Pesticides and asthma

Hernández, Antonio F.; Parrón, Tesifón; Alarcón, Raquel

doi:10.1097/aci.0b013e3283445939

Cited by 129 publications

(94 citation statements)

References 42 publications

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“…According to this review, the main mechanism lies in the neurogenic inflammation induced by contact with pesticides in agricultural populations. In the case of asthma induced by organophosphates, the problem seems to be a dysfunction in muscarinic M2 receptors, which are normally used to limit the release of acetylcholine esterase by parasympathetic fibres [69].…”

Section: Discussionmentioning

confidence: 99%

Occupational exposure to pesticides and respiratory health

et al. 2015

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This article aims to review the available literature regarding the link between occupational exposure to pesticides and respiratory symptoms or diseases. Identification of epidemiological studies was performed using PubMed. 41 articles were included, 36 regarding agricultural workers and five regarding industry workers.Among the 15 cross-sectional studies focusing on respiratory symptoms and agricultural pesticide exposure, 12 found significant associations with chronic cough, wheeze, dyspnoea, breathlessness or chest tightness. All four studies on asthma found a relationship with occupational exposure, as did all three studies on chronic bronchitis. The four studies that performed spirometry reported impaired respiratory function linked to pesticide exposure, suggestive of either obstructive or restrictive syndrome according to the chemical class of pesticide.12 papers reported results from cohort studies. Three out of nine found a significant relationship with increased risk of wheeze, five out of nine with asthma and three out of three with chronic bronchitis. In workers employed in pesticide production, elevated risks of chronic obstructive pulmonary disease (two studies out of three) and impaired respiratory function suggestive of an obstructive syndrome (two studies out of two) were reported.In conclusion, this article suggests that occupational exposure to pesticides is associated with an increased risk of respiratory symptoms, asthma and chronic bronchitis, but the causal relationship is still under debate. @ERSpublications A review of occupational (agricultural and industry) exposure to pesticides and associated respiratory health effects http:///ow.ly/M09Gc

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Section: Discussionmentioning

confidence: 99%

Occupational exposure to pesticides and respiratory health

et al. 2015

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“…Recently, HERNÁNDEZ et al [15] have drawn attention to experimental studies suggesting a potential relationship between induced airway hyperreactivity in allergic asthma and pesticide exposure. PROSKOCIL et al [16] have reported a lower potentiated vagally induced bronchoconstriction threshold in allergen sensitised guinea pigs, and increased production of proinflammatory cytokines in guinea pigs induced by organophosphate insecticides [17].…”

Section: Introductionmentioning

confidence: 99%

Environmental exposure to pesticides and respiratory health

et al. 2015

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Respiratory effects of environmental exposure to pesticides are debated. Here we aimed to review epidemiological studies published up until 2013, using the PubMed database. 20 studies dealing with respiratory health and non-occupational pesticide exposure were identified, 14 carried out on children and six on adults.In four out of nine studies in children with biological measurements, mothers' dichlorodiphenyldichloroethylene (DDE) blood levels during pregnancy were associated with asthma and wheezing in young children. An association was also found between permethrin in indoor air during pregnancy and wheezing in children. A significant association between asthma and DDE measured in children's blood (aged 7-10 years) was observed in one study. However, in three studies, no association was found between asthma or respiratory infections in children and pesticide levels in breast milk and/or infant blood. Lastly, in three out of four studies where post-natal pesticide exposure of children was assessed by parental questionnaire an association with respiratory symptoms was found. Results of the fewer studies on pesticide environmental exposure and respiratory health of adults were much less conclusive: indeed, the associations observed were weak and often not significant.In conclusion, further studies are needed to confirm whether there is a respiratory risk associated with environmental exposure to pesticides. @ERSpublications Occupational pesticide exposure increases respiratory health risk but data are unclear for environmental exposures http://ow.ly/PSGvz

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“…The frequent use of bleach (hypochlorite), ammonia, and degreasing sprays has been consistently associated with asthma among workers exposed to cleaning agents (42,44,48), although the precise chemical exposures and the mechanisms responsible for the increased incidence of asthma have not been clarified since cleaning materials typically contain a wide variety of ingredients, some of which are respiratory irritants, while others are potential airway sensitizers (Table 6). Other occupations associated with increased risk of asthma that cannot be readily or completely explained on the basis of a clear sensitizing exposure are presented in Table 6 (47,(49)(50)(51)(52)(53)(54)(55)(56).…”

Section: Epidemiological Evidence For Irritant-induced Asthmamentioning

confidence: 99%

EAACI position paper: irritant‐induced asthma

Vandenplas

Wiszniewska

Raulf

et al. 2014

Allergy

121

108

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The term irritant-induced (occupational) asthma (IIA) has been used to denote various clinical forms of asthma related to irritant exposure at work. The causal relationship between irritant exposure(s) and the development of asthma can be substantiated by the temporal association between the onset of asthma symptoms and a single or multiple high-level exposure(s) to irritants, whereas this relationship can only be inferred from epidemiological data for workers chronically exposed to moderate levels of irritants. Accordingly, the following clinical phenotypes should be distinguished within the wide spectrum of irritant-related asthma: (i) definite IIA, that is acute-onset IIA characterized by the rapid onset of asthma within a few hours after a single exposure to very high levels of irritant substances; (ii) probable IIA, that is asthma that develops in workers with multiple symptomatic high-level exposures to irritants; and (iii) possible IIA, that is asthma occurring with a delayed-onset after chronic exposure to moderate levels of irritants. This document prepared by a panel of experts summarizes our current knowledge on the diagnostic approach, epidemiology, pathophysiology, and management of the various phenotypes of IIA.Abbreviations IIA, irritant-induced asthma; NSBH, nonspecific bronchial hyperresponsiveness; OA, occupational asthma; RADS, reactive airways dysfunction syndrome; TRP, transient receptor potential.

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Pesticides and asthma

Cited by 129 publications

References 42 publications

Occupational exposure to pesticides and respiratory health

Occupational exposure to pesticides and respiratory health

Environmental exposure to pesticides and respiratory health

EAACI position paper: irritant‐induced asthma

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