Pestiviruses infections at the wild and domestic ruminants interface in the French Southern Alps

Martin, C. J.; Duquesne, Véronique; Adam, Gilbert; Belleau, Eric; Gauthier, D.; Champion, Jean-Luc; Saegerman, Claude; Thiéry, Richard; Dubois, Éric

doi:10.1016/j.vetmic.2014.11.025

Cited by 21 publications

(29 citation statements)

References 29 publications

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“…There were also some highly significant subclades (pp = 1) among Pyrenean chamois sequences, clustering three geographical areas in Pyrenees: Eastern area (Freser-Setcases), Central area (Cadí, Cerdanya-Alt Urgell, Ariege) and Western area (Alt Pallars, Alta Ribagorça, Aran and Andorra). The single French Alpine chamois sequence clustered in BDV-6 ovine genetic group as recently reported [19]. …”

Section: Resultssupporting

confidence: 66%

“…A total of 51 chamois BDV sequences were available, 10 of which were novel Pyrenean chamois sequences and 41 were retrieved from public database, encompassing an alignment of 234 nucleotides (http://www.ncbi.nlm.nih.gov/nuccore/?term=pestivirus+chamois, accessed last time at 29-2-2016). On the whole, 50 sequences were from Pyrenean chamois and one from Alpine chamois, identified in French Alps [19], and the sampling dates ranged from 1996 to 2011.…”

Section: Methodsmentioning

confidence: 99%

“…In respect to BDV in Alpine chamois ( R . rupicapra rupicapra) , the genetic variant circulating in sheep BDV-6 has been recently detected in a single animal in French Southern Alps, where the chamois population showed seroprevalence of 38.7% with no mortality or clinical diseases [19]. Moreover a genetic variant of livestock origin has been observed in a comprehensive investigation on wild ruminants in Switzerland, with a sporadic frequency of infections detecting a single chamois BVDV-1h positive [20].…”

Section: Introductionmentioning

confidence: 99%

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Spatial and Temporal Phylogeny of Border Disease Virus in Pyrenean Chamois (Rupicapra p. pyrenaica)

et al. 2016

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Border disease virus (BDV) affects a wide range of ruminants worldwide, mainly domestic sheep and goat. Since 2001 several outbreaks of disease associated to BDV infection have been described in Pyrenean chamois (Rupicapra pyrenaica pyrenaica) in Spain, France and Andorra. In order to reconstruct the most probable places of origin and pathways of dispersion of BDV among Pyrenean chamois, a phylogenetic analysis of 95 BDV 5’untranslated sequences has been performed on chamois and domestic ungulates, including novel sequences and retrieved from public databases, using a Bayesian Markov Chain Monte Carlo method. Discrete and continuous space phylogeography have been applied on chamois sequences dataset, using centroid positions and latitude and longitude coordinates of the animals, respectively.The estimated mean evolutionary rate of BDV sequences was 2.9×10−3 subs/site/year (95% HPD: 1.5–4.6×10−3). All the Pyrenean chamois isolates clustered in a unique highly significant clade, that originated from BDV-4a ovine clade. The introduction from sheep (dated back to the early 90s) generated a founder effect on the chamois population and the most probable place of origin of Pyrenean chamois BDV was estimated at coordinates 42.42 N and 1.9 E. The pathways of virus dispersion showed two main routes: the first started on the early 90s of the past century with a westward direction and the second arise in Central Pyrenees. The virus spread westward for more than 125 km and southward for about 50km and the estimated epidemic diffusion rate was about 13.1 km/year (95% HPD 5.2–21.4 km/year). The strong spatial structure, with strains from a single locality segregating together in homogeneous groups, and the significant pathways of viral dispersion among the areas, allowed to reconstruct both events of infection in a single area and of migrations, occurring between neighboring areas.

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Section: Resultssupporting

confidence: 66%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Spatial and Temporal Phylogeny of Border Disease Virus in Pyrenean Chamois (Rupicapra p. pyrenaica)

et al. 2016

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“…In these studies, the higher prevalence of pestivirus antibodies in sympatric sheep (seroconversion in alpine meadows) as well as the relatively frequent detection of PI sheep (Krametter-Froetscher and others 2007, Braun and others 2013) indicate pestivirus transmission from livestock to chamois (Vilček and Nettleton 2006). In fact, a BDV isolated from a chamois was similar to sequences of local sheep strains in the French Alps (Martin and others 2015). As those previous reports, the pestivirus exposure in both chamois and sheep in this study was similar with low seroprevalence and suggests a putative epidemiological link between these two ruminant species, which warrants further research.…”

Section: Discussionmentioning

confidence: 85%

“…In this sense, high seroprevalences have been reported in sheep grazing in alpine meadows of the Austrian (83 per cent), French (76.5 per cent) and Italian (90 per cent) Alps and Spanish Pyrenees (23–69 per cent) (Gaffuri and others 2006, Krametter-Froetscher and others 2007, Marco and others 2009a, Fernández-Sirera and others 2012a, Martin and others 2015) and relatively high seroprevalence has also been observed for several consecutive years in chamois from French (42 per cent) and Italian (18–42 per cent) Alps (Olde Riekerink and others 2005, Gaffuri and others 2006, Martin and others 2011, 2015, Fernández-Sirera and others 2012). In these studies, the higher prevalence of pestivirus antibodies in sympatric sheep (seroconversion in alpine meadows) as well as the relatively frequent detection of PI sheep (Krametter-Froetscher and others 2007, Braun and others 2013) indicate pestivirus transmission from livestock to chamois (Vilček and Nettleton 2006).…”

Section: Discussionmentioning

confidence: 98%

Pestivirus in alpine wild ruminants and sympatric livestock from the Cantabrian Mountains, Spain

et al. 2016

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Bovine viral diarrhoea virus (BVDV) and Border disease virus (BDV) were investigated at the wildlife-livestock interface in the distribution area of chamois in the Cantabrian Mountains, North-Western Spain. From 2010 to 2014, sera from sympatric wild (n=167) and domestic (n=272) ruminants were analysed for pestivirus antibodies by cELISA, virus neutralisation test (VNT) and for the presence of pestiviral RNA using a reverse transcription (RT)-PCR. Results showed a higher seroprevalence in cattle (59.4 per cent, 13/13 of herds) than in domestic small ruminants (5.9 per cent sheep, 2/8 of flocks; 0 per cent goats of 4 flocks) and wildlife (10.8 per cent in red deer, 0 per cent in roe deer and 0 per cent in Cantabrian chamois). High VNT titres were detected in two cattle herds, suggesting the circulation of BVDV-1 and BVDV-2 strains. BVDV-1 RNA was detected in one cattle calf by RT-PCR and sequencing. Conversely to other similar grazing systems, sheep flocks did not play a relevant role in the pestivirus epidemiology in this region. Pestivirus infections in wild ruminants were sporadic and most probably dependent on a domestic source.

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Abortive diseases and their various associated risk factors in small ruminants in Algeria: a systematic review

Haif¹,

Khelifi-Ouchene

Khelifi

et al. 2021

Trop Anim Health Prod

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Pestiviruses infections at the wild and domestic ruminants interface in the French Southern Alps

Cited by 21 publications

References 29 publications

Spatial and Temporal Phylogeny of Border Disease Virus in Pyrenean Chamois (Rupicapra p. pyrenaica)

Spatial and Temporal Phylogeny of Border Disease Virus in Pyrenean Chamois (Rupicapra p. pyrenaica)

Pestivirus in alpine wild ruminants and sympatric livestock from the Cantabrian Mountains, Spain

Abortive diseases and their various associated risk factors in small ruminants in Algeria: a systematic review

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