Petalonia improves glucose homeostasis in streptozotocin-induced diabetic mice

Kang, Seong-Il; Jin, Young-Jun; Ko, Hee-Chul; Choi, Sangdun; Hwang, Joon-Ho; Whang, Ilson; Kim, Moo-Han; Shin, Hye-Sun; Jeong, Hyung-Bok; Kim, Se-Jae

doi:10.1016/j.bbrc.2008.06.015

Cited by 31 publications

(21 citation statements)

References 23 publications

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“…Recently, we demonstrated that an ethanolic extract of P. binghamiae (PBE) exerts an adipogenic effect in 3T3-L1 cells and an anti-diabetic effect in streptozotocin-induced diabetic mice [22]. However, this study revealed that the water-soluble extract of P. binghamiae (PBEE) exerts an anti-adipogenic effect in 3T3-L1 cells.…”

Section: Discussionmentioning

confidence: 87%

“…In this regard, we have evaluated the potential of several extracts of the edible seaweed P. binghamiae in vitro using murine 3T3-L1 preadipocytes and in vivo using animal models [22]. In this study, we found that a water-soluble P. binghamiae extract, designated PBEE, dose dependently decreased the levels of triglycerides, PPARγ1 and 2, C/EBPα and aP2 in differentiating 3T3-L1 preadipocytes.…”

Section: Discussionmentioning

confidence: 93%

“…Galactosyldiacylglycerol [20] and fucoxanthin-related compounds [21] isolated from P. binghamiae inhibit mammalian DNA polymerase α and exert suppressive properties on adipocyte differentiation in 3T3-L1 cells, respectively. Moreover, we previously demonstrated that an ethanolic extract of P. binghamiae exerts an adipogenic effect in 3T3-L1 cells by acting as a mimetic for insulin, and that it exerts an antidiabetic effect in a streptozotocin-induced diabetic mice model [22]. However, the other potentially beneficial properties of P. binghamiae have not been studied.…”

Section: Introductionmentioning

confidence: 97%

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A water-soluble extract of Petalonia binghamiae inhibits the expression of adipogenic regulators in 3T3-L1 preadipocytes and reduces adiposity and weight gain in rats fed a high-fat diet

Kang

Kim

Shin

et al. 2010

The Journal of Nutritional Biochemistry

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 97%

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A water-soluble extract of Petalonia binghamiae inhibits the expression of adipogenic regulators in 3T3-L1 preadipocytes and reduces adiposity and weight gain in rats fed a high-fat diet

Kang

Kim

Shin

et al. 2010

The Journal of Nutritional Biochemistry

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“…There are also a few trials with seaweeds or seaweed preparations in humans investigating effects on blood pressure [5,6], appetite [7,8], inflammation [9], and insulin response [10]. These health effects may originate from a variety of seaweed compounds, such as soluble fiber and carotenoids [6,[11][12][13][14][15]. Only one study has so far shown which compounds can be used as biomarkers of seaweed intake in overweight or obese subjects.…”

Section: Introductionmentioning

confidence: 99%

Biomarkers of seaweed intake

Dragsted

2019

Genes Nutr

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Seaweeds are marine macroalgae, some of which are edible. They are rich in specific dietary fibers and also contain other characteristic biological constituents. Biological activities have been investigated mainly in animal studies, while very few results are available from human studies. Biomarkers of food intake (BFIs) specific to seaweed could play an important role as objective measurements in observational studies and dietary intervention studies. Thus, the health effects of seaweeds can be explored and understood by discovering and applying BFIs. This review summarizes studies to identify candidate BFIs of seaweed intake. These BFIs are evaluated by a structured validation scheme. Hydroxytrifuhalol A, 7-hydroxyeckol, CO -C dimer of phloroglucinol, diphloroethol, fucophloroethol, dioxinodehydroeckol, and/or their glucuronides or sulfate esters which all belong to the phlorotannins are considered candidate biomarkers for brown seaweed. Fucoxanthinol, the main metabolite of fucoxanthin, is also regarded as a candidate biomarker for brown seaweed. Further validation will be needed due to the very limited number of human studies. Further studies are also needed to identify additional candidate biomarkers, relevant specifically for the red and green seaweeds, for which no candidate biomarkers emerged from the literature search. Reliable BFIs should also ideally be found for the whole seaweed food group.

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“…Chlorella and Petalonia exhibited antidiabetic effects via both insulin-like and insulin-sensitizing behavior on in vitro tests (Cherng & Shih, 2006;Kang et al, 2008). The ethanolic extract of Ascophyllum nodosum inhibited rat-intestinal a-glucosidase, with an IC 50 value of 77 mg/ml and stimulated the reduction in liver glycogen levels in diabetic mice (Zhang et al, 2007).…”

Section: A-glucosidase and A-amylase Inhibitory Activitymentioning

confidence: 99%

New insights into seaweed polyphenols on glucose homeostasis

Murugan

Karim

Yusoff

et al. 2015

Pharmaceutical Biology

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Context: Polyphenol-rich marine macroalgae are gaining dietary importance due to their influence over diabetes mellitus and the role as a vital source of high-value nutraceuticals. Their assorted beneficial effects on human health include competitive inhibition of digestive enzymes, varying the activity of hepatic glucose-metabolizing enzymes, lowering the plasma glucose levels, and lipid peroxidation, delaying the aging process. Objective: In this paper, we review the health beneficial effects of polyphenols and phlorotannins from brown seaweeds with special emphasis on their inhibitory effects on carbohydrate-metabolizing enzymes. Methods: A survey of literature from databases such as Sciencedirect, Scopus, Pubmed, Springerlink, and Google Scholar from the year 1973 to 2013 was done to bring together the information relating to drug discovery from brown seaweeds as a source for diabetes treatment. Results: Over the past two decades, 20 different bioactive polyphenols/phlorotannins have been isolated and studied from 10 different brown algae. Discussion of the positive effect on the inhibition of enzymes metabolizing carbohydrates in both in vitro and in vivo experiments are included. Conclusion: Despite the recent advancements in isolating bioactive compounds from seaweeds with potential health benefit or pharmaceutical behavior, studies on the polyphenol effectiveness on glucose homeostasis in human beings are very few in response to their functional characterization. Added research in this area is required to confirm the close connection of polyphenol rich seaweed-based diet consumption with glucose homeostasis and the exciting possibility of prescribing polyphenols to treat the diabetes pandemic.

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Petalonia improves glucose homeostasis in streptozotocin-induced diabetic mice

Cited by 31 publications

References 23 publications

A water-soluble extract of Petalonia binghamiae inhibits the expression of adipogenic regulators in 3T3-L1 preadipocytes and reduces adiposity and weight gain in rats fed a high-fat diet

A water-soluble extract of Petalonia binghamiae inhibits the expression of adipogenic regulators in 3T3-L1 preadipocytes and reduces adiposity and weight gain in rats fed a high-fat diet

Biomarkers of seaweed intake

New insights into seaweed polyphenols on glucose homeostasis

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