pH-dependent swelling and antibiotic release from citric acid crosslinked poly(vinyl alcohol) (PVA)/nano silver hydrogels

Sabzi, Mohammad; Afshari, Mehdi; Babaahmadi, Masoud; Shafagh, Nima

doi:10.1016/j.colsurfb.2019.110757

Cited by 103 publications

(109 citation statements)

References 61 publications

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“…Our findings are in agreement with the previous work obtained from Preparation of polyurethane/poly vinyl alcohol hydrogel and its performance enhancement via composting with silver particles 66 . Those results are in accordance with the reported results during the study of pH‐sensitive and antibacterial drug delivery system based on polyvinylalcohol(PVA)/citricacid(CA)/Ag nanoparticles (NPs) is designed using a completely green, facile and one‐step route 67 . The water retention properties of the nano silver embedded PPO/PEO‐C hybrid composite hydrogels with 11.87 × 10 −4 concentrations of Ag NPs are explained in Supporting Information S2 and Figure S2.…”

Section: Resultssupporting

confidence: 93%

Polypropylene oxide/polyethylene oxide‐cellulose hybrid nanocomposite hydrogels as drug delivery vehicle

Prusty

Swain

2020

J of Applied Polymer Sci

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This article deals with the synthesis of hybrid nanocomposite hydrogels through the combination of cellulose (C), polypropylene oxide/poly ethylene oxide (PPO/PEO), and silver nanoparticles (AgNPs) by in situ polymerization technique for the in vitro release of ornidazole drugs. The structure of the resulted materials is identified using SEM, XRD, FTIR, XPS, and TGA spectroscopic techniques. The resulting structure, morphology, thermo responsive property, water retention, and swelling behavior of hydrogels are investigated. The rheological measurement is studied to establish the enhancement of the viscoelasticity and stiffness of hydrogels. The antibacterial activity of the biodegradable silver hybrid nanocomposite hydrogel is investigated by inhibition zone method against gram positive and negative bacteria. Maximum drug release of 96.4% is recorded at 7.4 pH in 5 h. The biocompatibility and cytotoxicity of the hybrid nanocomposite hydrogel are verified using mouse fibroblast cell line L-929 (ATCC CCL-1) cells for their possible use as controlled drug delivery vehicles. The nontoxic nature makes the materials more biocompatible and suitable to apply in the biological systems. Therefore, nontoxic and biocompatible natures of present materials with improved thermal and rheological properties support for their possible uses as drug delivery vehicles.

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Section: Resultssupporting

confidence: 93%

Polypropylene oxide/polyethylene oxide‐cellulose hybrid nanocomposite hydrogels as drug delivery vehicle

Prusty

Swain

2020

J of Applied Polymer Sci

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“…The citric acid (CA) with one hydroxyl and three carboxyl groups exists widely in citrus fruits and pineapples, and it is currently used as a preservative, food additive, and cleaning agent. 20 Being a polycarboxylic acid, CA can be used as a natural crosslinking agent in the thermal crosslinking process of PVA films, which may react with the hydroxyl groups of PVA chains at high temperature and produce intermolecular and intramolecular ester linkages among them. 21 In this paper, electrospun poly(vinyl alcohol) microfibre mats with high water stability and water absorption capacity were obtained through a heat-induced in situ cross-link process with citric acid.…”

mentioning

confidence: 99%

Fabrication, characterization, and antibacterial properties of citric acid crosslinked PVA electrospun microfibre mats for active food packaging

Dong

Feng

et al. 2021

Packag Technol Sci

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In this study, electrospun poly(vinyl alcohol) (PVA) microfibre mats incorporated with clove oil (CO) with high water-stability and water absorption ability were prepared through a heat-induced in situ cross-linkage with citric acid (CA). The effects of CA content on the electrospinning solution properties and physical properties of the crosslinked microfibre mats were investigated. The Fourier transform infrared spectroscopy showed that the esterification could occur between hydroxyl groups on the PVA and carboxyl groups on citric acid. The established strong interactions of citric acid and PVA after crosslinking improved the thermal stability, mechanical properties, contact angle, and water stability. The bacterial growth kinetics and the disk diffusion assay proved that the PVA/CA/CO microfibre mats had an obvious inhibitory effect on E. coli and S. aureus. The results showed the PVA/CA/CO microfibre mats would be a promising package material for food products.

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“…There are currently more reports on pH‐responsive nanogels for antibacterial delivery compared to other stimuli such as enzymes, temperature, and redox. These includes studies conducted by various research groups (Bashari, Hemmatinejad, & Pourjavadi, 2017; Chinga‐Carrasco & Syverud, 2014; Prusty & Swain, 2018; Reddy, Rao, Rao, Reddy, & Eswaramma, 2015; Sabzi, Afshari, Babaahmadi, & Shafagh, 2020; Simonson, Lawanprasert, Goralski, Keiler, & Medina, 2019; Ulker et al, 2017). Table 6 provides the detailed antibacterial outcomes and experimental conditions employed for all the pH‐responsive nanogel studies that have been reported thus far.…”

Section: Intrinsic Stimuli‐responsive Nanocarriers For Antibacterial mentioning

confidence: 99%

“…The results obtained showed that the nanogels were within the range of 10–100 nm and had porous structures to allow drug diffusion from the nanogel, which are both beneficial for antibacterial applications. While Simonson and Sabzi, alongside their respective colleagues (Sabzi et al, 2020; Simonson et al, 2019), used common antibiotics in their studies (vancomycin and ciprofloxacin, respectively), other groups of scientists used different antibacterial agents such as ornidazole (Prusty & Swain, 2018), 5‐flurocil (Reddy et al, 2015), and aroma (Bashari et al, 2017). This further revealed the antibacterial efficacy of antibacterial agents that are not commonly investigated.…”

Section: Intrinsic Stimuli‐responsive Nanocarriers For Antibacterial mentioning

confidence: 99%

“…The common antibacterial techniques that were used in these studies were MIC using a microplate reader (Simonson et al, 2019); the parallel streak method (Bashari et al, 2017); and the disk diffusion method (Reddy et al, 2015; Sabzi et al, 2020; Ulker et al, 2017). This implies that these techniques are still valid for testing the antibacterial efficacy of drug delivery systems, such as nanogels, as statistically significant results were reported.…”

Section: Intrinsic Stimuli‐responsive Nanocarriers For Antibacterial mentioning

confidence: 99%

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Intrinsic stimuli‐responsive nanocarriers for smart drug delivery of antibacterial agents—An in‐depth review of the last two decades

Devnarain

Osman

Fasiku

et al. 2020

WIREs Nanomed Nanobiotechnol

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Antibiotic resistance due to suboptimal targeting and inconsistent antibiotic release at bacterial infection sites has driven the formulation of stimuli‐responsive nanocarriers for antibacterial therapy. Unlike conventional nanocarriers, stimuli‐responsive nanocarriers have the ability to specifically enhance targeting and drug release profiles. There has been a significant escalation in the design and development of novel nanomaterials worldwide; in particular, intrinsic stimuli‐responsive antibiotic nanocarriers, due to their enhanced activity, improved targeted delivery, and superior potential for bacterial penetration and eradication. Herein, we provide an extensive and critical review of pH‐, enzyme‐, redox‐, and ionic microenvironment‐responsive nanocarriers that have been reported in literature to date, with an emphasis on the mechanisms of drug release, the nanomaterials used, the nanosystems constructed and the antibacterial efficacy of the nanocarriers. The review also highlights further avenues of research for optimizing their potential and commercialization. This review confirms the potential of intrinsic stimuli‐responsive nanocarriers for enhanced drug delivery and antibacterial killing. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

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pH-dependent swelling and antibiotic release from citric acid crosslinked poly(vinyl alcohol) (PVA)/nano silver hydrogels

Cited by 103 publications

References 61 publications

Polypropylene oxide/polyethylene oxide‐cellulose hybrid nanocomposite hydrogels as drug delivery vehicle

Polypropylene oxide/polyethylene oxide‐cellulose hybrid nanocomposite hydrogels as drug delivery vehicle

Fabrication, characterization, and antibacterial properties of citric acid crosslinked PVA electrospun microfibre mats for active food packaging

Intrinsic stimuli‐responsive nanocarriers for smart drug delivery of antibacterial agents—An in‐depth review of the last two decades

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