Petroleum Ether Extract of Cissus Quadrangularis (LINN) Stimulates the Growth of Fetal Bone during Intra Uterine Developmental Period: A Morphometric Analysis

Potu, Bhagath Kumar; Rao, Muddanna S.; Kutty, N. Gopalan; Bhat, Kumar Mr; Chamallamudi, Mallikarjuna Rao; Nayak, Soubhagya R.

doi:10.1590/s1807-59322008000600018

Cited by 29 publications

(24 citation statements)

References 28 publications

(24 reference statements)

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“…77 When CQ was given to pregnant rats, the bones of the pups showed increased total length. 78 CQ stimulates biomineralization through the MAPKinase pathway. 79 In human SaOS-2 cells, CQ increases ALP and mineralization.…”

Section: Family Vitaceaementioning

confidence: 99%

Alternative therapies for the prevention and treatment of osteoporosis

2012

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Osteoporosis is a medical condition that affects millions of men and women. People with this condition have low bone mass, which places them at increased risk for bone fracture after minor trauma. The surgeries and treatments required to repair and heal bone fractures involve long recovery periods and can be expensive. Because osteoporosis occurs frequently in the elderly, the financial burden it places on society is likely to be large. In the United States, the Food and Drug Administration has approved several drugs for use in the prevention and treatment of osteoporosis. However, all of the currently available agents have severe side effects that limit their efficacy and underscore the urgent need for new treatment options. One promising approach is the development of alternative (nonpharmaceutical) strategies for bone maintenance, as well as for the prevention and treatment of osteoporosis. This review examines the currently available nonpharmaceutical alternatives that have been evaluated in in vitro and in vivo studies. Certain plants from the following families have shown the greatest benefits on bone: Alliceae, Asteraceae, Thecaceae, Fabaceae, Oleaceae, Rosaceae, Ranunculaceae, Vitaceae, Zingiberaceae. The present review discusses the most promising findings from studies of these plant families.

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Section: Family Vitaceaementioning

confidence: 99%

Alternative therapies for the prevention and treatment of osteoporosis

2012

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“…Several studies showed the capacity of CQ to reduce bone loss, as evidenced by the bone weight gain, density, strength, and calcium content in ovariectomised or orchidectomized animals (Jadhav et al, 2016;Potu et al, 2009). Maternal administration of CQ extract during pregnancy stimulated the development of fetal bone growth during the intra-uterine period in rats (Potu et al, 2008).…”

Section: Animal Studiesmentioning

confidence: 95%

Osteoprotective Medicinal Plants - Part 1 (A Human Clinical Evidence-Based Review)

Dragoș¹,

Gîlcă²,

Găman³

et al. 2017

Afr J Tradit Complement Altern Med

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Background. Osteoporosis is a bone metabolic disease affecting a large percentage of aging population, which leads to an increased risk of fractures and has a negative impact on life quality. The available treatments for osteoporosis are effective, but are associated with several severe adverse reactions, hence the interest for alternative treatments devoid of such redoubtable side effects. Medicinal plants represent a viable resource for new therapeutic agents. The purpose of this review is to provide an overview about the medicinal plants that have been reported to have antiosteoporotic effects in human clinical studies. Materials and Methods. Relevant studies found in PubMed database, pertaining to efficacy in humans, mechanism of action, osteoactive phytochemicals and safety, were selected. For the inquiry, keywords such as "medicinal plant", "osteoporosis", "bone", "fracture", "osteoclast" and "osteoblast" were used in various combinations. The information extracted was integrated with the traditional knowledge on the correspondent medicinal plants. List of abbreviations: BMD-bone mineral density; CQ-Cissus quadrangularis; CR-Cimicifuga racemose; ESEleutherococcus senticosus; IGF-insulin like growth factor; OPG-osteoprotegerin; OVX-M -ovariectomized mice; OVX-R-ovariectomized rats; PC -Pueraria candollei; PL -Pueraria lobate; PN-Panax notoginseng; RANK-receptor activator of NF-kB; RANKL-receptor activator of NF-kB ligand; ROS -reactive oxygen species; Runx 2-runt related transcription factor 2; SM-Salvia milthiorriza Results. Eight medicinal plants (Cimicifuga racemosa, IntroductionOsteoporosis and osteopenia (low bone density) are bone metabolic diseases affecting a large percentage of aging population, increasing the risk of fractures and having a negative impact on quality of life patients. Risk factors for osteoporosis are: hormonal related risk factors (menopausal and andropausal hormonal disturbances, early menopause, Article HistoryReceived: Jan. 5, 2017. Revised Received: Apr. 7, 2017. Accepted Apr. 12, 2017. Published Online: Nov. 15, 2017 103 hyperparathyroidism, hyperthyroidism), environmental related risk factors (e.g. dioxin-related compounds, heavy metals), nutrition-related risk factors (vitamin D, calcium deficiencies), lifestyle related risk factors (e.g. smoking, sedentarism), drugs (corticosteroids, anticonvulsants, aromatase inhibitors, gonadotropin-releasing hormone agonists), advanced age, female gender (Gonzalez-Macias et al., 2015;Paunescu et al., 2013;Rzymski et al., 2015).Osteoporosis is caused by disturbances of bone remodeling process. The bone tissue is undergoing permanent build-up by osteoblasts and breakdown by osteoclasts. A good dynamic balance between the osteoblastogenesis and osteoclastogenesis is the key for a bone matrix of a high quality. The disbalance occurs especially when the breakdown process overwhelms the building process, being triggered by the risk factors (Leung and Siu, 2013).There are several factors important for osteoblastogenesis, such as run...

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“…[4041] We observed that the prenatal exposure of PECQ can significantly improve bone mass in the offspring at their adult age (unpublished data). Therefore, the present study was designed to investigate the protective effect of PECQ on diabetes-induced delayed fetal skeletal ossification.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of Cissus quadrangularis Linn. on diabetes induced delayed fetal skeletal ossification

Sirasanagandla

Pai

Potu

et al. 2014

J Ayurveda Integr Med

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Background:Delayed fetal skeletal ossification is one of the known complications of maternal diabetes.Objective:The present study was designed to evaluate the protective role of petroleum ether extract of Cissus quadrangularis (PECQ) on diabetes-induced delayed fetal skeletal ossification.Materials and Methods:Female Wistar rats were rendered diabetic with streptozotocin (STZ, 40 mg/kg, intraperitonial) before mating. After confirmation of pregnancy, the pregnant rats were divided into three groups: normal control group, diabetic control group, and diabetic + CQ group. The diabetic + CQ group pregnant rats were treated with PECQ (500 mg/kg body weight) throughout their gestation period. Immediately after delivery, pups were collected from all three groups and processed for alizarin red S–alcian blue staining in order to examine the pattern of skeletal ossification.Results:Fewer ossification centers and decreased extent of ossification of forelimb and hindlimb bones were observed in the neonatal pups of diabetic control group as compared to those in the normal control group. PECQ pretreatment significantly restored the ossification centers and improved the extent of ossification of forelimb and hindlimb bones in the neonatal pups of diabetic + CQ group as compared to those in the diabetic control group.Conclusions:The results suggested that PECQ treatment is effective against diabetes-induced delayed fetal skeletal ossification. However, further studies on the isolation and characterization of active constituents of PECQ, which can cross the placental barrier and are responsible for the bone anabolic activity are warranted.

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Petroleum Ether Extract of Cissus Quadrangularis (LINN) Stimulates the Growth of Fetal Bone during Intra Uterine Developmental Period: A Morphometric Analysis

Cited by 29 publications

References 28 publications

Alternative therapies for the prevention and treatment of osteoporosis

Alternative therapies for the prevention and treatment of osteoporosis

Osteoprotective Medicinal Plants - Part 1 (A Human Clinical Evidence-Based Review)

Protective effect of Cissus quadrangularis Linn. on diabetes induced delayed fetal skeletal ossification

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