Peutz‐Jeghers syndrome with osseous metaplasia of the intestinal polyps

Narita, Takeo; Ohnuma, Hiroyuki; Yokoyama, Shinichi

doi:10.1111/j.1440-1827.1995.tb03473.x

Cited by 21 publications

(9 citation statements)

References 20 publications

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“…In fact, although a few cases of ossification have been reported in Peutz-Jeghers polyposis or colorectal cancer, ossification in the gastrointestinal tract is extremely rare [7, 8]. Since heterotopic ossification commonly occurs as a complication of trauma [9], the process of wound healing after traumatic injury at the anastomotic region may have induced heterotopic ossification, as well as the incorporation of rectal mucosa into the bone and surrounding stromal tissues in our patient.…”

Section: Discussionmentioning

confidence: 80%

Rectal cancer developing from an anastomotic site 18 years after resection due to intussusception caused by Peutz-Jeghers polyposis in a 31-year-old man: a case report

et al. 2018

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BackgroundPeutz-Jeghers syndrome (PJS) is an autosomal dominant disorder characterized by hamartomatous polyposis of the gastrointestinal tract. It is associated with a high risk of malignancy in the gastrointestinal tract, as well as in other organs. We report a case of colon cancer at the anastomotic site that occurred 18 years after high anterior resection of the rectum for intussusception caused by Peutz-Jeghers polyposis.Case presentationA 31-year-old man with PJS, who had undergone high anterior resection of the rectum for intussusception at the age of 12, presented to our hospital complaining of hematochezia. Colonoscopy revealed a hemorrhagic tumor protruding from the anastomotic site, which was histologically diagnosed as an adenocarcinoma. We performed a low anterior resection of the rectum including the anastomotic site, with combined resection of the strongly adherent ileum. Histological examination revealed that the adenocarcinoma had developed from the submucosal area, where the normal rectal mucosa had been incorporated into the stromal and bone tissues, resulting in heterotopic ossification in the anastomotic region. These findings suggested that the reconstructive surgical procedure or postoperative complications, such as anastomotic leakage, had formed the cavity where the cancer had developed.ConclusionsWe concluded that the cancer might be derived from the rectal mucosa with malignant potential that was present in the anastomotic region and exacerbated by the presence of chronic inflammation in the cavity after the patient’s initial operation.

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Section: Discussionmentioning

confidence: 80%

Rectal cancer developing from an anastomotic site 18 years after resection due to intussusception caused by Peutz-Jeghers polyposis in a 31-year-old man: a case report

et al. 2018

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“…All the polyps were larger than 10 mm in diameter. [1][2][3][4][5][6][7][8] Three were inflammatory polyps, two juvenile polyps, and one case of Peutz Jeghers syndrome. 5 lesions demonstrated mucin deposition.…”

Section: Discussionmentioning

confidence: 99%

Bone in intestinal polyp-a curious observation

Bhawna

Datta

Mukherjee

et al. 2013

Bangladesh J Med Sci

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We report rare phenomena of ossification in benign colon polyp. An adult woman presented with occasional bleeding per rectum for which she was investigated. A polypoid rectal swelling was detected and histolopathology revealed an inflammatory polyp with osteoid formation. The case is presented for its rarity and available literature is reviewed. DOI: http://dx.doi.org/10.3329/bjms.v12i4.16669 Bangladesh Journal of Medical Science Vol. 12 No. 04 October 13 Page 453-455

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“…This is an unexpected variation of the usual histological features encountered in colorectal TSA. In 1939, Dukes described four cases of OM in colonic adenocarcinoma; since then, it has been described in both benign and malignant GIT lesions, but the rectal region is particularly affected [1,3,8]. …”

Section: Discussionmentioning

confidence: 99%

“…However, mesenchymal metaplasia, particularly osseous metaplasia (OM), is a rare and incidental finding in the GIT and is composed of histologically benign bone tissue [1-3]. Fewer than 100 cases have been described in the literature.…”

Section: Introductionmentioning

confidence: 99%

Traditional serrated adenoma of the sigmoid colon with osseous metaplasia: a case report

Montalvo

Beltrán²,

Redrobán

2012

J Med Case Reports

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IntroductionOsseous metaplasia in the gastrointestinal tract is a rare phenomenon.Case presentationWe present the case of a 62-year-old Hispanic man with two colonic polypoid lesions, one of which, upon resection and histopathological examination, was found to be a traditional serrated adenoma with a focus of stromal osseous metaplasia.ConclusionsOur patient’s case is the third report of stromal osseous metaplasia in a traditional serrated adenoma of the sigmoid colon.

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Peutz‐Jeghers syndrome with osseous metaplasia of the intestinal polyps

Cited by 21 publications

References 20 publications

Rectal cancer developing from an anastomotic site 18 years after resection due to intussusception caused by Peutz-Jeghers polyposis in a 31-year-old man: a case report

Rectal cancer developing from an anastomotic site 18 years after resection due to intussusception caused by Peutz-Jeghers polyposis in a 31-year-old man: a case report

Bone in intestinal polyp-a curious observation

Traditional serrated adenoma of the sigmoid colon with osseous metaplasia: a case report

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