Voluminous Early Cretaceous volcanic rocks in the central Lhasa subterrane provide an ideal opportunity for understanding the mantle-crust interaction and tectonicmagmatic evolution of the Lhasa Terrane. Here, we report zircon U-Pb ages, geochemical and Sr-Nd-Pb-Hf isotopic data for the Early Cretaceous volcanic rocks, including high-silica rhyolites (117.2 ± 1.1 Ma) and contemporaneous andesites (114.1 ± 0.8 Ma) in the Sailipu area, central Lhasa subterrane. All these rocks show enriched light rare earth elements (LREE), and radioactive heat-generating elements (e.g., Th, U, K, and Pb) but depleted high-field-strength elements (HFSEs, e.g., Nb, Ta, P, and Ti). The different bulk-rock Sr-Nd-Pb and zircon Hf isotopic compositions of the rhyolites and andesites suggest that these rocks have distinct magma sources and petrogenetic history rather than an identical source involving assimilation-fractional crystallization process. The Sailipu high-silica rhyolites exhibit the characteristics of fractional crystallization and have varying zircon ε Hf (t) values (−12.2 to +5.2), negative ε Nd (t) values (−9.5 to −1.6), high and variable initial Sr isotopic compositions ([ 87 Sr/ 86 Sr] i = 0.7047-0.7116) and radiogenic Pb isotopic signatures ( 206 Pb/ 204 Pb = 18.784-18.802, 207 Pb/ 204 Pb = 15.722-15.737, and 208 Pb/ 204 . A combined process of magma mixing (involving crustal-derived felsic melts and mantle-derived mafic melts) and subsequent fractional crystallization were mainly responsible for the formation of these high-silica rhyolites. The Sailipu andesites show more enriched Sr-Nd isotopic compositions [( 87 Sr/ 86 Sr) i = 0.7088-0.7154, ε Nd (t) = −9.9 to −6.7] relative to rhyolites, and