PFOS levels in the blood and liver of a small insectivorous songbird near a fluorochemical plant

Dauwe, Tom; Vijver, Kristin Van de; Coen, Wim De; Eens, Marcel

doi:10.1016/j.envint.2006.11.014

Cited by 72 publications

(63 citation statements)

References 22 publications

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“…It has also been found that the liver is the primary target organ of PFOS in birds (Dauwe et al 2007;Nakayama et al 2008) and mammals (Butenhoff et al 2006;Guruge et al 2008;Cui et al 2009), while PFOA also accumulates at high concentrations in hepatic tissue of mammals (Cui et al 2009). Relatively higher liver concentrations of PFOS than in other human tissues have also been reported (Maestri et al 2006).…”

Section: Discussionmentioning

confidence: 96%

Biomonitoring perfluorinated compounds in Catalonia, Spain: concentrations and trends in human liver and milk samples

Kärrman

Domingo

Llebaria

et al. 2009

Environ Sci Pollut Res

141

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Section: Discussionmentioning

confidence: 96%

Biomonitoring perfluorinated compounds in Catalonia, Spain: concentrations and trends in human liver and milk samples

Kärrman

Domingo

Llebaria

et al. 2009

Environ Sci Pollut Res

141

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“…They reported that PFOS concentrations in blood were lower than those in liver. [18][19][20] Already in 1979 studies in rats showed that PFOS is well absorbed orally and accumulates primarily in the liver and, to a lesser extent, in the serum or plasma. [21] In contrast, some studies resulted in highest values in blood and lower values in liver.…”

Section: Analytical Challengesmentioning

confidence: 99%

Trends of polyfluoroalkyl compounds in marine biota and in humans

Sturm

Ahrens

2010

Environ. Chem.

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Environmental context. Polyfluoroalkyl compounds are used in a variety of industrial and consumer applications, including polymer production and for surface treatment of textiles and paper. Research over the last 10 years has shown that these compounds are ubiquitous environmental contaminants -they are extremely persistent, show toxic effects and accumulate in the food chain. We evaluate global, temporal and spatial trends of these important emerging contaminants.Abstract. This review gives an overview of existing knowledge of polyfluoroalkyl compounds (PFCs) in humans and in marine biota. Temporal trends and spatial distribution of PFCs were globally compared in humans, marine mammals, seabirds and fish. In general, PFC concentrations in the environment have increased significantly from the beginning of the production up to the 1990s. After the phase-out of perfluorooctane sulfonyl fluoride (POSF) production starting in 2000, PFC concentrations in humans generally decreased. In marine biota no clear temporal trends were observed. The temporal trends depended on the species, their trophic levels and the geographical locations. PFC patterns in humans and in marine wildlife species were compared regarding perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), their shorter and longer chain homologues (C 4 -C 15 ) and precursor compounds. Finally knowledge gaps were identified and recommendations for future work were presented.

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“…One possible reason for the vague trend in PFOA accumulation with varying salinity is the potential difference in uptake and depuration kinetics between sexes [19]. However, in the present study test fish were not sexually determined, and most studies in the literature that evaluated sex differences had been inconclusive [20][21][22].…”

Section: Uptake and Depuration Of Pfcsmentioning

confidence: 74%

Bioconcentration of perfluorinated compounds in blackrock fish, Sebastes schlegeli, at different salinity levels

Jeon

Kannan

Lim

et al. 2010

Enviro Toxic and Chemistry

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Bioconcentration of perfluorinated compounds (PFCs) was studied in a biphasic (uptake and elimination) study with blackrock fish, Sebastes schlegeli. The blackrock fish was acclimated to varying salinities over a two-week period before the present study. Among the four selected PFCs: perfluorooctane sulfonate (PFOS), perfluoro-octanoic acid (PFOA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA), PFUnDA accumulated significantly in serum, followed by PFDA, PFOS, and PFOA, in that order, while the accumulation profile in liver was PFOS > PFUnDA > PFDA > PFOA. Total PFC levels in plasma were approximately four times greater than those found in liver. The uptake and elimination rate constants (K(u) and K(e)) of PFCs decreased as salinity decreased, suggesting delayed diffusion of PFCs between water and fish, possibly associated with the osmolality gradient. A significant correlation was found between bioconcentration factors (BCF) of PFCs and salinity, except for PFOA, possibly resulting from the effects of salinity on biological responses and chemical activity of PFCs. Even though salinity did not affect the kinetics of PFC accumulation in serum and liver, the results provide useful information on the toxicokinetics of PFCs for saltwater fish.

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PFOS levels in the blood and liver of a small insectivorous songbird near a fluorochemical plant

Cited by 72 publications

References 22 publications

Biomonitoring perfluorinated compounds in Catalonia, Spain: concentrations and trends in human liver and milk samples

Biomonitoring perfluorinated compounds in Catalonia, Spain: concentrations and trends in human liver and milk samples

Trends of polyfluoroalkyl compounds in marine biota and in humans

Bioconcentration of perfluorinated compounds in blackrock fish, Sebastes schlegeli, at different salinity levels

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