Peste des Petits Ruminants Vaccine  (Nigerian Strain 75/1) Confers Protection for at Least 3 Years in Sheep and Goats

Zahur, Aamer Bin; Irshad, Hamid; Ullah, Aman; Afzal, Muhammad; Latif, Asma; Ullah, Riasat Wasee; Farooq, Umer; Samo, Muhammad Humayoon; Jahangir, Muhammad

doi:10.4236/jbm.2014.26005

Cited by 13 publications

(14 citation statements)

References 19 publications

(24 reference statements)

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“…Furthermore, vaccinated animals produce high amount of neutralizing antibodies against the H, F, and F proteins similar to those recovered from a natural infection [ 26 , 27 ]. In a report, a single immunization with PPR vaccine conferred solid protection in sheep and goats for 3 years [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

Assessment of immune response to a lyophilized peste-des-petitsruminants virus vaccine in three different breeds of goats

Begum¹,

Mahato²,

Sharma³

et al. 2016

Vet World

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Aim:Immune response to a lyophilized peste-des-petits-ruminants virus (PPRV) vaccine was evaluated in three different breeds of goats.Materials and Methods:Three breeds of goats consisting six number of animals in three groups, i.e., Group A (local Assam hill goat), Group B (cross-bred), and Group C (Beetal goats) were randomly selected for evaluating the immune response to a lyophilized PPRV vaccine.Results:A higher rise in the overall mean serum antibody titer was observed in Group A (40.50±3.74) than in Group B (37.58±37.58) and Group C (35.90±3.29) during the study period.Conclusion:Initially, a negative PPRV specific serum antibody titer was recorded in all the groups at 0th day of vaccination. Serum antibody titer in the vaccinated goats started rising gradually from the 14th day post vaccination. Later higher rise in the overall mean serum antibody titer in Group A (local Assam hill goat) lead to the conclusion that higher serum antibody titer in local non-descript breed might be due to their better adaptation to the environmental condition.

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Section: Resultsmentioning

confidence: 99%

Assessment of immune response to a lyophilized peste-des-petitsruminants virus vaccine in three different breeds of goats

Begum¹,

Mahato²,

Sharma³

et al. 2016

Vet World

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“…Because no new infection or additional vaccination were considered, and post-vaccination (or post-infection) immunity has a long persistence at the individual level: >> one year [10, 12, 54], this probability did not vary during the one-year simulations. Therefore: …”

Section: Methodsmentioning

confidence: 99%

Modelling the Dynamics of Post-Vaccination Immunity Rate in a Population of Sahelian Sheep after a Vaccination Campaign against Peste des Petits Ruminants Virus

2016

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BackgroundPeste des petits ruminants (PPR) is an acute infectious viral disease affecting domestic small ruminants (sheep and goats) and some wild ruminant species in Africa, the Middle East and Asia. A global PPR control strategy based on mass vaccination—in regions where PPR is endemic—was recently designed and launched by international organizations. Sahelian Africa is one of the most challenging endemic regions for PPR control. Indeed, strong seasonal and annual variations in mating, mortality and offtake rates result in a complex population dynamics which might in turn alter the population post-vaccination immunity rate (PIR), and thus be important to consider for the implementation of vaccination campaigns.MethodsIn a context of preventive vaccination in epidemiological units without PPR virus transmission, we developed a predictive, dynamic model based on a seasonal matrix population model to simulate PIR dynamics. This model was mostly calibrated with demographic and epidemiological parameters estimated from a long-term follow-up survey of small ruminant herds. We used it to simulate the PIR dynamics following a single PPR vaccination campaign in a Sahelian sheep population, and to assess the effects of (i) changes in offtake rate related to the Tabaski (a Muslim feast following the lunar calendar), and (ii) the date of implementation of the vaccination campaigns.ResultsThe persistence of PIR was not influenced by the Tabaski date. Decreasing the vaccination coverage from 100 to 80% had limited effects on PIR. However, lower vaccination coverage did not provide sufficient immunity rates (PIR < 70%). As a trade-off between model predictions and other considerations like animal physiological status, and suitability for livestock farmers, we would suggest to implement vaccination campaigns in September-October. This model is a first step towards better decision support for animal health authorities. It might be adapted to other species, livestock farming systems or diseases.

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“…In 2015, the Food and Agricultural Organization (FAO) and World Animal Health Organization (OIE) launched a global campaign to eradicate PPRV by 2030. Although the available, affordable vaccine has demonstrated protection for up to 3 years [2], the large, global small ruminant population turns over rapidly, increasing the difficulty of implementing control strategies, such as blanket mass vaccination. To better target eradication control efforts, FAO also launched a global PPRV research network in 2018 [3] with the goal of aligning research efforts to inform strategies for PPRV eradication.…”

Section: Introductionmentioning

confidence: 99%

Identifying Age Cohorts Responsible for Peste Des Petits Ruminants Virus Transmission among Sheep, Goats, and Cattle in Northern Tanzania

Herzog

Glanville

Willett

et al. 2020

Viruses

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Peste des petits ruminants virus (PPRV) causes a contagious disease of high morbidity and mortality in global sheep and goat populations. To better control this disease and inform eradication strategies, an improved understanding of how PPRV transmission risk varies by age is needed. Our study used a piece-wise catalytic model to estimate the age-specific force of infection (FOI, per capita infection rate of susceptible hosts) among sheep, goats, and cattle from a cross-sectional serosurvey dataset collected in 2016 in Tanzania. Apparent seroprevalence increased with age, reaching 53.6%, 46.8%, and 11.6% (true seroprevalence: 52.7%, 52.8%, 39.2%) for sheep, goats, and cattle, respectively. Seroprevalence was significantly higher among pastoral animals than agropastoral animals across all ages, with pastoral sheep and goat seroprevalence approaching 70% and 80%, respectively, suggesting pastoral endemicity. The best fitting piece-wise catalytic models merged age groups: two for sheep, three for goats, and four for cattle. The signal of these age heterogeneities were weak, except for a significant FOI peak among 2.5-3.5-year-old pastoral cattle. The subtle age-specific heterogeneities identified in this study suggest that targeting control efforts by age may not be as effective as targeting by other risk factors, such as production system type. Further research should investigate how specific husbandry practices affect PPRV transmission.

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Peste des Petits Ruminants Vaccine (Nigerian Strain 75/1) Confers Protection for at Least 3 Years in Sheep and Goats

Abstract: The present study reports the duration of immunity and protective efficacy of Peste des Petits Ruminants (

Cited by 13 publications

References 19 publications

Assessment of immune response to a lyophilized peste-des-petitsruminants virus vaccine in three different breeds of goats

Assessment of immune response to a lyophilized peste-des-petitsruminants virus vaccine in three different breeds of goats

Modelling the Dynamics of Post-Vaccination Immunity Rate in a Population of Sahelian Sheep after a Vaccination Campaign against Peste des Petits Ruminants Virus

Identifying Age Cohorts Responsible for Peste Des Petits Ruminants Virus Transmission among Sheep, Goats, and Cattle in Northern Tanzania

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