Peste des Petits Ruminants Virus in Heilongjiang Province, China, 2014

Wang, Jingfei; Wang, Miao; Wang, Shida; Liu, Zaisi; Shen, Nan; Wei, Si; Sun, Gang; Drewe, Julian Ashley; Cai, Xuehui

doi:10.3201/eid2104.141627

Cited by 23 publications

(20 citation statements)

References 14 publications

(11 reference statements)

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“…N gene sequences of PPRV strains isolated from different animals in the farms of Zhambyl oblast have shown high nucleotide homology level (99.8–99.9%). Nucleotide sequence analysis has demonstrated that these Kazakhstan viruses are 99.8–100% identical to PPRV isolated in 2013 from the outbreak in Yili region of Xinjiang province in China (Bao et al., ) and 99.5–99.7% identical to the virus isolated in 2014 from the outbreak in Heilongjiang Province, China (Wang et al., ) (Fig. ).…”

Section: Resultsmentioning

confidence: 95%

“…Peste des petits ruminants (PPR), an acute viral infectious disease of domestic goats, sheep and some wild ruminants, is characterized by fever, ocular and nasal discharges, necrotic stomatitis, diarrhoea, pneumonia and death with significant mortality in naïve outbreaks (Kwiatek et al., ; Soltan and Abd‐Eldaim, ; Parida et al., ; Wang et al., ). Species of the family Caprinae are particularly susceptible to disease including several endangered mountain and desert ungulates (Abu‐Elzein et al., ; Sharawi et al., ; Abubakar et al., ; Hoffmann et al., ; Munir, ).…”

Section: Introductionmentioning

confidence: 99%

“…Peste des petits ruminant virus (PPRV) is a negative‐strand RNA virus, belongs to the genus Morbillivirus in the family Paramyxoviridae (Gibbs et al., ). Peste des petits ruminant was first described as an infection of sheep and goats in Cote‐d'Ivoire (Gargadennec and Lalanne, ), and since then, the virus has been confirmed across Africa, Asia and the European part of Turkey (Ozkul et al., ; Kwiatek et al., ; Banyard et al., ; Balamurugan et al., ; Anees et al., ; Muniraju et al., ; Soltan and Abd‐Eldaim, ; Wang et al., ). Peste des petits ruminant virus exists as a single serotype (Shaila et al., ) and on the basis of studying partial F and N gene sequences; PPR viruses are classified into four lineages (I, II, III and IV) that differ genetically (Ozkul et al., ; Kwiatek et al., ).…”

Section: Introductionmentioning

confidence: 99%

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Detection and Genetic Characterization of Lineage IV Peste Des Petits Ruminant Virus in Kazakhstan

Kock

Orynbayev

Sultankulova

et al. 2015

Transbound Emerg Dis

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Peste des petits ruminant (PPR) is endemic in many Asian countries with expansion of the range in recent years including across China during 2013-2014 (OIE, 2014). Till the end of 2014, no cases of PPR virus (PPRV) were officially reported to the Office Internationale des Epizooties (OIE) from Kazakhstan. This study describes for the first time clinicopathological, epidemiological and genetic characterization of PPRV in 3 farm level outbreaks reported for the first time in Zhambyl region (oblast), southern Kazakhstan. Phylogenetic analysis based on partial N gene sequence data confirms the lineage IV PPRV circulation, similar to the virus that recently circulated in China. The isolated viruses are 99.5-99.7% identical to the PPRV isolated in 2014 from Heilongjiang Province in China and therefore providing evidence of transboundary spread of PPRV. There is a risk of further maintenance of virus in young stock despite vaccination of adult sheep and goats, along livestock trade and pastoral routes, threatening both small livestock and endangered susceptible wildlife populations throughout Kazakhstan.

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Section: Resultsmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Detection and Genetic Characterization of Lineage IV Peste Des Petits Ruminant Virus in Kazakhstan

Kock

Orynbayev

Sultankulova

et al. 2015

Transbound Emerg Dis

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“…PPRV continues to spread globally [35], [36], with over 1 billion sheep and goats at risk from infection, approximately 80% of the world’s small ruminants [37]. RPV eradication led to the cessation of vaccination and, as a result, there are fears that morbilliviruses such as PPRV or CDV could spill over into the global population of 1.5 billion immunologically-naïve cattle [38].…”

Section: Discussionmentioning

confidence: 99%

Enhanced immunosurveillance for animal morbilliviruses using vesicular stomatitis virus (VSV) pseudotypes

Logan

Dundon

Diallo

et al. 2016

Vaccine

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The measurement of virus-specific neutralising antibodies represents the “gold-standard” for diagnostic serology. For animal morbilliviruses, such as peste des petits ruminants (PPRV) or rinderpest virus (RPV), live virus-based neutralisation tests require high-level biocontainment to prevent the accidental escape of the infectious agents. In this study, we describe the adaptation of a replication-defective vesicular stomatitis virus (VSVΔG) based pseudotyping system for the measurement of neutralising antibodies against animal morbilliviruses. By expressing the haemagglutinin (H) and fusion (F) proteins of PPRV on VSVΔG pseudotypes bearing a luciferase marker gene, neutralising antibody titres could be measured rapidly and with high sensitivity. Serological responses against the four distinct lineages of PPRV could be measured simultaneously and cross-neutralising responses against other morbilliviruses compared. Using this approach, we observed that titres of neutralising antibodies induced by vaccination with live attenuated PPRV were lower than those induced by wild type virus infection and the level of cross-lineage neutralisation varied between vaccinates. By comparing neutralising responses from animals infected with either PPRV or RPV, we found that responses were highest against the homologous virus, indicating that retrospective analyses of serum samples could be used to confirm the nature of the original pathogen to which an animal had been exposed. Accordingly, when screening sera from domestic livestock and wild ruminants in Tanzania, we detected evidence of cross-species infection with PPRV, canine distemper virus (CDV) and a RPV-related bovine morbillivirus, suggesting that exposure to animal morbilliviruses may be more widespread than indicated previously using existing diagnostic techniques.

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“…In December 2013, a new outbreak of PPR was reported in Xinjiang Province, and PPR was also detected in Gansu, Inner Mongolia, Ningxia, Jiangxi, and Hunan Provinces by mid-March 2014 (Wang et al, 2015). The ibex, also known as the Asian antelope, is under First-Grade State Protection in China, and primarily lives in groups distributed among the Xinjiang Tianshan Mountains, northwestern Gansu Province, and the northwestern Inner Mongolia Autonomous Region.…”

Section: Introductionmentioning

confidence: 99%

Sequence analysis of peste des petits ruminants virus from ibexes in Xinjiang, China

et al. 2016

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Peste des Petits Ruminants Virus in Heilongjiang Province, China, 2014

Cited by 23 publications

References 14 publications

Detection and Genetic Characterization of Lineage IV Peste Des Petits Ruminant Virus in Kazakhstan

Detection and Genetic Characterization of Lineage IV Peste Des Petits Ruminant Virus in Kazakhstan

Enhanced immunosurveillance for animal morbilliviruses using vesicular stomatitis virus (VSV) pseudotypes

Sequence analysis of peste des petits ruminants virus from ibexes in Xinjiang, China

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