Pesticide intoxications in Cukurova, Turkey: three years analysis

Dağlioğlu, Nebīle; Akçan, Ramazan; Gülmen, Mete Korkut; Yener, Fadile; Efeoglu, Pinar

doi:10.1177/0960327111402241

Cited by 9 publications

(3 citation statements)

References 16 publications

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“…This observation is in agreement with previous studies from Epirus , other Greek regions , and other countries . The main classes of pesticides were the same as in other Mediterranean regions .…”

Section: Discussionsupporting

confidence: 93%

Fatal Intoxications in a Forensic Autopsy Material from Epirus, Greece, During the Period 1998‐2010

Boumba

Georgiadis

Mirescu

et al. 2012

Journal of Forensic Sciences

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In this retrospective study, we report the epidemiological characteristics of all poisoning deaths in Epirus, Greece, from 1998 to 2010; we present the toxicological findings and the statistical evaluation of the results. This is the first detailed scientific report on all the officially certified poisoning deaths concerning part of the Greek population. A total of 126 poisoning fatalities were recorded, 67 of them being mono-intoxications (53.2%). The cause of poisoning was as follows: drugs of abuse (60%); carbon monoxide (19.8%); pesticides (9.5%); corrosives (4.8%); pharmaceuticals (4.8%); and spider bite (0.8%). The most frequently detected poisonous substances were as follows: heroin (65 cases), ethanol (55), benzodiazepines (42), carbon monoxide (25), cocaine (17), cannabinoids (17) and pesticides (12). Increasing tendency in poisoning death rates was recorded, due to an increase in accidental poisoning deaths attributed mainly to drugs of abuse (total, accidental, and drugs-of-abuse poisoning death rates per 100,000 inhabitants per year were 1.87, 1.19, and 0.79, respectively, in the period 1998-2002 and 3.97, 3.41, and 2.55, respectively, in the period 2007-2010).

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Section: Discussionsupporting

confidence: 93%

Fatal Intoxications in a Forensic Autopsy Material from Epirus, Greece, During the Period 1998‐2010

Boumba

Georgiadis

Mirescu

et al. 2012

Journal of Forensic Sciences

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“…Residues of OCPs have been found in human tissues all over the World. 19,21,22 Some of these compounds resemble 17β-oestradiol (E 2 ) in terms of chemical structure and thus can bind to ER and mimic the effects of the endogenous ligand. Some xenohormones may display anti-estrogenic actions by binding to AHR and initiating transcription of cytochrome p450 enzymes that metabolise E 2 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of estrogenic effects of polychlorinated biphenyls and organochlorinated pesticides using immature rat uterotrophic assay

et al. 2013

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In this study, we investigated the effects of polychlorinated biphenyls (PCBs) and organochlorinated pesticides on the serum levels of luteinising hormone (LH), follicle stimulating hormone (FSH) and weights and histomorphometry of uterine tissue in immature female rats using uterotrophic assay. A total of 36 rats were randomly divided into six groups (n = 6 per group) as control, oestradiol (E2, 100 μg/kg), PCB 180, Aroclor 1221, endosulfan and mirex at 10 mg/kg dosage. After 3 days of injections (subcutaneous), animals were decapitated and blood samples were collected. Uteri were dissected, weighed out and then fixed in 10% formaldehyde. They were processed for histomorphometry. The serum levels of LH and FSH were determined by enzyme immunoassay. Uterine weight was significantly increased by E2 and reduced by mirex (p < 0.001 and p < 0.05, respectively). Total volume of uterus was significantly raised by E2, Aroclor 1221 and endosulfan compared with that of the control group (p < 0.01). The ratio of epithelium was significantly increased by E2, PCBs and pesticides (p < 0.01). The uterine cavity ratio was decreased by aroclor (p < 0.01), PCB 180 and mirex (p < 0.05). The serum levels of LH did not significantly differ among the groups but the levels of FSH were decreased by PCB 180 and endosulfan (p < 0.05 and p < 0.01, respectively). These findings suggest that PCB 180, Aroclor 1221 and endosulfan may be estrogenic in immature uterotrophic assay.

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“…A recent study in our region has shown that the cukurova region is the most important agricultural area and is responsible for 32% pesticide use in Turkey [16]. As a consequence of this wide pesticide use, acute pesticide poisoning cases are quite common in this region.…”

Section: Discussionmentioning

confidence: 90%

Chromosomal Aberrations in agricultural farmers exposed to pesticides

Demırhan¹,

Akbaba²,

Çelik³

et al. 2019

Adv Toxicol Toxic Effects

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Pesticides which constitute an group of environmental pollutants are commonly used in agriculture to protect crops. Pesticide exposure may be associated with increased risk of genotoxicity and carcinogenesis. Therefore, they pose a potential risk to farmers and environment. The aim of the present study is to investigate whether occupational exposure to various pesticides causes Chromosomal Aberrations (CAs) in agricultural farmers. The frequency of CAs in peripheral blood lymphocytes were evaluated in 35 Agricultural Farmers (AFs) and 40 control subjects living in Çukurova Region. The results showed that farmers exposed to pesticides had signifi cantly increased frequencies of CAs when compared with controls (P<0.05). Ageadjusted group comparisons showed that the frequency of CAs in the pesticide exposed AFs were 2,3 times higher than in the control group (OR: 2,3, 95% wald confi dence limits: 1,9-2,9). The confounding factors such as variable duration of pesticide exposure, age, smoking, alcohol consumption had no signifi cant effect on cytogenetic damage (P>0.05). Fragile sites (FSs) on the 1(q21-24), 1(q31-32), 2(q31-34), 2(q21-23), 3(p21), 3(p25) and 5(q31-q34) chromosomal regions were signifi cantly overexpressed in AFs, when compared to the control group (in 12.6% versus 4.3% of cells) (P<0.05). Our fi ndings indicate that occupational exposure to pesticides could cause cytogenetic damage in somatic cells of AFs. It is known that accumulation of CAs is a crucial step for initiation of many cancers. Therefore, it is suggested that the exposed workers should be warned about the potential harmful effects of pesticides and relevant authorities should safeguard that protective measures are taken by farmers while working in agricultural fi elds.

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Pesticide intoxications in Cukurova, Turkey: three years analysis

Cited by 9 publications

References 16 publications

Fatal Intoxications in a Forensic Autopsy Material from Epirus, Greece, During the Period 1998‐2010

Fatal Intoxications in a Forensic Autopsy Material from Epirus, Greece, During the Period 1998‐2010

Evaluation of estrogenic effects of polychlorinated biphenyls and organochlorinated pesticides using immature rat uterotrophic assay

Chromosomal Aberrations in agricultural farmers exposed to pesticides

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