PET/CT in the Evaluation of Inflammatory Bowel Disease: Studies in Patients Before and After Treatment

Abstract

Appropriate FDG-PET determination decreases with successful treatment of inflammation in active IBD and correlates with symptom improvement.

18F-FDG as an inflammation biomarker for imaging dengue virus infection and treatment response

“…18 F-FDG has also been used to nonspecifically image sites of viral infection or inflammation, because its detection can be proportional to the glycolytic activity of the cells that trap it (24)(25)(26). In this preclinical study, we demonstrate the efficacy of 18 F-FDG-based PET combined with CT imaging ( 18 F-FDG-PET/CT) as a noninvasive imaging strategy for the sensitive detection of inflammatory disease foci in dengue-infected mice and for monitoring disease amelioration in response to treatment.…”

Translational 18F-FDG PET/CT Imaging to Monitor Lesion Activity in Intestinal Inflammation

“…In preliminary studies, 18 F-FDG PET has shown promising results for the assessment of inflammation in adult and pediatric patients with IBD (11,12). However, because of the limited knowledge regarding its implication for treatment decisions, the method is not routinely used for determining disease activity.…”

Role of 18F-fluorodeoxyglucose Positron Emission Tomography in the Monitoring of Inflammatory Activity in Crohnʼs Disease

“…Moreover good correlations between PET measures and endoscopic and histo-pathological reference standards have been shown [10][11][12]33 . However, no studies to date examined the utility of FDG-PET to monitor longitudinal changes in bowel inflammation in CD has only been examined in a small study of three patients 13 .…”

“…9/13 patients who completed PET scanning both at baseline and a median [range] of 12 [11][12][13][14][15][16][17][18] weeks after initiation of anti-TNF treatment had favourable clinical responses 27 (median [range] responder ΔHBI = 5 [3][4][5][6][7][8][9]; non-responder ΔHBI = 1[-1-2]), (Table 1). …”

“…More recent reports also have explored composite measures that additionally reflect signal volume 11,12 . The potential of FDG-PET to demonstrate changes in lesion activity over time was first suggested in a report which included 3 CD patients 13 . However, there have been no systematic prospective studies with defined scanning intervals to further investigate this.…”