PET imaging of brain astrocytoma with 1-11C-acetate

Abstract

ACE appears to be a promising tracer for use in the detection of primary astrocytomas, but is of limited value in the differentiation of high- and low-grade astrocytomas. ACE is complementary to FDG for the diagnosis and characterisation of astrocytoma.

Interaction of brain fatty acid-binding protein with the polyunsaturated fatty acid environment as a potential determinant of poor prognosis in malignant glioma

“…Studies are underway to develop 18 F-fluoro tracers, as 18 F has a half life of 110 min compared to 20 min for 11 C, thus allowing the capture of higher resolution images. While AA and DHA-based radiotracers have not yet been used to image brain tumors, PET imaging using 1-11 C-acetate and 2-18 F-fluoro-2-deoxy-D-glucose tracers have shown promise for the detection of primary astrocytomas in humans [123]. Furthermore, standardized uptake values that correlated with astrocytoma histological grade were observed with 2-18 F-fluoro-2-deoxy-D-glucose [123].…”

“…While AA and DHA-based radiotracers have not yet been used to image brain tumors, PET imaging using 1-11 C-acetate and 2-18 F-fluoro-2-deoxy-D-glucose tracers have shown promise for the detection of primary astrocytomas in humans [123]. Furthermore, standardized uptake values that correlated with astrocytoma histological grade were observed with 2-18 F-fluoro-2-deoxy-D-glucose [123]. We propose that the altered uptake/ turnover of AA and DHA in malignant glioma compared to normal brain tissue could be exploited for the imaging and grading of astrocytomas.…”

Imaging Cellular Metabolism

“…[ 11 C]Acetate has recently been used to detect increased glial tumor metabolism (Liu et al, 2006;Tsuchida et al, 2008). 2-18 F-fluoroacetate has been successful in detecting glioblastoma in a mouse model system (Marik et al, 2009).…”

1-11C-Acetate Versus 18F-FDG PET in Detection of Meningioma and Monitoring the Effect of γ-Knife Radiosurgery

“…Dienel et al reported that 2-14 C-acetate preferentially labeled glial tumors grown in rat brain and human glioma and meningioma explants (23). Our previous study showed that 1-11 C-acetate detected astrocytomas better than did 18 F-FDG (22). No clinical studies have so far compared 1-11 C-acetate and 18 F-FDG PET in the diagnosis of meningioma.…”

“…1-11 C-acetate has been used for the detection of renal carcinoma (18), nasopharyngeal carcinoma (19), prostate cancer (20), hepatoma (21), and astrocytoma (22). The possible mechanisms of tumor uptake of 1-11 C-acetate include impaired tricarboxylic acid cycle activity or the distribution of tracer among the various intermediate metabolites (19) or incorporation of tracer in the tumor through the anabolic pathways in fatty acid and sterol synthesis (20).…”