PET/CT and contrast-enhanced CT: making a difference in assessment and staging of patients with lymphoma

Zytoon, Ashraf Anas; Mohamed, Hala Hafez; Mostafa, Basma Adel Abd Elaziz; Houseni, Mohamed

doi:10.1186/s43055-020-00320-0

Cited by 8 publications

(13 citation statements)

References 24 publications

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“…The use of CECT in PET/CT assisted in improved characterization and anatomic localization of lesions, although contrast-enhanced pixel scan has the potential to cause focal artifacts in PET images, which is undesirable for tumor imaging [21].…”

Section: Discussionmentioning

confidence: 99%

Role of 18F-FDG PET/CT in evaluation of recently diagnosed breast cancer patients

Kamal

Sakr

et al. 2022

Egypt J Radiol Nucl Med

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Background Breast cancer is the most frequent malignant disease in women and usually affects people of all ages, races, socioeconomic classes, and geographic locations. Once breast cancer is diagnosed, tumor staging should be assessed precisely before treatment and prognosis could be determined. The purpose of this study was to determine the diagnostic usefulness of PET/CT in the initial assessment of patients with newly diagnosed breast cancer who were referred for tumor staging, pre-therapeutic or preoperative evaluation. Results In the examined 50 patients, PET/CT has higher sensitivity and accuracy compared to CT alone (reaching 100% for PET/CT and 96% for CT) in detecting malignant breast lesions, regional and distant nodal deposits as well as distant deposits, with subsequent upstaging in two patients. Conclusions 18F-FDG PET/CT is a single valuable technique that detects metastatic illness in newly diagnosed breast cancer patients in an efficient, accurate, and noninvasive manner, resulting in modification of the initial staging, which in turn reflected on the patients' therapeutic plans.

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Section: Discussionmentioning

confidence: 99%

Role of 18F-FDG PET/CT in evaluation of recently diagnosed breast cancer patients

Kamal

Sakr

et al. 2022

Egypt J Radiol Nucl Med

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“…e use of contrast enhancement has improved diagnosis worldwide. [1,5,6,[12][13][14][15][16] In Ghana, CECT is widely used to diagnose and manage various complaints including headaches as it facilitates a comprehensive diagnosis and timely and targeted intervention. [17] Radiographic examination of the head is an essential part of management of patients with various degrees of headache.…”

Section: Discussionmentioning

confidence: 99%

“…[10] e use of contrast enhancement has improved diagnosis and treatment worldwide. [1,5,6,[12][13][14][15][16] However, not much has been reported from developing countries regarding these innovations of CECT and headache investigations.…”

Section: Introductionmentioning

confidence: 99%

Contrast Medium Use in Computed Tomography for Patients Presenting with Headache: 4-year Retrospective Two-Center Study in Central and Western Regions of Ghana

Jimah

Sarkodie

Offei

et al. 2022

Radiology Research and Practice

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Background. Contrast medium (CM) administration during computed tomography (CT) enhances the accuracy in the detection and interpretation of abnormalities. Evidence from literature also validate the essence of CM in imaging studies. CT, by virtue of its ubiquity, ease of use, speed, and lower financial footprint, is usually the first investigation in cases of headache. Through a multicenter retrospective analysis, we compared findings of contrast-enhanced CT (CECT) to noncontrast-enhanced CT (NCECT) head examinations among patients presenting with headache. Methods. A multicenter retrospective analysis of four years’ CT head examination data at two radiology centers located in Central and Western Regions of Ghana were reviewed. Records of patients who presented with headache as principal complaint between January 2017 and December 2020 were reviewed. A total of 477 records of patients with headache were identified, retrieved and evaluated. A Chi-square test and Fisher exact test were used to compare the CECT and NCECT groups. Binary logistic regression analysis was computed to assess association between CECT and each CT findings. Statistical significance was considered at p < 0.05 with a 95% confidence interval. Results. A significant proportion of the patients was females (51.8% in CECT and 60% in NCECT). The NCECT group (40.06 ± 14.76 years) was relatively older than the CECT group (38.43 ± 17.64 years). There was a significant difference between the CECT and NCECT in terms of age ( p = 0.002 ) and facility CT was performed ( p < 0.0001 ). The rate of abnormalities was higher in CECT (43.5%, 166/382) compared NCECT (37.9%, 36/95). There was no significant association between CT head findings and contrast enhancement. Conclusion. CECT examination accounted for 5.6% increase in the detection of head abnormalities. Efforts required to establish local standard operation procedures (SOPs) for contrast medium use especially in CT head examinations. Further studies to improve the knowledge of agents, mechanism of action, and safety of contrast media used among practitioners in Ghana is recommended.

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“…The CTAC dose can be reduced from a range of 3.2 -8.3 mSv to 0.9 -3.2 mSv. This is especially beneficial for radiation-sensitive patients such as children, young adults and pregnant women [2] [27] [28] [29]. Another study conducted evaluated a new CT dose reduction method for PET/CT imaging, applying the "selective CT" technique for localization in follow-up studies of pediatric patients with Langerhans cell histiocytosis.…”

Section: Ct-based Attenuation Correction (Ac) Strategymentioning

confidence: 99%

Strategies to Improve CT Dose Optimization for Hybrid PET/CT Imaging

Yaseen¹,

Radzi²,

Almohiy³

et al. 2021

OJMI

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Background: To evaluate whether current dose reduction strategies for the CT component of hybrid Positron Emission Tomography-Computed Tomography (PET/CT) systems could reduce patient dose with maintaining adequate image quality for PET/CT studies. Materials and Methods: Literature survey was initially based on the selection of keywords and years of publication to identify potentially relevant articles, then the further search was conducted on the authors and references from these articles. The abstract of each article was first appraised to decide whether the content was relevant to this research question. The articles were classified into five groups: studies on dosimetry, studies on radiation-induced diseases, studies on dose reduction methods for CT-based attenuation correction (CTAC), studies on dose reduction methods for CT localization, and studies on reducing the need for a full-dose diagnostic CT in PET/CT imaging. 58 peer-reviewed articles were selected and appraised and 29 articles were used to compose this literature review. Results: The published nuclear medicine and medical physics literature were reviewed. CT dose contributed 47% -81% of the total effective dose of a standard PET/CT study and was associated with radiation-induced diseases. The dose reduction techniques were extracted and divided into three categories: reducing the CT dose for attenuation correction (AC) and localization, selectively localizing CT use, and reducing the need for a full-dose diagnostic CT. Conclusion: Three strategies have been demonstrated, with high potential for reducing patient dose while maintaining an adequate CT image quality, used for CTCA localization and diagnosis, respectively.

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PET/CT and contrast-enhanced CT: making a difference in assessment and staging of patients with lymphoma

Cited by 8 publications

References 24 publications

Role of 18F-FDG PET/CT in evaluation of recently diagnosed breast cancer patients

Role of 18F-FDG PET/CT in evaluation of recently diagnosed breast cancer patients

Contrast Medium Use in Computed Tomography for Patients Presenting with Headache: 4-year Retrospective Two-Center Study in Central and Western Regions of Ghana

Strategies to Improve CT Dose Optimization for Hybrid PET/CT Imaging

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