2019
DOI: 10.3390/microorganisms7120623
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PgRsp Is a Novel Redox-Sensing Transcription Regulator Essential for Porphyromonas gingivalis Virulence

Abstract: Porphyromonas gingivalis is one of the etiological agents of chronic periodontitis. Both heme and oxidative stress impact expression of genes responsible for its survival and virulence. Previously we showed that P. gingivalis ferric uptake regulator homolog affects expression of a gene encoding a putative Crp/Fnr superfamily member, termed P. gingivalis redox-sensing protein (PgRsp). Although PgRsp binds heme and shows the highest similarity to proteins assigned to the CooA family, it could be a member of a no… Show more

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Cited by 5 publications
(7 citation statements)
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“…PgRsp is a member of the Crp/Fnr superfamily transcription regulators responsible for haem-binding and redox state sensing through haem-catalysed oxidation [ 76 , 77 ]. In support of these roles, pgrsp mutants showed a reduced uptake of haem mediated by HmuY in biofilm-forming conditions [ 76 , 78 ]. Further, PgRsp has been implicated in modulation of bacterial virulence.…”
Section: Transcriptional Mechanisms Of Pathogenicity In Periodontal B...mentioning
confidence: 99%
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“…PgRsp is a member of the Crp/Fnr superfamily transcription regulators responsible for haem-binding and redox state sensing through haem-catalysed oxidation [ 76 , 77 ]. In support of these roles, pgrsp mutants showed a reduced uptake of haem mediated by HmuY in biofilm-forming conditions [ 76 , 78 ]. Further, PgRsp has been implicated in modulation of bacterial virulence.…”
Section: Transcriptional Mechanisms Of Pathogenicity In Periodontal B...mentioning
confidence: 99%
“…Further, PgRsp has been implicated in modulation of bacterial virulence. For example, upregulation of the expression of kgp and downregulation of the expression of rgpB and rgpA were observed when comparing the pgrsp knock-out mutant to the wild-type [ 76 ]. Inactivation of the PgRsp-encoding gene in P. gingivalis resulted in increased coaggregation with both Prevotella intermedia and T. forsythia whilst coaggregation with Streptococcus gordonii was not affected by mutagenesis [ 76 ].…”
Section: Transcriptional Mechanisms Of Pathogenicity In Periodontal B...mentioning
confidence: 99%
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“…The gene PG_RS02100 expressed only during logarithmic growth, and the gene PG1660 in P. gingivalis participate in the oxidative stress response (Phillips et al, 2018;Dou et al, 2018). More recently, a novel redox-sensing transcription regulator was identified as P. gingivalis redoxsensing protein (PgRsp) (Smiga and Olczak, 2019). When challenged by oxidative stress, PgRsp can regulate gene expression alongside or cooperate with other transcription factors to resist oxidative stress (Smiga and Olczak, 2019).…”
Section: Resistance To Ros-mediated Killingmentioning
confidence: 99%
“…More recently, a novel redox-sensing transcription regulator was identified as P. gingivalis redoxsensing protein (PgRsp) (Smiga and Olczak, 2019). When challenged by oxidative stress, PgRsp can regulate gene expression alongside or cooperate with other transcription factors to resist oxidative stress (Smiga and Olczak, 2019). Although several regulatory proteins have been identified in the oxidative stress resistance pathway, the regulatory network is not clear.…”
Section: Resistance To Ros-mediated Killingmentioning
confidence: 99%