PET-CT radiomics by integrating primary tumor and peritumoral areas predicts E-cadherin expression and correlates with pelvic lymph node metastasis in early-stage cervical cancer

Li, Xiaoran; Jin, Junjie; Yu, Yang; Wang, Xinghao; Guo, Yan; Sun, Hongzan

doi:10.1007/s00330-021-07690-7

Cited by 27 publications

(15 citation statements)

References 37 publications

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“…Current translational research efforts in breast oncology are extensive, however studies focusing on ILC remain sparse, particularly in relation to radiogenomics within ILC. Recently, Li et al have been successful in their radiomic appraisal of E-Cadherin expression in primary cancer and peritumoral tissue in cervical cancers [71], and advocate similar analyses in determining ILC histopathological subtyping in the breast cancer paradigm.…”

Section: Discussionmentioning

confidence: 99%

Radiomic differentiation of breast cancer molecular subtypes using pre-operative breast imaging – A systematic review and meta-analysis

Davey

Boland

et al. 2021

European Journal of Radiology

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Breast cancer has four distinct molecular subtypes which are discriminated using gene expression profiling following biopsy. Radiogenomics is an emerging field which utilises diagnostic imaging to reveal genomic properties of disease. We aimed to perform a systematic review of the current literature to evaluate the value radiomics in differentiating breast cancers into their molecular subtypes using diagnostic imaging. Methods: A systematic review was performed as per PRISMA guidelines. Studies assessing radiomic tumour analysis in differentiating breast cancer molecular subtypes were included. Quality was assessed using the radiomics quality score (RQS). Diagnostic sensitivity and specificity of radiomic analyses were included for metaanalysis; Study specific sensitivity and specificity were retrieved and summary ROC analysis were performed to compile pooled sensitivities and specificities. Results: Forty-one studies were included. Overall, there were 10,090 female patients (mean age of 47.6 ± 11.7 years, range: 21 -93) and molecular subtype was reported in 7,693 of cases, with Luminal A (LABC), Luminal B (LBBC), Human Epidermal Growth Factor Receptor-2 overexpressing (HER2+), and Triple Negative (TNBC) breast cancers representing 51.3%, 19.9%, 12.3% and 16.3% of tumour respectively. Seven studies provided radiomic analysis to determine molecular subtypes using mammography to differentiate TNBC vs.

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Section: Discussionmentioning

confidence: 99%

Radiomic differentiation of breast cancer molecular subtypes using pre-operative breast imaging – A systematic review and meta-analysis

Davey

Boland

et al. 2021

European Journal of Radiology

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“…A total of 22 publications on cervical cancer were retrieved; 19 of them exclusively dealt with cervical cancer [ 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 ], while the remaining 3 described multiple types of cancers, including cervical cancer [ 92 , 93 , 94 ]. All of the studies were retrospective and employed 18F-FDG.…”

Section: Resultsmentioning

confidence: 99%

Radiomics in Oncological PET Imaging: A Systematic Review—Part 2, Infradiaphragmatic Cancers, Blood Malignancies, Melanoma and Musculoskeletal Cancers

et al. 2022

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The objective of this review was to summarize published radiomics studies dealing with infradiaphragmatic cancers, blood malignancies, melanoma, and musculoskeletal cancers, and assess their quality. PubMed database was searched from January 1990 to February 2022 for articles performing radiomics on PET imaging of at least 1 specified tumor type. Exclusion criteria includd: non-oncological studies; supradiaphragmatic tumors; reviews, comments, cases reports; phantom or animal studies; technical articles without a clinically oriented question; studies including <30 patients in the training cohort. The review database contained PMID, first author, year of publication, cancer type, number of patients, study design, independent validation cohort and objective. This database was completed twice by the same person; discrepant results were resolved by a third reading of the articles. A total of 162 studies met inclusion criteria; 61 (37.7%) studies included >100 patients, 13 (8.0%) were prospective and 61 (37.7%) used an independent validation set. The most represented cancers were esophagus, lymphoma, and cervical cancer (n = 24, n = 24 and n = 19 articles, respectively). Most studies focused on 18F-FDG, and prognostic and response to treatment objectives. Although radiomics and artificial intelligence are technically challenging, new contributions and guidelines help improving research quality over the years and pave the way toward personalized medicine.

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“…Studies on tumor cells have shown that the inhibition of E-cadherin protein levels and the increase of α-SMA protein levels promote the migration and invasion of tumor cells [22][23][24]. Therefore, it has been recognized that increasing the expression and functional activity of E-cadherin [25,26] and reducing the expression of α-SMA [27] can alleviate tumor progression. This concept has also been applied to attenuate HG-and streptozotocin (STZ)-induced EMT [28,29].…”

Section: Discussionmentioning

confidence: 99%

Tanshinone IIA attenuates high glucose-induced epithelial-to-mesenchymal transition in HK-2 cells through VDR/Wnt/β-catenin signaling pathway

Zeng

Bao

2021

Folia Histochem Cytobiol.

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PET-CT radiomics by integrating primary tumor and peritumoral areas predicts E-cadherin expression and correlates with pelvic lymph node metastasis in early-stage cervical cancer

Cited by 27 publications

References 37 publications

Radiomic differentiation of breast cancer molecular subtypes using pre-operative breast imaging – A systematic review and meta-analysis

Radiomic differentiation of breast cancer molecular subtypes using pre-operative breast imaging – A systematic review and meta-analysis

Radiomics in Oncological PET Imaging: A Systematic Review—Part 2, Infradiaphragmatic Cancers, Blood Malignancies, Melanoma and Musculoskeletal Cancers

Tanshinone IIA attenuates high glucose-induced epithelial-to-mesenchymal transition in HK-2 cells through VDR/Wnt/β-catenin signaling pathway

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