PGC-1α promotes colorectal carcinoma metastasis through regulating ABCA1 transcription

Chen, Wei; Zhang, Qiushuang; Dai, Xiaoshuo; Chen, Xinhuan; Zhang, Chengjuan; Bai, Ru; Chen, Yihuan; Zhang, Kai; Duan, Xiaoxuan; Qiao, Yan; Zhao, Jimin; Tian, Fang; Liu, Kangdong; Dong, Ziming; Lü, Jing

doi:10.1038/s41388-023-02762-y

Cited by 2 publications

(2 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mechanistically, PGC-1α interacts with transcription factor YY1, further stimulating ATP-binding cassette transporter 1 (ABCA1) transcription and ABCA1-mediated cholesterol efflux, which aggravates epithelial-mesenchymal transition (EMT), ultimately facilitating CRC metastasis. 282 Another downstream pathway of PGC-1α in CRC is AKT/GSK-3β/β-catenin. 283,284 PGC-1α knockdown downregulates the expression of p-AKT, p-GSK-3β, β-catenin, N-cadherin and mitigates cell proliferation, migration, and invasion, while the opposite effects are observed in PGC-1α overexpressing cells.…”

Section: The Role Of Pgc-1s In Pathophysiological Processes and Disea...mentioning

confidence: 99%

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases

Qian,

Zhu,

Deng

et al. 2024

Sig Transduct Target Ther

View full text Add to dashboard Cite

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s), consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related coactivator (PRC), was discovered more than a quarter-century ago. PGC-1s are essential coordinators of many vital cellular events, including mitochondrial functions, oxidative stress, endoplasmic reticulum homeostasis, and inflammation. Accumulating evidence has shown that PGC-1s are implicated in many diseases, such as cancers, cardiac diseases and cardiovascular diseases, neurological disorders, kidney diseases, motor system diseases, and metabolic disorders. Examining the upstream modulators and co-activated partners of PGC-1s and identifying critical biological events modulated by downstream effectors of PGC-1s contribute to the presentation of the elaborate network of PGC-1s. Furthermore, discussing the correlation between PGC-1s and diseases as well as summarizing the therapy targeting PGC-1s helps make individualized and precise intervention methods. In this review, we summarize basic knowledge regarding the PGC-1s family as well as the molecular regulatory network, discuss the physio-pathological roles of PGC-1s in human diseases, review the application of PGC-1s, including the diagnostic and prognostic value of PGC-1s and several therapies in pre-clinical studies, and suggest several directions for future investigations. This review presents the immense potential of targeting PGC-1s in the treatment of diseases and hopefully facilitates the promotion of PGC-1s as new therapeutic targets.

show abstract

Section: The Role Of Pgc-1s In Pathophysiological Processes and Disea...mentioning

confidence: 99%

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases

Qian,

Zhu,

Deng

et al. 2024

Sig Transduct Target Ther

View full text Add to dashboard Cite

show abstract

“…Besides, peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), being a regulator of mitochondrial function, can promote ABCA1 expression to promote CRC metastasis through EMT. Chen et al found that the natural compound Isoliquiritigenin (ISL), as an inhibitor of PGC-1α, targeted ABCA1 and reduced CRC metastasis by inhibiting EMT (W. Chen W et al, 2023 ). All in all, the components of TCM can effectively regulate multiple factors and steps of CRC to inhibiting migration, invasion and adhesion.…”

Section: Application Of Components In Crcmentioning

confidence: 99%

Treatment of colorectal cancer by traditional Chinese medicine: prevention and treatment mechanisms

Sun,

Wei,

Wang

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

Colorectal cancer (CRC) is a significant global health burden, with high morbidity and mortality rates. It is often diagnosed at middle to advanced stage, affecting approximately 35% of patients at the time of diagnosis. Currently, chemotherapy has been used to improve patient prognosis and increase overall survival. However, chemotherapy can also have cytotoxic effects and lead to adverse reactions, such as inhibiting bone marrow hematopoiesis, causing digestive dysfunction, hand-foot syndrome, and even life-threatening conditions. In response to these adverse effects, researchers have proposed using Traditional Chinese Medicine (TCM) as an option to treat cancer. TCM research focuses on prescriptions, herbs, and components, which form essential components of the current research in Chinese medicine. The study and implementation of TCM prescriptions and herbs demonstrate its distinctive holistic approach to therapy, characterized by applying multi-component and multi-target treatment. TMC components have advantages in developing new drugs as they consist of single ingredients, require smaller medication dosages, have a precise measure of pharmacodynamic effects, and have a clear mechanism of action compared to TCM prescriptions and herbs. However, further research is still needed to determine whether TMC components can fully substitute the therapeutic efficacy of TCM prescriptions. This paper presents a comprehensive analysis of the research advancements made in TCM prescriptions, herbs, and components. The findings of this study can serve as a theoretical basis for researchers who are interested in exploring the potential of TCM for the treatment of colorectal cancer.

show abstract

PGC-1α promotes colorectal carcinoma metastasis through regulating ABCA1 transcription

Cited by 2 publications

References 47 publications

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases

Treatment of colorectal cancer by traditional Chinese medicine: prevention and treatment mechanisms

Contact Info

Product

Resources

About