No abstract

No abstract

In the past few years, e-learning is emerging as a global platform in the continuation of studies. E-learning has revolutionized the entire education system by providing flexibility and easy access to lectures anytime and anywhere, especially during covid-19 pandemic after which face-to-face learning was no longer possible. Although people were aware about e-learning and its usage but it got more prominent after COVID-19 pandemic. So, e-learning became a necessity for continuing education. This present study attempts to analyze the difficulties, benefits, and drawbacks of both educators and students by implementing these technologies as well as alternative solutions. This study discusses numerous prospects made possible by the COVID-19 pandemic and emphasizes the requirement for developing suitable methods to handle such an unanticipated crisis in the future. The problems faced by learners were a poor internet connection, a lack of electricity, a lack of interest, and a lack of desire. This study also suggests the government take the lead in assisting students who have limited access to the internet and technology, which are essential for participation in online classes, while also encouraging students to participate more actively in e-learning, particularly in context of the serious pandemic. To this purpose, various suggestions have been offered that could help academic institutions overcome these challenges and preserve academic quality during turbulent times.

Background and Objective: Curcumin (Cur) and piperine (Pip) are very well-known phytochemicals that claimed to have many health benefits and have been widely used in foods and traditional medicines. This study investigated the therapeutic efficacy of these compounds to treat Alzheimer’s disease (AD). However, poor oral bioavailability and permeability of curcumin are a major challenge for formulation scientists. In this research study, the researcher tried to enhance the bioavailability & permeability of curcumin by a nanotechnological approach. Materials and Methods In this research study, we developed a Cur-Pip-loaded SNEDDS in various oils. Optimized formulation NF3 was subjected to evaluate its therapeutic effectiveness on AD animal model in comparison with untreated AD model and treated group (by market formulation donepezil). Results On the basis of characterization results it is confirmed that NF3 formulation is the best formulation. The optimized formulation shows a significant dose-dependent manner therapeutic effect on AD-induced model Conclusion Novel formulation Cur-Pip Solid-SNEDDS was successfully developed and optimized. It’s expected developed S-SNEDDS can be a potential, safe and effective carrier for the oral delivery of curcumin to the brain. This research article first reported the bio-active S-SNEDDS of Cur-Pip effect on Alzheimer's.

Data integrity is an important current issue for regulators around the world. During inspections a multitude of problems being found by the pharmaceutical regulatory agency because poor practices develop the substandard product for patients. Collection of various types of information and results collectively made in the form of data. This data becomes one of the most valuable assets of any organization but without integrity, this data is not much useful. Accuracy and original data increase the chances of stability and performance of an organization.

Background and Objective:Curcumin (Cur) and piperine (Pip) are very well-known phytochemicals that claimed to have many health bene ts and have been widely used in foods and traditional medicines. This study investigated the therapeutic e cacy of these compounds to treat Alzheimer's disease (AD). However, poor oral bioavailability and permeability of curcumin are a major challenge for formulation scientists. In this research study, the researcher tried to enhance the bioavailability & permeability of curcumin by a nanotechnological approach. Materials and MethodsIn this research study, we developed a Cur-Pip-loaded SNEDDS in various oils. Optimized formulation NF3 was subjected to evaluate its therapeutic effectiveness on AD animal model in comparison with untreated AD model and treated group (by market formulation donepezil). ResultsOn the basis of characterization results it is con rmed that NF3 formulation is the best formulation. The optimized formulation shows a signi cant dose-dependent manner therapeutic effect on AD-induced model ConclusionNovel formulation Cur-Pip Solid-SNEDDS was successfully developed and optimized. It's expected developed S-SNEDDS can be a potential, safe and effective carrier for the oral delivery of curcumin to the brain. This research article rst reported the bio-active S-SNEDDS of Cur-Pip effect on Alzheimer's.

Recently it has been growing interest in investing solid state transition forms prepared by different technique. The majority of drugs are administered in solids form. Among all newly discovered chemical entities about 40% drugs are lipophillic and fail to reach market due to their poor aqueous solubility. Problem of solubility is a major challenge for formulation scientist, which can be resolved by different technological approaches. Simvastatin belong to class of antihyperlipidemic drugs having very low solubility and falls in category II Class of BCS. Polymorphism and solid state transitions change the solid-state property which is significantly influence the performance of the final product such as solubility, Melting Point, Dissolution Rate and flow property. Optimization process like RCM and CCD design was used to study the effect of variables such as solubility and melting point for quality determination of formulation. Solvent evaporation method is used in this study to prepare new transition form. This technique has more advantages and it is preferred method over others such as spray drying, sonication and homogenization. Through the characterized analysis (SEM, XRD, ATR, DSC, Solublity and melting point) of optimised form, given reliably confirmation data that the new solid state transition forms is amorphous form. It is more soluble than crystalline form.

No abstract