Molecular quantum-dot cellular automata (QCA) is an emerging nanocomputing paradigm, which operates on electrostatic repulsion phenomena between two electrons to keep those apart at the maximum distance to a rest position for obtaining the highest finding probability. In the field of Quantum-dot Cellular Automata the digital logic gate approaches nearly about to nanometer in scale. In QCA quantum gates operate by the tunneling effect of electrons from one quantum dot to another dot through revealing its wave nature. The operating speed of the device gains the speed of light because the quantum tunneling occurs at the light speed. This paper compares two methodologies of quantum logic gate designing, those are universal T gate designing and conventional gate designing practice. One 22 cells 2x1 MUX is proposed which is designed by conventional method, that provides 20.35% optimization in area occupancy compared to the best reported designs. Furthermore, one 11 cells 2:1 MUX layout is proposed which achieves 33.33% area reduction compared to the best ever multiplexer designed in QCA technology.