PET-MRI: a review of challenges and solutions in the development of integrated multimodality imaging

Vandenberghe, Stefaan; Marsden, Paul

doi:10.1088/0031-9155/60/4/r115

Cited by 223 publications

(202 citation statements)

References 111 publications

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“…However, the physical combination of PET and MR represents a major technological challenge [45][46][47][48]. Conventional PET systems use PMTs to detect the scintillation light.…”

Section: Pet/mrmentioning

confidence: 99%

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Hybrid Imaging: Instrumentation and Data Processing

et al. 2018

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State-of-the-art patient management frequently requires the use of non-invasive imaging methods to assess the anatomy, function or molecular-biological conditions of patients or study subjects. Such imaging methods can be singular, providing either anatomical or molecular information, or they can be combined, thus, providing "anato-metabolic" information. Hybrid imaging denotes image acquisitions on systems that physically combine complementary imaging modalities for an improved diagnostic accuracy and confidence as well as for increased patient comfort. The physical combination of formerly independent imaging modalities was driven by leading innovators in the field of clinical research and benefited from technological advances that permitted the operation of PET and MR in close physical proximity, for example. This review covers milestones of the development of various hybrid imaging systems for use in clinical practice and small-animal research. Special attention is given to technological advances that helped the adoption of hybrid imaging, as well as to introducing methodological concepts that benefit from the availability of complementary anatomical and biological information, such as new types of image reconstruction and data correction schemes. The ultimate goal of hybrid imaging is to provide useful, complementary and quantitative information during patient work-up. Hybrid imaging also opens the door to multi-parametric assessment of diseases, which will help us better understand the causes of various diseases that currently contribute to a large fraction of healthcare costs.

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“…However, the physical combination of PET and MR represents a major technological challenge [45][46][47][48]. Conventional PET systems use PMTs to detect the scintillation light.…”

Section: Pet/mrmentioning

confidence: 99%

“…Table 2 summarizes the main system specifications. A complete description of all the available preclinical hybrid systems is outside the focus of this review paper, please see [46,[61][62][63][64][65] for details.…”

Section: Preclinical Hybrid Imagingmentioning

confidence: 99%

Hybrid Imaging: Instrumentation and Data Processing

et al. 2018

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“…PET-MR orthogonally merges the outstanding resolution and soft-tissue contrast of MRI with the functional capability and sensitivity of PET. Compared with PET-CT, PET-MR affords a significant reduction in patient exposure to ionising radiation in addition to generally better intrinsic soft-tissue contrast [57][58][59] . PET-MR delivers additional opportunities for multiplexing through the use of dual-modality radioisotope/MR active molecular or nanoparticle-based probes, and the option of simultaneous T1-/T2-/diffusion-weighted data acquisition 33,60 .…”

Section: Pet-mrmentioning

confidence: 99%

Multiplexed imaging for diagnosis and therapy

et al. 2017

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Complex molecular and metabolic phenotypes depict cancers as a constellation of different diseases with common themes. Precision imaging of such phenotypes requires flexible and tuneable modalities capable of identifying phenotypic fingerprints by using a restricted number of parameters whilst ensuring sensitivity to dynamic biological regulation. Common phenotypes can be detected by in vivo imaging technologies, and effectively define the emerging standards for disease classification and patient stratification in radiology. However, for the imaging data to accurately represent a complex fingerprint, the individual imaging parameters need to be measured and analysed in relation to their wider spatial and molecular context. In this respect, targeted palettes of molecular imaging probes facilitate the detection of heterogeneity in oncogene-driven alterations and their response to treatment, and lead to the expansion of rational-design elements for the combination of imaging experiments. In this Review, we evaluate criteria for conducting multiplexed imaging, and discuss its opportunities for improving patient diagnosis and the monitoring of therapy.

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“…Recent advancements have overcome many technical challenges, including interference between imaging modalities, to make integrated PET-MR systems possible ( Figure 1) (32,33). The main challenges revolve around (36) has made truly simultaneous PET-MRI possible.…”

Section: Pet-mri Systems and Technical Considerationsmentioning

confidence: 99%

Potential of PET-MRI for imaging of non-oncologic musculoskeletal disease

Kogan

Fan

Gold

2016

Quant. Imaging Med. Surg.

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Early detection of musculoskeletal disease leads to improved therapies and patient outcomes, and would benefit greatly from imaging at the cellular and molecular level. As it becomes clear that assessment of multiple tissues and functional processes are often necessary to study the complex pathogenesis of musculoskeletal disorders, the role of multi-modality molecular imaging becomes increasingly important.New positron emission tomography-magnetic resonance imaging (PET-MRI) systems offer to combine high-resolution MRI with simultaneous molecular information from PET to study the multifaceted processes involved in numerous musculoskeletal disorders. In this article, we aim to outline the potential clinical utility of hybrid PET-MRI to these non-oncologic musculoskeletal diseases. We summarize current applications of PET molecular imaging in osteoarthritis (OA), rheumatoid arthritis (RA), metabolic bone diseases and neuropathic peripheral pain. Advanced MRI approaches that reveal biochemical and functional information offer complementary assessment in soft tissues. Additionally, we discuss technical considerations for hybrid PET-MR imaging including MR attenuation correction, workflow, radiation dose, and quantification.

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PET-MRI: a review of challenges and solutions in the development of integrated multimodality imaging

Cited by 223 publications

References 111 publications

Hybrid Imaging: Instrumentation and Data Processing

Hybrid Imaging: Instrumentation and Data Processing

Multiplexed imaging for diagnosis and therapy

Potential of PET-MRI for imaging of non-oncologic musculoskeletal disease

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