed effect, demonstrating the successful uptake of UCSSDH by cells for 6 h. Subsequently, Hela cells were incubated with different materials for 6 h. As shown in Figure 3a, the fluorescence of DOX was weakest in free-DOX, suggesting that the free small molecule was more difficult to be endocytosed than nanodelivery system. [43] Additionally, the fluorescence intensity of DOX in UCSSDH was stronger compared with UCSSD, which declared UCSSDH was taken up more by the cells and the splendid target impact of HA. In addition, the DOX fluorescence elevated visibly when the NIR laser irradiated for 5 min, confirming the light-responsiveness of DOX release.…”

Section: Targeting Cellular Uptake and Cytotoxicity Evaluationmentioning

confidence: 99%

Near‐Infrared Light Triggered Intelligent Nanoplatform for Synergistic Chemo‐Photodynamic Therapy of Tumor

Qian

Chen

Wang

et al. 2022

Advanced Optical Materials

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a more common treatment modality for cancer in clinical practice, which is attributed to the strong lethality of chemotherapeutic drugs. [4] However, single chemotherapeutic agents usually suffer from low therapeutic efficacy and serious side effects caused by inadequate accumulation at tumor site and poor selectivity. [5,6] Therefore, the investigation of various novel modalities with enormous potential has never ceased in tumor therapy. Photodynamic therapy (PDT), a minimally incursive therapy modality with the merits of spatial and temporal control, precise tumor specificity, and hypo-toxicity to normal tissues, has been vigorously developed in the past few years. [7][8][9] In general, the principle of type-II PDT is that photosensitizers generate cytotoxic reactive oxygen species (ROS) stimulated by light irradiation in the company of oxygen to prompt cell apoptosis. [10][11][12] Conventional photosensitizers are commonly excited by ultraviolet (UV) or visible light. Regrettably, UV-visible light has low biologic tissue penetration, which leads to poor PDT efficiency. [13] Near-infrared (NIR) light with deeper penetration is of great interest because of low absorption by biomolecules. [14,15] Coincidentally, rare earthbased upconversion nanoparticles (UCNPs) are outstanding choices for transferring NIR to UV-vis light, which achieves a balance between UV-vis light excitation of photosensitizers and deep biotissue penetration in PDT. In addition, UCNPs Chemo-photodynamic therapy nanodelivery systems provide a potential strategy to enhance anticancer effect. However, the treatment efficiency of stimuli-responsive nanotheranostics remains a challenge owing to off-target properties, poor tissue penetration, and slow drugs release. Herein, di-selenide-bridged mesoporous silica (Se-Se-mSiO 2 ) is introduced into a near-infrared (NIR) light triggered and tumor microenvironment (TME)-activated intelligent nanoplatform (UCNPs@mSiO 2 -Ce6@Se-Se-mSiO 2 (DOX)@HA (UCSSDH)) realizing burst drug release on demand. Typically, the UCSSDH actively targets cancer cells and accumulates in tumor site through hyaluronic acid (HA). Then, under the irradiation of 980 nm NIR light, the upconverted 650 nm emission light activates photosensitizer Ce6 to produce the singlet oxygen ( 1 O 2 ) for photodynamic therapy (PDT). More importantly, 1 O 2 further cleaves di-selenide bonds which are sensitive to reactive oxygen species (ROS), driving the rapid degradation of Se-Se-mSiO 2 accompanied by the burst release of doxorubicin (DOX). Consequently, UCSSDH achieves efficient chemophotodynamic therapy of tumors. Last but not least, the upconversion nanoparticles (UCNPs) perform upconversion luminescence (UCL) imaging to monitor the drugs delivery. Collectively, an intelligent drug delivery system integrating therapeutic, monitoring, and targeting is exploited for NIR light-triggered synergistic tumor therapy. This study broadens fresh vision into the development of controlled drug release and provides a momentous thought for potential clinic...

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pH/near-infrared light dual activated Ce6-doped silicon nanoparticles with tumor chemo-photodynamic synergistic therapy for improving efficiency of monotherapy

Cited by 11 publications

References 50 publications

Dual-Modal Imaging and Synergistic Spinal Tumor Therapy Enabled by Hierarchical-Structured Nanofibers with Cascade Release and Postoperative Anti-adhesion

Dual-Modal Imaging and Synergistic Spinal Tumor Therapy Enabled by Hierarchical-Structured Nanofibers with Cascade Release and Postoperative Anti-adhesion

Responsive Supramolecular Devices Assembled from Pillar[5]arene Nanogate and Mesoporous Silica for Cargo Release

Near‐Infrared Light Triggered Intelligent Nanoplatform for Synergistic Chemo‐Photodynamic Therapy of Tumor

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