PGC‐1α, a potential therapeutic target against kidney aging

Lee, Ga-Young; Uddin, Jamal; Kim, Yoojeong; Ko, Min-Ji; Yu, Inyoung; Ha, Hunjoo

doi:10.1111/acel.12994

Cited by 55 publications

(42 citation statements)

References 201 publications

(259 reference statements)

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“…Proliferation of VSMCs caused by vascular injury plays an important role in the formation of vascular lesions (Durham et al, 2018;Zhang C. et al, 2018). Peroxisome proliferatoractivated receptor g coactivator-1 (PGC-1) is a very important regulator of many biological processes such as energy metabolism (Islam et al, 2018;Lee et al, 2019). PGC-1b expression was decreased in the carotid artery of rats with balloon injury (Guo et al, 2013).…”

Section: Intimal Thickeningmentioning

confidence: 99%

Metformin and Vascular Diseases: A Focused Review on Smooth Muscle Cell Function

Mingying

et al. 2020

Front. Pharmacol.

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Metformin has been used in diabetes for more than 60 years and has excellent safety in the therapy of human type 2 diabetes (T2D). There is growing evidence that the beneficial health effects of metformin are beyond its ability to improve glucose metabolism. Metformin not only reduces the incidence of cardiovascular diseases (CVD) in T2D patients, but also reduces the burden of atherosclerosis (AS) in pre-diabetes patients. Vascular smooth muscle cells (VSMCs) function is an important factor in determining the characteristics of the entire arterial vessel. Its excessive proliferation contributes to the etiology of several types of CVD, including AS, restenosis, and pulmonary hypertension. Current studies show that metformin has a beneficial effect on VSMCs function. Therefore, this review provides a timely overview of the role and molecular mechanisms by which metformin acts through VSMCs to protect CVD.

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Section: Intimal Thickeningmentioning

confidence: 99%

Metformin and Vascular Diseases: A Focused Review on Smooth Muscle Cell Function

Mingying

et al. 2020

Front. Pharmacol.

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“…Mitochondrial biogenesis is mainly regulated by a set of nuclear encoded coactivators and transcription factors. Peroxisome proliferator–activated receptor γ coactivator 1α (PGC‐1α), which is critical for maintaining energy homeostasis, has been shown to play a key role in regulating mitochondrial biogenesis and function 41 . Decreased PGC‐1α expression and activity have been linked to cardiac ageing and the development of heart failure 42 .…”

Section: Discussionmentioning

confidence: 99%

Alginate oligosaccharide alleviates D‐galactose‐induced cardiac ageing via regulating myocardial mitochondria function and integrity in mice

Feng

Liu

Wang

et al. 2021

J Cellular Molecular Medi

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Ageing is a crucial risk factor for the development of age‐related cardiovascular diseases. Therefore, the molecular mechanisms of ageing and novel anti‐ageing interventions need to be deeply studied. Alginate oligosaccharide (AOS) possesses high pharmacological activities and beneficial effects. Our study was undertaken to investigate whether AOS could be used as an anti‐ageing drug to alleviate cardiac ageing. D‐galactose (D‐gal)‐induced C57BL/6J ageing mice were established by subcutaneous injection of D‐gal (200 mg·kg‐1·d‐1) for 8 weeks. AOS (50, 100 and 150 mg·kg‐1·d‐1) were administrated intragastrically for the last 4 weeks. As a result, AOS prevented cardiac dysfunction in D‐gal‐induced ageing mice, including partially preserved ejection fraction (EF%) and fractional shortening (FS%). AOS inhibited D‐gal‐induced up‐regulation of natriuretic peptides A (ANP), brain natriuretic peptide (BNP) and ageing markers p53 and p21 in a dose‐dependent manner. To further explore the potential mechanisms contributing to the anti‐ageing protective effect of AOS, the age‐related mitochondrial compromise was analysed. Our data indicated that AOS alleviated D‐gal‐induced cardiac ageing by improving mitochondrial biogenesis, maintaining the mitochondrial integrity and enhancing the efficient removal of impaired mitochondria. AOS also decreased the ROS production and oxidative stress status, which, in turn, further inhibiting cardiac mitochondria from being destroyed. Together, these results demonstrate that AOS may be an effective therapeutic agent to alleviate cardiac ageing.

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“…The transcriptional coactivator PGC-1α is a deacetylated substrate for SIRT1 and plays a critical role in mitochondrial biosynthesis and maintenance [ 49 , 50 ]. The PGC-1α protein, which is abundant in mitochondria-rich tissues, consists of 795 amino acids with a molecular weight of approximately 92 kDa [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Combined intake of blueberry juice and probiotics ameliorate mitochondrial dysfunction by activating SIRT1 in alcoholic fatty liver disease

Fan

Shen

et al. 2021

Nutr Metab (Lond)

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Background Mitochondrial dysfunction has been implicated as a significant factor in the liver disease process. Blueberry juice and probiotics (BP) synergistically improve liver function in alcoholic fatty liver disease (AFLD), although the mechanism for this effect was unclear. This study aims to investigate the effect and specific mechanisms of BP on AFLD. Methods C57/BL6 mice were randomly divided into seven groups: CG (control), MG (AFLD model), BJ (MG mice treated with blueberry), BJB (MG mice treated with BP), SI (AFLD mice treated with SIRT1 siRNA), BJSI (SI mice treated with blueberry), and BJBSI (SI mice treated with BP). The mice were fed an alcohol liquid diet for 10 days to establish the AFLD model, and subjected to BP and SIRT1 siRNA intervention for 10 days. Liver pathology was performed on day 11, and biochemical and molecular analyses of liver mitochondria were employed on day 12. Results BP significantly ameliorated hepatic mitochondrial injury, mitochondrial swelling, and hepatic necrosis in AFLD. BP alleviated hepatic mitochondrial dysfunction by increasing the expression of succinate dehydrogenase and cytochrome c oxidase, increasing respiratory control rate and the ADP/O ratio, and facilitating the synthesis of energy-related molecules. Besides, BP increased the expression of glutathione and superoxide dismutase, and inhibited malondialdehyde expression and reactive oxygen species activity. BP-induced sirtuin 1 (SIRT1), which activates peroxisome proliferator-activated receptor-gamma coactivator-1α, both of which mediate mitochondrial homeostasis. SIRT1 silencing suppressed the BP-induced changes in liver mitochondria, blunting its efficacy. Conclusions The ingredients of BP ameliorate hepatocyte mitochondrial dysfunction in AFLD mice.

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PGC‐1α, a potential therapeutic target against kidney aging

Cited by 55 publications

References 201 publications

Metformin and Vascular Diseases: A Focused Review on Smooth Muscle Cell Function

Metformin and Vascular Diseases: A Focused Review on Smooth Muscle Cell Function

Alginate oligosaccharide alleviates D‐galactose‐induced cardiac ageing via regulating myocardial mitochondria function and integrity in mice

Combined intake of blueberry juice and probiotics ameliorate mitochondrial dysfunction by activating SIRT1 in alcoholic fatty liver disease

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