PFOA is associated with diabetes and metabolic alteration in US men: National Health and Nutrition Examination Survey 2003–2012

He, Xiaowei; Liu, Yuanxin; Xu, Bo; Gu, Liya; Tang, Wei

doi:10.1016/j.scitotenv.2017.12.186

Cited by 99 publications

(51 citation statements)

References 75 publications

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“…Moreover, the Odds Ratio of hypertension was 2.62 when comparing the 80th and 20th percentiles of the PFOA distribution. In contrast, He et al (n = 7543) reported no signi cant association with blood pressure, but blood pressure was not the primary outcome of this study [18]. The other two studies focused on children and adolescents with background exposure to PFAS [11,17], yielding con icting results: while Geiger et al (n = 1655) found no evidence of an association between serum PFAS and blood pressure or hypertension [17], Ma et al (n = 2251) found a positive signi cant association between PFOS and DBP among males [11].…”

Section: Discussioncontrasting

confidence: 75%

“…Literature on association between PFAS exposure and blood pressure and/or hypertension (de ned as self-reported diagnosis or treatment or elevated measured blood pressure) is relatively limited, with contradictory ndings. Some large cross-sectional studies were conducted on representative samples of the US general population with background exposure using data from the NHANES survey [11,12,17,18]. Among 2934 adults, Min et al showed a signi cant increase in SBP, but not DBP, associated with increasing PFOA concentrations [12].…”

Section: Discussionmentioning

confidence: 99%

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Perfluoroalkyl Substances Are Associated With Elevated Blood Pressure and Hypertension in Highly Exposed Young Adults

Pitter

Jeddi

Barbieri

et al. 2020

Preprint

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Background Residents in a large area of North-Eastern Italy were exposed to perfluoroalkyl substances (PFAS) via drinking water. Studies on the association between PFAS and blood pressure levels are limited and results inconsistent. Using cross-sectional data from the Regional health surveillance program, we aimed to quantify the associations between PFAS serum concentrations and blood pressure and hypertension prevalence. Methods The study included 16,224 individuals aged 20-39 years. Pregnant women (n=327), or individuals with missing information on the selected covariates (n=111) were excluded, leaving 15,786 subjects. Hypertension was defined as any self-reported diagnosis, use of antihypertensive drugs, or elevated systolic blood pressure (SBP)/diastolic blood pressure (DBP). Generalized additive models were used to investigate the relation between each PFAS (perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA)) ln transformed and by decile, and SBP, DBP, hypertension, adjusted for potential confounders. Results Both SBP and DBP increased significantly with an increase in the ln-transformed serum PFAS concentrations in a monotonic way. The predicted increase in SBP and DBP were 1.54 mmHg (95%CI 0.61-2.47), 1.60 mmHg (95%CI 0.92-2.27) from lowest to highest decile of PFOA. The associations were stronger for SBP in men and DBP in women. One unit increase in each natural log transformed PFAS was positively associated with an increased odd of hypertension in men: PFOA OR=1.06 (1.01-1.11), PFOS OR=1.13 (1.03-1.23), PFHxS OR=1.08 (1.02-1.15), PFNA OR=1.20 (1.02-1.40). Conclusions Our findings suggest that serum PFAS concentrations were associated with moderately increased systolic and diastolic blood pressure in a large highly exposed young adult population. Although the magnitude of the observed effect was relatively small, if confirmed it would be of clinical significance since even small increases in blood pressure levels at population level may be associated to a raised risk of adverse outcomes such as cardiovascular disease and target organ damage.

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Section: Discussioncontrasting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Perfluoroalkyl Substances Are Associated With Elevated Blood Pressure and Hypertension in Highly Exposed Young Adults

Pitter

Jeddi

Barbieri

et al. 2020

Preprint

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“…Thus, prenatal exposure to some PCBs has been associated with increased fasting insulin levels in girls at 5 years of age (Tang-Peronard et al 2015), while PCBs and organochlorine exposure has been related to decreased insulin levels in newborns (Debost-Legrand et al 2016). Regarding perfluorinated compounds (PFCs), PFOA exposure has been linked to elevated diabetes prevalence in adults (He et al 2017) and elderly (Lind et al 2014), while an association between PFOA levels and impaired β-cell function has been observed in adulthood (Domazet et al 2016). Perfluoroalkoxy alkanes exposure during pregnancy was positively related to impaired gestational glucose tolerance (Matilla-Santander et al 2017).…”

Section: Edcs and T2dmentioning

confidence: 99%

Mitochondria as target of endocrine-disrupting chemicals: implications for type 2 diabetes

Marroquí

Tudurí

Alonso-Magdalena

et al. 2018

Journal of Endocrinology

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Type 2 diabetes is a chronic, heterogeneous syndrome characterized by insulin resistance and pancreatic β-cell dysfunction or death. Among several environmental factors contributing to type 2 diabetes development, endocrine-disrupting chemicals (EDCs) have been receiving special attention. These chemicals include a wide variety of pollutants, from components of plastic to pesticides, with the ability to modulate endocrine system function. EDCs can affect multiple cellular processes, including some related to energy production and utilization, leading to alterations in energy homeostasis. Mitochondria are primarily implicated in cellular energy conversion, although they also participate in other processes, such as hormone secretion and apoptosis. In fact, due to mitochondria involvement in so many crucial cellular processes in metabolic relevant tissues, mitochondrial dysfunction has been linked to different metabolic diseases, including insulin resistance and type 2 diabetes. Herein, we review the main mechanisms whereby metabolism-disrupting chemical (MDC), a subclass of EDCs that disturbs energy homeostasis, cause mitochondrial dysfunction, thus contributing to the establishment of insulin resistance and type 2 diabetes. We conclude that MDC-induced mitochondrial dysfunction, which is mainly characterized by perturbations in mitochondrial bioenergetics, biogenesis, and dynamics, excessive reactive oxygen species production, and activation of the mitochondrial pathway of apoptosis, seems to be a relevant mechanism linking MDCs to type 2 diabetes development.

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“…This restricted production and use on PFOS and initiated global research on a broader list of per and polyfluoroalkyl substances (PFAS). Finding ways to manage PFAS in the environment is a clear focus for many stakeholders and something that has gained intensity because of a combination of forces: Regulatory developments such as the long‐term health advisory in the U.S. Environmental Protection Agency (USEPA ), regulations in Australia and Europe, and the review of perfluorooctanoic acid (PFOA) and perfluorohexane sulfonic acid (PFHxS) for inclusion in the Convention. Rapidly evolving toxicology and epidemiological research (Frisbee et al ; Steenland et al ; Halldorsson et al ; Danish Ministry of the Environment ; Mastrantonio et al 2017; Post et al ; He et al ). Public awareness due to detection in groundwater resources used for drinking water (Hu et al ). The fact that there are more than 3000 compounds including the perfluoroalkyl group in the class of chemical termed PFAS (Wang et al ). …”

Section: Introductionmentioning

confidence: 99%

“…• Regulatory developments such as the long-term health advisory in the U.S. Environmental Protection Agency (USEPA 2016 ), regulations in Australia and Europe, and the review of perfluorooctanoic acid (PFOA) and perfluorohexane sulfonic acid (PFHxS) for inclusion in the Convention. • Rapidly evolving toxicology and epidemiological research (Frisbee et al 2009 ;Steenland et al 2010 ;Halldorsson et al 2012 ; Danish Ministry of the Environment 2015 ; Mastrantonio et al 2017 ;Post et al 2017 ;He et al 2018 ). • Public awareness due to detection in groundwater resources used for drinking water (Hu et al 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Water Treatment Technologies for PFAS: The Next Generation

Horst¹,

McDonough²,

Ross³

et al. 2018

Groundwater Monitoring Rem

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PFOA is associated with diabetes and metabolic alteration in US men: National Health and Nutrition Examination Survey 2003–2012

Cited by 99 publications

References 75 publications

Perfluoroalkyl Substances Are Associated With Elevated Blood Pressure and Hypertension in Highly Exposed Young Adults

Perfluoroalkyl Substances Are Associated With Elevated Blood Pressure and Hypertension in Highly Exposed Young Adults

Mitochondria as target of endocrine-disrupting chemicals: implications for type 2 diabetes

Water Treatment Technologies for PFAS: The Next Generation

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