2002
DOI: 10.1007/s00259-002-0897-z
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PET imaging of human cardiac opioid receptors

Abstract: The presence of opioid peptides and receptors and their role in the regulation of cardiovascular function has been previously demonstrated in the mammalian heart. The aim of this study was to image micro and delta opioid receptors in the human heart using positron emission tomography (PET). Five subjects (three females, two males, 65+/-8 years old) underwent PET scanning of the chest with [(11)C]carfentanil ([(11)C]CFN) and [(11)C]- N-methyl-naltrindole ([(11)C]MeNTI) and the images were analyzed for evidence … Show more

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Cited by 43 publications
(29 citation statements)
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“…In experimental models of ischemia reperfusion injury, morphine inhibits the mitochondrial permeability transition pore24 opening through μ and κ myocardial opioid receptors,25, 26 and induced a significant cardioprotective effect 27. Morphine also stimulates the reperfusion injury salvage kinase pathway 24.…”
Section: Discussionmentioning
confidence: 99%
“…In experimental models of ischemia reperfusion injury, morphine inhibits the mitochondrial permeability transition pore24 opening through μ and κ myocardial opioid receptors,25, 26 and induced a significant cardioprotective effect 27. Morphine also stimulates the reperfusion injury salvage kinase pathway 24.…”
Section: Discussionmentioning
confidence: 99%
“…Although ␦-opioid agonists exert potent cardioprotection, it is unclear which type of cardiac cells actually express ␦-opioid receptor (DOR). Despite the receptor-binding study of DOR (11,27,33) and its gene expression in human and animal hearts (2, 28), no clear immunohistochemical evidence has demonstrated in situ DOR expression in cardiac myocytes. The intrinsic cardiac adrenergic (ICA) cell is a neuroendocrine cell that expresses genes and enzyme proteins for epinephrine biosynthesis (5, 9, 10).…”
mentioning
confidence: 99%
“…At present, there is an increasing demand of radioligands for in vivo imaging studies of peripheral opioid receptors to help assess the roles they may play in cancer, cardiovascular disease, gastrointestinal disorders, and pain relief. 24 The feasibility of imaging δ-opioid receptors in normal human heart, 25 , fluorescamine (Hoffman-La Roche) and chlorine spray reagents. Melting points were determined on a Kofler apparatus and are uncorrected.…”
Section: Discussionmentioning
confidence: 99%