Pethidine versus tramadol for pain relief during labor

Keskin, Halit; Keskin, Ercan; Avşar, Ayşe Filiz; Tabuk, M.; Çağlar, Gamze Sinem

doi:10.1016/s0020-7292(03)00047-x

Cited by 45 publications

(43 citation statements)

References 2 publications

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“…8,17,19 The incidence of respiratory depression in the neonates was more in group I (Tramadol) i.e. 3(6.0%) in comparison to group II (Entonox) i.e.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of effectiveness of intermittent inhalational entonox in comparison with opioid tramadol for labour analgesia

Kumar¹,

Chandel

2017

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONGiving birth is a painful process. Any intervention that leads to improvement in pain relief is worthy of investigation 1 . Opioid as well as epidural analgesia is effective means for pain relief in labour, notwithstanding their shortcomings. Data regarding Entonox (50% Nitrous Oxide and 50% Oxygen mixture) for labour analgesia is not available in current Indian literature. Use of Entonox offers many apparent advantages over the ABSTRACT Background:Childbirth is an emotion-filled event and the mother needs to bond with her newborn baby as early as possible. Any intervention that leads to improvement in pain relief is worthy of investigation. Entonox, opioids as well as epidural analgesia are effective means for pain relief in labour, notwithstanding their shortcomings. The objectives of study are to compare the effectiveness of intermittent inhalational Entonox for labour analgesia with intramuscular opioid (Tramadol) and to compare the effects of Entonox and Tramadol as labour analgesia on the maternal and fetal outcome of labour. Methods:The study was a prospective randomized, comparative study of two established techniques of labour analgesia. The study was carried out in 100 subjects. These subjects are divided into two groups. Group A -Tramadol Group: 50 women in active labour who received 100 mg tramadol intramuscularly with repeat dose of 50mg tramadol 4 hourly. Group B -Entonox Group: 50 women in active labour who received entonox for labour analgesia. Results:The mean VAS (visual analogue score) i.e. the pain score in group I (Tramadol) was 4.58±1.54 and Group II (Entonox) was 4.02±1.99 which is significantly low when compared to Group I (Tramadol) p<0.001. Study also showed that both the analgesics Entonox as well as Tramadol does not cause any significant change when compared for duration of labor. The rate of instrumental assisted vaginal deliveries and normal vaginal deliveries were almost equal in both the groups. In our study, the mean overall satisfaction level of the parturients in group II (Entonox) at 1 hr post delivery was (5.06±1.42) and 24 hr post delivery was (6.64±1.66) which was more when compared with tramadol group. The difference was statistically significant (p value was <0.001). This indicates that overall satisfaction level of the parturients is more with the use of Entonox when compared with Tramadol. Conclusions: Therefore, it is concluded that intermittent inhalational Entonox provides better labour analgesia then intramuscular opioid Tramadol.

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“…8,17,19 The incidence of respiratory depression in the neonates was more in group I (Tramadol) i.e. 3(6.0%) in comparison to group II (Entonox) i.e.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of effectiveness of intermittent inhalational entonox in comparison with opioid tramadol for labour analgesia

Kumar¹,

Chandel

2017

Int J Reprod Contracept Obstet Gynecol

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“…[23][24][25][26][27][28][29] The number of participants who were given 50 mg of pethidine was 437, representing $ 26% of the total; this reflects the preference for researches employing more than 50 mg of pethidine, especially before 2006. Ideally, we need a study comparing pethidine at 2 doses: 50 mg and > 50 mg, with the same number of participants in each group.…”

Section: Discussionmentioning

confidence: 99%

Is Pethidine Safe during Labor? Systematic Review

Nunes

Colares

Montenegro

2017

Rev Bras Ginecol Obstet

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Purpose To verify if pethidine is safe for the conceptus when used during labor. Methods Systematic review in the Capes Periodicals/PubMed and MEDLINE/Virtual Health Library (BVS, in the Portuguese acronym) databases. Results A total of 17 studies published from January 1st, 2000, to September 2nd, 2016, with a total of 1,688 participants involved were included in the present review. There was no record of conceptus vitality decrease associated with low doses of pethidine being administered to mothers during labor. Conclusions Intramuscular (IM) or intravenous (IV) pethidine at low doses, of up to 50 mg, is safe to administer during labor.

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“…Consequently, adequate analgesia is essential in obstetrics. (10) Because of the lower incidence of side effects, and analgesic activity comparable to pethidine, tramadol has been recommended for obstetrical analgesia. (6,11) (13) The exposure of the neonate to M1, however, is hard to predict as it also depends on the time interval between drug administration and delivery of the child.…”

Section: Discussionmentioning

confidence: 99%

Probable association of neonatal death with the use of tramadol to treat labour pain

2012

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Pethidine versus tramadol for pain relief during labor

Abstract: Pethidine seems to be a better alternative than tramadol in obstetric analgesia because of its superiority in analgesic efficacy and low incidence of maternal side effects.

Cited by 45 publications

References 2 publications

Evaluation of effectiveness of intermittent inhalational entonox in comparison with opioid tramadol for labour analgesia

Evaluation of effectiveness of intermittent inhalational entonox in comparison with opioid tramadol for labour analgesia

Is Pethidine Safe during Labor? Systematic Review

Probable association of neonatal death with the use of tramadol to treat labour pain

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