Biomonitoring perfluorinated compounds in Catalonia, Spain: concentrations and trends in human liver and milk samples

Kärrman, Anna; Domingo, José L.; Llebaria, Xavier; Nadal, Martí; Bigas, Esther; Bavel, Bert van; Lindström, Gunilla

doi:10.1007/s11356-009-0178-5

Cited by 141 publications

(60 citation statements)

References 43 publications

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“…PFOS and other PFSAs are widely distributed in the global environment [34][35][36][37][38], biota [39][40][41][42][43][44] and humans [15,[45][46][47][48][49][50][51][52]. Due to the dominance of POSF-based products historically, PFOS is usually the most abundant PFSA found.…”

Section: Perfluoroalkane Sulfonic Acids (Pfsas) and Their Precursorsmentioning

confidence: 99%

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

Land¹,

Wit²,

Bignert³

et al. 2018

Environ Evid

162

122

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Background: There is a concern that continued emissions of man-made per-and polyfluoroalkyl substances (PFASs) may cause environmental and human health effects. Now widespread in human populations and in the environment, several PFASs are also present in remote regions of the world, but the environmental transport and fate of PFASs are not well understood. Phasing out the manufacture of some types of PFASs started in 2000 and further regulatory and voluntary actions have followed. The objective of this review is to understand the effects of these actions on global scale PFAS concentrations.Methods: Searches for primary research studies reporting on temporal variations of PFAS concentrations were performed in bibliographic databases, on the internet, through stakeholder contacts and in review bibliographies. No time, document type, language or geographical constraints were applied in the searches. Relevant subjects included human and environmental samples. Two authors screened all retrieved articles. Dual screening of 10% of the articles was performed at title/abstract and full-text levels by all authors. Kappa tests were used to test consistency. Relevant articles were critically appraised by four reviewers, with double checking of 20% of the articles by a second reviewer. Meta-analysis of included temporal trends was considered but judged to not be appropriate. The trends were therefore discussed in a narrative synthesis.

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Section: Perfluoroalkane Sulfonic Acids (Pfsas) and Their Precursorsmentioning

confidence: 99%

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

Land¹,

Wit²,

Bignert³

et al. 2018

Environ Evid

162

122

View full text Add to dashboard Cite

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“…[51][52][53] Mean concentrations in breast milk from different countries were summarised by several authors. [54][55][56] Highest PFOS concentrations (medians) were found in breast milk from Hungary with ,330 ng L À1 (n ¼ 13; 1996-97) [57] followed by Japan with 196 ng L À1 (n ¼ 24; 1999), [54] Sweden with 166 ng L À1 (n ¼ 12; 2004), [51] Germany with 119 ng L À1 (n ¼ 57; 2006), [57] Malaysia with 111 ng L À1 (n ¼ 13; 2003), [54] USA with 106 ng L À1 (n ¼ 43; 2004), [52] Philippines with 104 ng L À1 (n ¼ 24; 2002-04), [54] China with 100 ng L À1 (n ¼ 19; 2004), [58] whereas the PFOS concentrations in breast milk from Indonesia (n ¼ 20; 2001), Vietnam (n ¼ 40; 2000-01), Cambodia (n ¼ 24; 2002) and India (n ¼ 39; 2002-05) were below 100 ng L À1 . [54] It is noticeable that the high PFOS values in milk from Hungary and Japan were found in samples taken before 2000, whereas the lower values were related to samples taken after 2000.…”

Section: Levels and Trends In Humansmentioning

confidence: 99%

Trends of polyfluoroalkyl compounds in marine biota and in humans

Sturm

Ahrens

2010

Environ. Chem.

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Environmental context. Polyfluoroalkyl compounds are used in a variety of industrial and consumer applications, including polymer production and for surface treatment of textiles and paper. Research over the last 10 years has shown that these compounds are ubiquitous environmental contaminants -they are extremely persistent, show toxic effects and accumulate in the food chain. We evaluate global, temporal and spatial trends of these important emerging contaminants.Abstract. This review gives an overview of existing knowledge of polyfluoroalkyl compounds (PFCs) in humans and in marine biota. Temporal trends and spatial distribution of PFCs were globally compared in humans, marine mammals, seabirds and fish. In general, PFC concentrations in the environment have increased significantly from the beginning of the production up to the 1990s. After the phase-out of perfluorooctane sulfonyl fluoride (POSF) production starting in 2000, PFC concentrations in humans generally decreased. In marine biota no clear temporal trends were observed. The temporal trends depended on the species, their trophic levels and the geographical locations. PFC patterns in humans and in marine wildlife species were compared regarding perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), their shorter and longer chain homologues (C 4 -C 15 ) and precursor compounds. Finally knowledge gaps were identified and recommendations for future work were presented.

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“…PFOS and other PFSAs are widely distributed in the global environment [52][53][54][55][56], biota [57][58][59][60][61][62] and humans [29,[63][64][65][66][67][68][69][70]. Due to the dominance of POSF-based products historically, PFOS is usually found to be the most abundant PFSA.…”

Section: Perfluoroalkane Sulfonic Acids (Pfsas) and Their Precursorsmentioning

confidence: 99%

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review protocol

et al. 2015

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Background: There is a growing concern in Sweden and elsewhere that continued emissions of per-and polyfluoroalkyl substances (PFASs) may cause environmental as well as human health effects. PFASs are a broad class of man-made substances that have been produced and used in both commercial products and industrial processes for more than 60 years. Although the production and use of some PFASs has been phased-out in some parts of the world, it is not known what effect these actions to date have had on PFAS concentrations in the environment. Owing to the wide diversity of PFASs, it is difficult to generalize their properties, environmental fate and production histories. However, the strength and stability of the C-F bond renders the perfluoroalkyl moieties resistant to heat and environmental degradation. Several PFASs are now occurring even in very remote areas in large parts of the world, but the environmental transport and fate of substances within this group is not well understood. A systematic review may be able to determine whether the concentrations of these substances in different environments are changing in any particular direction with time, and whether the phase-outs have had any effects on the concentration trends. Methods: Searches for primary research studies reporting on temporal variations of PFAS concentrations in the environment will be performed in the scientific literature as well as in other reports. Relevant samples include both abiotic and biological samples including humans. No particular time, document type, language or geographical constraints will be applied. Two authors will screen all retrieved articles. Double screening of about 10% of the articles will be performed by all authors at both title/abstract and full-text levels. Kappa tests will be used to test if the screening is consistent. Relevant articles will be critically appraised by four authors (double checking of 25% of the articles). Quality assessment will focus on selection bias, dating of samples, sample integrity and analytical procedures. Data synthesis will be based on statistical analysis of temporal concentration trends.

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Biomonitoring perfluorinated compounds in Catalonia, Spain: concentrations and trends in human liver and milk samples

Abstract: Interestingly, the potential accumulation difference for PFCs with different chain lengths might be of great importance for risk assessment. Continuing studies on the distribution of different PFCs in human tissue are therefore justified.

Cited by 141 publications

References 43 publications

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

Trends of polyfluoroalkyl compounds in marine biota and in humans

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review protocol

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