Petri Net modelling approach for analysing the behaviour of
 
 Wnt/
 
 
 ‐catenin
 
 and
 
 Wnt/
 
 
 Ca
 2+
 
 signalling pathways in arrhythmogenic right ventricular cardiomyopathy

Azim, Nazia; Ahmad, Jamil; Iqbal, Nadeem; Siddiqa, Amnah; Majid, Abdul; Ashraf, Javaria; Jalil, Fazal

doi:10.1049/iet-syb.2020.0038

Cited by 3 publications

(1 citation statement)

References 48 publications

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“…It is important to note that the biological Regulatory Network of DENGUE pathways is a unique contribution in and of itself [27]. We developed it following a thorough literature search of the relevant molecular entities and interactions, and then we methodically abstracted them as we have done in previous work [12].…”

Section: Abstract Of Brn's Denv Signaling Pathwaysmentioning

confidence: 99%

Static Analysis of Dengue Biological Regulatory Network’s

et al. 2023

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DENGUE is an acute viral illness caused by the RNA virus of the family Flaviviridae and spread by Aedes mosquitoes. Intense dengue is a spreading cause of serious disease and death in some ’Asian and south American’ countries. Pathogenesis is associated with amended functioning of our innate immune system during infection. Toll Like Receptor is influential for the involucre of innate immunity able to cause of Dengue infection disease like pattern receptor recognition. Toll like receptor induces by injuries of a certain severity arbitrate activation of interferons and Fc receptor arbitrate involucre of cytokines. Clearance of Dengue virus is associated with interferons protein however regulatory mechanisms have been adopted against this modified effect. The clearance considers being a steady state known to be characterized low threshold level of DENV. The pathogenic state is characterized by high threshold level of SOCS. SOCS protein is also induced due to the interferon and cytokine amended signaling which can subsequently play its part in the regulation of interferon and cytokine production. Our hypothesis in this research the innate immunity system is associated between the pathogenesis of Dengue virus and the SOCS amended inhibition. We used the static formalism model of the biological regulatory network of Toll-like receptor induced by the pathogenesis of dengue amended signaling pathway. A model verification method used in GINsim was used to deduce the logical parameters for the qualitative modelling. Therefore, a multidisciplinary and translational study, constructed a formal model constraints approach with a static and integrative computational analysis, which may identify new immunopathological mechanisms and biomarkers for differential diagnosis, opening the way for the development of specific therapies that will reduce mortality and induced morbidity by Dengue virus.

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Section: Abstract Of Brn's Denv Signaling Pathwaysmentioning

confidence: 99%

Static Analysis of Dengue Biological Regulatory Network’s

et al. 2023

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Targeting NAD+: is it a common strategy to delay heart aging?

et al. 2022

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Heart aging is the main susceptible factor to coronary heart disease and significantly increases the risk of heart failure, especially when the aging heart is suffering from ischemia-reperfusion injury. Numerous studies with NAD+ supplementations have suggested its use in anti-aging treatment. However, systematic reviews regarding the overall role of NAD+ in cardiac aging are scarce. The relationship between NAD+ signaling and heart aging has yet to be clarified. This review comprehensively summarizes the current studies on the role of NAD+ signaling in delaying heart aging from the following aspects: the influence of NAD+ supplementations on the aging heart; the relationship and cross-talks between NAD+ signaling and other cardiac aging-related signaling pathways; Importantly, the therapeutic potential of targeting NAD+ in delaying heart aging will be discussed. In brief, NAD+ plays a vital role in delaying heart aging. However, the abnormalities such as altered glucose and lipid metabolism, oxidative stress, and calcium overload could also interfere with NAD+ function in the heart. Therefore, the specific physiopathology of the aging heart should be considered before applying NAD+ supplementations. We believe that this article will help augment our understanding of heart aging mechanisms. In the meantime, it provides invaluable insights into possible therapeutic strategies for preventing age-related heart diseases in clinical settings.

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A Static Analysis ofWnt/β-Catenin andWnt/Ca²⁺Biological Regulatory Networks for ARVC Using Automata Network Model

et al. 2021

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The Wnt-activated β-catenin and Ca 2+ ions play a critical role in the regulation of physiology of cardiomyocytes. The dysregulation of both the components causes the replacement of myocardial mass right ventricle with fibrous and adipose tissue which results in the condition of Arrhythmogenic Right ventricular Cardiomyopathy (ARVC). The major hurdle in ARVC treatment is lack of effective therapies targeting the underlying root molecular biomarkers of pathogenesis. Despite major advancements in interpreting the mechanism of ARVC etiology, the dynamics of molecular links in underlying biological machinery are still being delineated. Previously, formal methods based computational modeling techniques including kinetic logic, Petri Nets, hybrid automata and static analysis have greatly contributed in increasing our comprehension to decipher the molecular systems dynamics. It has allowed the identification of biomarkers which can be utilized for target-based therapies owing to meticulous biological abstractions along with implementing reference map that confines together the discrete biological insights. In this study, we have performed the static analysis of the Biological Regulatory Networks (BRNs) of the Wnt/β-catenin and Wnt/Ca 2+ signaling pathways to identify the significant biomarkers for ARVC. The abstracted qualitative models of afore mentioned BRNs are first constructed in GINsim software tool and then these models are converted into Automata Network (ANs) Models using Pint software tool. The fix point analysis is performed which contributed in pinpointing the possible therapeutic strategies for ARVC treatment by identification of drug targets such as Gsk3, Ck1 and Axin in Wnt/β-catenin AN and Bak & Bax, Parp, mCalpain, JNk and CIn in Wnt/Ca 2+ AN. Moreover, the Bcl2 gene is identified as novel therapeutic remedy in both the ANs of ARVC. The Bcl2 gene prevents the cardiac apoptosis via positive regulation of Wnt in Wnt/β-catenin AN and through inhibition of Bak & Bax (apoptotic component) in Wnt/Ca 2+ AN.The current study tends to fulfill the scientific gap between wet lab studies and provides cost effective and time saving computational strategies for an effectual treatment for deadly diseases like ARVC.

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Petri Net modelling approach for analysing the behaviour of Wnt/ ‐catenin and Wnt/ Ca ²⁺ signalling pathways in arrhythmogenic right ventricular cardiomyopathy

Cited by 3 publications

References 48 publications

Static Analysis of Dengue Biological Regulatory Network’s

Static Analysis of Dengue Biological Regulatory Network’s

Targeting NAD+: is it a common strategy to delay heart aging?

A Static Analysis ofWnt/β-Catenin andWnt/Ca²⁺Biological Regulatory Networks for ARVC Using Automata Network Model

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Petri Net modelling approach for analysing the behaviour of Wnt/ ‐catenin and Wnt/ Ca 2+ signalling pathways in arrhythmogenic right ventricular cardiomyopathy

Cited by 3 publications

References 48 publications

Static Analysis of Dengue Biological Regulatory Network’s

Static Analysis of Dengue Biological Regulatory Network’s

Targeting NAD+: is it a common strategy to delay heart aging?

A Static Analysis ofWnt/β-Catenin andWnt/Ca2+Biological Regulatory Networks for ARVC Using Automata Network Model

Contact Info

Product

Resources

About

Petri Net modelling approach for analysing the behaviour of Wnt/ ‐catenin and Wnt/ Ca ²⁺ signalling pathways in arrhythmogenic right ventricular cardiomyopathy

A Static Analysis ofWnt/β-Catenin andWnt/Ca²⁺Biological Regulatory Networks for ARVC Using Automata Network Model