Pestivirus as a cause of white matter damage -down but not out

Rennie, J. K.; Peebles, Donald

doi:10.1017/s0012162206000533

Cited by 4 publications

(3 citation statements)

References 9 publications

(7 reference statements)

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“…In the USA 40% of sera from identical twins discordant for schizophrenia tested positive for specific anti-BVDV antibodies (26). Infection during pregnancy and a possible association with some forms of cerebral White Matter Damage (WMD) in preterm neonates have been investigated (27). Animal and herd infection by BVDV in the State of Paraíba, Brazil have been reported.…”

Section: Main Textmentioning

confidence: 99%

Zika virus may not be alone: proteomics associates a bovine-like viral diarrhea virus to microcephaly

Nogueira

Velásquez

Melo³

et al. 2016

Preprint

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One Sentence Summary:Proteomics analysis lead us to suspect the presence of a Bovine-like viral diarrhea virus (BVDV-like) in the brain tissue of fetuses bearing microcephaly during the outbreak in Paraíba State, Brazil, 2015. AbstractNo direct experimental causal evidence confirms that the Zika virus is the sole etiological agent responsible for the development of brain malformations in human fetuses during pregnancy. We used a discovery-driven approach to analyze protein extracts of three Zika positive brains. Shotgun mass spectrometry (MS) proteomics did not identify any Zika protein in all samples. However, MS detected the presence of peptide(s) from the polyprotein of a Bovine-like viral diarrhea virus (BVDV-like) in Zika-positive brains. These results indicate that Zika virus may not be, per se, the only etiological agent responsible for microcephaly and suggests that discovery-driven approaches play an essential role in the screening of fluids or tissues for virus or other etiological agents. MAIN TEXTTo the Zika infection in Bahia, Brazil in 2015 (1) followed a dramatic outbreak of microcephaly in the Northeastern Brazilian States of Paraíba, Pernambuco and Bahia (2). In January 2016, Melo suggested a correlation between Zika infection and fetal microcephaly during a two case study of women living in Paraiba State who complained of symptoms of Zika virus infection during pregnancy; real time PCR confirmed the presence of Zika virus in children brain tissue and amniotic fluid (3). Other groups associated the presence of Zika virus to microcephaly (4) and reviewed the evidence for causality by several criteria (5). However, reports linking high incidence of human microcephaly to the presence of Zika virus do not disclose any experimental data that provide a direct link between microcephaly and Zika virus during fetal brain development in spite of reducing viability and growth of neurospheres and brain organoids (6). Here, we expand these findings using discovery-driven shotgun . CC-BY-NC-ND 4.0 International license peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/062596 doi: bioRxiv preprint first posted online Jul. 15, 2016; proteomics based on high resolution and accuracy mass spectrometry analysis to show the detection of a BVDV-like virus in tissue extracts of Zika positive brains. Microcephaly is associated with genetic disorders. Among others, chromosomal trisomy (Edward´s), Aicardi-Goutieres´ and Rett´s syndromes and X-chromosomal microcephaly and trans-placental infections by viruses or bacteria, including rubella, cytomegalovirus, herpes simplex, varicella zoster virus, HIV, arboviruses and maternal malnutrition or drug use and chemical intoxication of pregnant mothers (3-5, 7).Reports disclosed the incidence of Central Nervous System (CNS) malformations in fetuses and neonates after the Zika virus outbreak in French Polynesia; however, incidence of microcephaly associated with the outbreak was n...

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Section: Main Textmentioning

confidence: 99%

Zika virus may not be alone: proteomics associates a bovine-like viral diarrhea virus to microcephaly

Nogueira

Velásquez

Melo³

et al. 2016

Preprint

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“…In the USA, antibodies against BVDV were detected in mothers with microcephalic infants ( Potts et al ., 1987 ) and in 40% of sera from identical twins discordant for schizophrenia ( Yolken et al ., 1993 ). Infection during pregnancy and cerebral white matter damage in preterm neonates have also been explored ( Dammann and Leviton, 1998 , 2004 ; Leviton et al ., 2005 ; Dammann et al ., 2006 ; Rennie and Peebles, 2006 ). Most of the studies were based on serological screening, and some have been conducted to reveal antigens.…”

Section: Discussionmentioning

confidence: 99%

Serological survey on Bovine viral diarrhea virus in man and evaluation of relation with Zika virus associated microcephaly

Giangaspero¹,

Okabayashi²

2023

Open Vet J

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Background: In 2015, an unprecedented epidemic of microcephaly occurred in Brazil. Preliminary observations suggested involvement of cofactors in the etiopathology of Zika virus associated microcephaly. Bovine viral diarrhea virus (BVDV) was identified in fetal samples with microcephaly, originating in the state of Paraíba, and two virus sequences, obtained from the amniotic fluid collected from mothers with babies affected by Zika and microcephaly, have been characterized as two different species of BVDV, types 1 and 2. Aim: The involvement of BVDV as co-factor in the etiopathogenesis of Zika virus associated microcephaly was explored. Methods: A serological screening using an ELISA test was undertaken to detect antibodies against BVDV among patients referred to the Central laboratory of Natal, Rio Grande do Norte, encompassing microcephalic babies and their mothers, mothers and pregnant not associated with microcephaly and general patients as control group. Results: Two samples were positive, out of 382 tested, (0.52%). No specific relation with birth-defects could be established. Conclusion: The study might suggest serological evidence of the circulation of BVDV in humans. Further studies and application of improved diagnostic tests adapted to humans are necessary to clarify the epidemiological extent and impact of BVDV.

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“…Other studies suggested a link between Pestivirus and neurological disorders in humans. Infection during pregnancy and a possible association with some forms of cerebral White Matter Damage (WMD) in preterm neonates have been investigated [47][48][49][50][51].…”

Section: Introductionmentioning

confidence: 99%

Pestivirus Species Potential Adventitious Contaminants of Biological Products

Giangaspero¹

2013

Trop Med Surg

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Pestivirus as a cause of white matter damage -down but not out

Cited by 4 publications

References 9 publications

Zika virus may not be alone: proteomics associates a bovine-like viral diarrhea virus to microcephaly

Zika virus may not be alone: proteomics associates a bovine-like viral diarrhea virus to microcephaly

Serological survey on Bovine viral diarrhea virus in man and evaluation of relation with Zika virus associated microcephaly

Pestivirus Species Potential Adventitious Contaminants of Biological Products

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