Pesticides in blood

Schäfer, Mary L.

doi:10.1007/978-1-4615-8440-7_2

Cited by 7 publications

(4 citation statements)

References 22 publications

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“…Harrison and Shanks (1965) reported that DDT residues attained maximum levels in sheep fat about 2 weeks after sheep were exposed to a single oral dose of DDT or to DDT in the feed. These data support the suggestion by Schafer (1968) that blood levels of dieldrin (and DDT) probably reflect bot~ the initial absorption of these chemicals and their redistribution in vivo in favour of the fat. Theoretically therefore.…”

Section: Discussionsupporting

confidence: 89%

Metabolism of DDE, DDD, and DDT in sheep

Hunnego¹,

Harrison²

1971

New Zealand Journal of Agricultural Research

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Sheep were dosed orally for 28 consecutive days with DDE, DDD, or DDT individually, or with a mixture of these three compounds. In a second similar trial DDE was administered either alone or simultaneously with DDD and/or DDT. The dose rate for each compound in all cases was 1 mg pp'-isomer/kg body weight/day. All sheep were sampled for blood and omental fat during the dosing period and the following year.Maximum concentrations determined in fat were in the order DDE > DDD > DDT in the approximate ratios 10: 2: 1. Rates of elimination from fat when dosing was stopped were in the order DDD >DDT >DDE, the half-life being 4, 9, and 14 weeks respectively. In fat, DDE appeared as a metabolite of DDD and DDT, and DDD as a metalobite of DDT. In the first trial the simultaneous administration of DDD and DDT with DDE appeared to stimulate the subsequent elimination of DDE from storage in fat, but this effect was not reproduced in the second trial. There was a correlation between DDE in fat (mg/kg = x) and DDE in whole blood (/Lg/kg = y) expressed by the regression equation.x = 1.8y-l.l A sheep was given one oral dose of DDE, DDD, and DDT simultaneously, each at the rate of 50 mg/kg body weight. Highest concentrations of DDT and DDE occurred in blood 15 hours and 32 hours respectively after dosing. DDD showed two maxima, at 8 hours and at 32 hours after dosing.The value of blood and fat analyses for diagnostic purposes is discussed in relation to the results of these trials.

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Section: Discussionsupporting

confidence: 89%

Metabolism of DDE, DDD, and DDT in sheep

Hunnego¹,

Harrison²

1971

New Zealand Journal of Agricultural Research

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“…Mammalian blood and various organs have organophosphate-detoxifying enzymes (ZECH and ZURCHER 1974); however, the reported Km values for these enzymes (3 to 20xlO-4 M) are relatively poor in comparison to certain bacterial organosphosphate hydrolyzing enzymes (1.0 to 3.0x 10-5 M) (MuNNECKE 1977). Thus, it may be possible to have a much higher rate of pesticide hydrolysis by immobilized microbial enzymes in comparison to the in vivo systems due to the differences in substrate affinity at the relatively low pesticide concentrations found in poisoning cases (BARNES and DAVIES 1951, DAVIES et al 1975, SCHAFER 1968.…”

Section: D) Enzymatic Treatmentmentioning

confidence: 95%

Chemical, physical, and biological methods for the disposal and detoxification of pesticides

Munnecke¹

1979

Residue Reviews

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“…Colabium ct nl,, 1951Tipton anJ Cook, 1961Perry, 1968I'errv et ill. , 1962Tipton anil Cook, 1963 Patient* with lynphoaatou* dlaeaaea Koch et al, 1957Horry, 1968 Parry et al, Sudden accident victim*, male, up to 56 yearn old Koch *t al., Perry and Perry, 1959Perry and Perry, 1959Renloul and Smith, 1962Tipton at al. , 1969Koch et al, 1956 V*- 1968Koch et al, 1956Perry et al,, 1962 Scliroedur it al , , I960 Alexander and NdHKh-iunt, lit*,'…”

Section: Referencementioning

confidence: 99%