PET/CT in Gynecologic Cancer: Present Applications and Future Prospects—A Clinician’s Perspective

Agarwal, Amit; Schink, Julian C.; Reiss, Ari; Löwenstein, Lior

doi:10.1016/j.cpet.2010.07.001

Cited by 9 publications

(8 citation statements)

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“…In the United States, however, CT, MRI, combined PET/CT, and surgical staging are often used to guide treatment options and design. [25][26][27][28][29] The earliest stages of cervical carcinoma may be asymptomatic or associated with a watery vaginal discharge and postcoital bleeding or intermittent spotting. Often these early symptoms are not recognized by the patient.…”

Section: Diagnosis and Workupmentioning

confidence: 99%

Cervical Cancer

Koh¹,

Greer²,

Abu‐Rustum³

et al. 2013

J Natl Compr Canc Netw

117

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These NCCN Clinical Practice Guidelines in Oncology for Cervical Cancer focus on early-stage disease, because it occurs more frequently in the United States. After careful clinical evaluation and staging, the primary treatment of early-stage cervical cancer is either surgery or radiotherapy. These guidelines include fertility-sparing and non-fertility-sparing treatment for those with early-stage disease, which is disease confined to the uterus. A new fertility-sparing algorithm was added for select patients with stage IA and IB1 disease..

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Section: Diagnosis and Workupmentioning

confidence: 99%

Cervical Cancer

Koh¹,

Greer²,

Abu‐Rustum³

et al. 2013

J Natl Compr Canc Netw

117

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“…18 F-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) is a molecular imaging technique, which can be used to evaluate tumor distribution and glucose metabolism in different kinds of cancers including gynecologic malignancy [10]. A few publications have explored the role of 18 F-FDG PET/CT quantitative parameters in epithelial ovarian cancer, usually lumping all histologic subtypes together [11][12][13][14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

The role of 18F-FDG PET/CT-based quantitative metabolic parameters in patients with ovarian clear cell carcinoma

Liu

Zhou

et al. 2020

CBM

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BACKGROUND: Ovarian clear cell carcinoma (CCC) is enriched in genes associated with glucose metabolism. OBJECTIVE: To evaluate the 18 F-FDG PET/CT-based metabolic variables and the correlations with clinicopathologic features in OCCC patients. METHODS: We measured quantitative parameters including maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV) and total lesion glycolysis (TLG). RESULTS: A total of 22 patients were included. PET/CT-based metabolic parameters were calculated for 20 patients because two had low glucose-uptake tumor. The median SUVmax was 7.25 (range 2.50-14.80). Spearman's correlation test revealed that the level of pre-operative serum cancer antigen 125 (CA 125) correlated significantly with MTV (P = 0.020) and TLG (P = 0.023). Interestingly, platinum-sensitive patients tended to have higher MTV/TLG though significance not achieved. On univariate analysis, the following four variables (stage, residual disease, platinum sensitivity and MTV50) were significant for both progression-free survival and overall survival. Besides, four metabolic parameters (MTV40, TLG40, TLG50 and TLG60) were significantly associated with patients' overall survival. Out of expectation, ovarian CCC patients with higher level of MTV/TLG tended to have better survival. CONCLUSIONS: 18 F-FDG PET/CT-based metabolic volumetric parameters might be predicators for survival in ovarian CCC patients. Cautions should be taken when interpreting the results due to the small sample size.

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“…Similar to many other malignancies, endometrial carcinoma has increased glycolysis rate which makes it a suitable target for 18-F-FDG PET imaging [31]. In the current study, we evaluated the accuracy of 18-F-FDG PET imaging for diagnosis of endometrial cancer recurrence by comprehensive search of the available literature.…”

Section: Discussionmentioning

confidence: 99%