PET‐CT and the detection of the asymptomatic recurrence or second primary lesions in the treated head and neck cancer patient

Dunsky, Katherine A.; Wehrmann, Daniel; Osman, Medhat; Thornberry, Brandon M.; Varvares, Mark A.

doi:10.1002/lary.23941

Cited by 39 publications

(35 citation statements)

References 13 publications

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“…4 Neck metastases are found in 65% to 83% of patients on initial evaluation, and many patients with clinically negative necks have occult disease. 5 For HPVpositive tonsillar carcinoma, a recent retrospective analysis by Sood et al 6 has shown little relationship between tumor stage and nodal metastasis, although there is some correlation between tumor stage and distant disease. 6 Distant metastases are found in 15% to 30% of patients, with a predilection for lung involvement, followed by those of liver and bone.…”

mentioning

confidence: 99%

Transoral Robotic Surgery in Oropharyngeal Carcinoma

Helman¹,

Schwedhelm²,

Kadakia³

et al. 2015

Archives of Pathology &Amp; Laboratory Medicine

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Context The incidence of oropharyngeal squamous cell carcinoma has increased during the past decade and is related primarily to the human papillomavirus. This change in etiology, from tobacco and alcohol to human papillomavirus, has resulted in improved survival for the disease. In the United States, open resection had largely been replaced by concurrent chemotherapy and/or radiotherapy by the early 2000s. The advent of transoral surgery has led to an increase in surgery as the primary treatment for both early- and advanced-stage oropharyngeal squamous cell carcinoma because it has potential advantages over open surgery and nonsurgical modalities. Objective To provide an overview of transoral robotic surgery for oropharyngeal squamous cell carcinoma and contrast it with other surgical and nonsurgical modalities. Data Sources Articles from 2000 to 2014 were accessioned on PubMed and reviewed for utility by the primary authors. Conclusions Transoral surgery has become more commonly used as a minimally invasive approach to treat oropharyngeal tumors. Other strategies, including radiation, chemotherapy with radiation, and open surgery, are still important treatment approaches. The treatment options for an individual patient rely on multiple factors, including the tumor location and size, features of the tumor, and patient comorbidities. The continued study of these techniques is important to match the patient with the most appropriate treatment.

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mentioning

confidence: 99%

Transoral Robotic Surgery in Oropharyngeal Carcinoma

Helman¹,

Schwedhelm²,

Kadakia³

et al. 2015

Archives of Pathology &Amp; Laboratory Medicine

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“…Most HNSCC recurrences occur within the first 2 years 2 and, thus, we believe that surveillance 18 F-FDG PET/CT beyond the first 2 years is of limited value, as also suggested in several previous reports. [15][16][17] This study had several limitations. First, a retrospective analysis was performed in a relatively small number of subjects who received different treatment.…”

Section: Discussionmentioning

confidence: 96%

“…16 For this reason, prospective controlled randomized studies using 18 F-FDG PET/CT to monitor patients with HNSCC are needed to clarify whether early detection of recurrent or second primary cancer by surveillance 18 F-FDG PET/CT in a treated patient without symptoms can lead to improved survival.…”

Section: E517mentioning

confidence: 99%

Detection of subclinical recurrence or second primary cancer using ¹⁸F‐FDG PET/CT in patients treated curatively for head and neck squamous cell carcinoma

et al. 2015

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“…The role of PET/CT in the assessment of post-treatment status has become more standardized, and there are new promising results from PET/MR [17][18][19][20][21]. CT perfusion of the head and neck has also shown some promising results in assesing the status of the head and neck area [22].…”

Section: Discussionmentioning

confidence: 99%

Dynamic Contrast-Enhanced MRI Parameters as Biomarkers in Assessing Head and Neck Lesions After Chemoradiotherapy Using a Wide-Bore 3 Tesla Scanner

Léránt

Sarkozy

Takácsi‐Nagy

et al. 2015

Pathol. Oncol. Res.

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Pilot studies have shown promising results in characterizing head and neck tumors (HNT) using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), differentiating between malignant and benign lesions and evaluating changes in response to chemoradiotherapy (CRT). Our aim was to find DCE-MRI parameters, biomarkers in evaluating the post-CRT status. Two hundred and five patients with head and neck lesions were examined with DCE-MRI sequences. The time intensity curves (TIC) were extracted and processed to acquire time-to-peak (TTP), relative maximum enhancement (RME), relative wash-out (RWO), and two new parameters attack and decay. These parameters were analyzed using univariate tests in SPSS (Statistical Package for the Social Sciences, version 17, SPSS Inc. Chicago, USA) to identify parameters that could be used to infer tumor malignancy and post-CRT changes. Multiple parameters of curve characteristics were significantly different between malignant tumors after CRT (MACRT) and changes caused by CRT. The best-performing biomarkers were the attack and the decay. We also found multiple significant (p < 0.05) parameters for both the benign and malignant status as well as pre- and post-CRT status. Our large cohort of data supports the increasing role of DCE-MRI in HNT differentiation, particularly for the assessment of post-CRT status along with accurate morphological imaging.

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PET‐CT and the detection of the asymptomatic recurrence or second primary lesions in the treated head and neck cancer patient

Abstract: PET-CT scanning is an effective tool for detecting asymptomatic disease in patients previously treated for head and neck cancer. Unfortunately, even with early detection of recurrent disease, the mortality rate remains high.

Cited by 39 publications

References 13 publications

Transoral Robotic Surgery in Oropharyngeal Carcinoma

Transoral Robotic Surgery in Oropharyngeal Carcinoma

Detection of subclinical recurrence or second primary cancer using ¹⁸F‐FDG PET/CT in patients treated curatively for head and neck squamous cell carcinoma

Dynamic Contrast-Enhanced MRI Parameters as Biomarkers in Assessing Head and Neck Lesions After Chemoradiotherapy Using a Wide-Bore 3 Tesla Scanner

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PET‐CT and the detection of the asymptomatic recurrence or second primary lesions in the treated head and neck cancer patient

Abstract: PET-CT scanning is an effective tool for detecting asymptomatic disease in patients previously treated for head and neck cancer. Unfortunately, even with early detection of recurrent disease, the mortality rate remains high.

Cited by 39 publications

References 13 publications

Transoral Robotic Surgery in Oropharyngeal Carcinoma

Transoral Robotic Surgery in Oropharyngeal Carcinoma

Detection of subclinical recurrence or second primary cancer using 18F‐FDG PET/CT in patients treated curatively for head and neck squamous cell carcinoma

Dynamic Contrast-Enhanced MRI Parameters as Biomarkers in Assessing Head and Neck Lesions After Chemoradiotherapy Using a Wide-Bore 3 Tesla Scanner

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Detection of subclinical recurrence or second primary cancer using ¹⁸F‐FDG PET/CT in patients treated curatively for head and neck squamous cell carcinoma