Pethidine compared with meptazinol during labour

Abstract

Summary

Parenteral opioids for maternal pain management in labour

“…IM meptazinol versus IM pethidine (eight studies) (De Boer 1987; Jackson 1983; Morrison 1987; Nel 1981; Nicholas 1982; Osler 1987; Sheikh 1986; Wheble 1988). (In the studies by De Boer 1987 and Jackson 1983, women in both study groups also received add-on drugs.…”

“…Four studies described using numbered opaque sealed envelopes to conceal allocation (Giannina 1995; Khooshideh 2009; Tsui 2004; Volikas 2001). Seventeen studies described using identical coded drug boxes (although it may not have been clear who had access to the code or when the code was broken) (Atkinson 1994; Borglin 1971; Campbell 1961; Douma 2010; Fairlie 1999; Gillam 1958; Grant 1970; Lardizabal 1999; Levy 1971; Maduska 1978; Moore 1970; Morley-Forster 2000; Morrison 1987; Olofsson 1996; Olson 1964; Sheikh 1986; Wilson 1986). In the remaining studies it was not clear what steps were taken to conceal allocation at the point of randomisation.…”

“…One study (Morrison 1987) involving 801 women showed no evidence of a difference between meptazinol 100 mg to 150 mg compared with pethidine 100 mg to 150 mg for assessment of analgesic effect measured at three to five days postpartum (RR 1.01, 95% CI 0.91 to 1.12) (Analysis 2.1). In this study, more than half of the women receiving either of these opioids reported that they received no or poor relief despite the fact that women in both groups could also receive an additional dose of study drug, epidural or nitrous oxide as required.…”

Comparative Study on Efficacy of Ketorolac and Pethidine for Postoperative Pain Management

“…Among them 27 (45%) were males and 33 (55%) were females. They underwent various surgical procedures such as, appendectomy (16), cholecystectomy (14), laparotomy (13), tonsillectomy (9) and others (8). The analgesic efficacy (VAS score) and sedation score of ketorolac and pethidine were compared by administering these drugs postoperatively as (ketorolac, 30 patients) and (pethidine, 30 patients).…”

Intravenous Meperidine Infusion for Obstetric Analgesia

“…Generally, studies that have compared the effects of various intramuscular analgesics have recognized the unsatisfactory nature of IM administration for women in labor (Frank et al, 1987;Morrison, Dutton, Howie, & Gilmour, 1987;Wilson, McClean, Moore, & Dundee, 1986). Intermittent IV analgesia, commonly associated with a patient-controlled analgesia (PCA) for relief of pain, has been reported more favorably in the literature.…”