Assessment of immune response to a lyophilized peste-des-petitsruminants virus vaccine in three different breeds of goats

Begum, Safeeda Sultana; Mahato, G; Sharma, Paresh; Hussain, Manzoor; Saleque, A.

doi:10.14202/vetworld.2016.568-571

Cited by 9 publications

(5 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The disease burden was found to be significantly more in the Jamunapari breed than Black Bengal breed. Breed‐specific PPR susceptibility in small ruminants has also been reported by others (Begum, Mahato, Sharma, Hussain, & Saleque, ; Jalees, Hussain, Arshad, Mohammad, & Khan, ; Munir, ). We observed a 3.2 times greater odds of PPR in Jamunapari goats than in Black Bengals, which contrasts to other reports from Bangladesh (Rahman et al., ; Sarker & Islam, ).…”

Section: Discussionsupporting

confidence: 79%

Peste des Petits Ruminants risk factors and space-time clusters in Mymensingh, Bangladesh

Rony

Rahman

Alam

et al. 2017

Transbound Emerg Dis

View full text Add to dashboard Cite

Using a hospital-based case-control study design, our aim was to identify risk factors for-and space-time clusters of-Peste des Petits Ruminants (PPR) in Mymensingh, Bangladesh. Three hundred and eighty PPR cases diagnosed between January 2005 and December 2014 at the Bangladesh Agricultural University Veterinary Teaching Hospital (BAUVTH) were selected; three controls per case from BAUVTH were then selected (n = 1,048). From records, data extracted included information on date of report, location, age, breed, sex and body weight of goats. A mixed multivariable logistic regression model was built to identify risk factors. Location was included as a random effect and season and demographic variables as fixed effects. The approximate geographic coordinates of locations were collected, and the scan statistic (Bernoulli model) was used to identify space-time clusters of PPR. Compared with goats <4 months of age, the odds of PPR were 3 (95% confidence interval [CI]: 1.95-4.66), 1.9 (CI: 1.34-2.76) and 1.8 times (95% CI: 1.19-2.58) greater in goats aged 4-6, >6-12 and >12-24 months, respectively. The occurrence of PPR was also significantly higher (odds ratio [OR] 3.2; 95% CI: 1.15-8.59) in the Jamunapari breed than Black Bengals. Significantly higher odds of PPR were observed in winter (OR 1.6; 95% CI: 1.06-2.14) and the monsoon season (OR 1.5; 95% CI: 1.04-2.11) compared with the post-monsoon season. Two significant (p < .05) space-time clusters were identified between 2 December 2006 and 6 September 2007 (two locations) and 28 November 2006 and 13 February 2007 (five locations). Peste des Petits Ruminants is endemic in Bangladesh, but also occurs as discrete outbreaks. Control efforts-such as vaccination-should focus on high-risk groups (4-24 months of age, Jamunapari breed), prior to the onset of winter and the monsoon season so as to increase immunity during high-risk periods, and focus on disease hotspots.

show abstract

Section: Discussionsupporting

confidence: 79%

Peste des Petits Ruminants risk factors and space-time clusters in Mymensingh, Bangladesh

Rony

Rahman

Alam

et al. 2017

Transbound Emerg Dis

View full text Add to dashboard Cite

show abstract

“…In these studies, differences in the age at which kids should be vaccinated may be related to the types and breeds of experimental animals used in the studies. It has previously been proven that the same PPR vaccine can cause different immune responses in different breeds of goats [22].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Peste des Petits Ruminants Antibodies in Vaccinated Pregnant Ewes of Kazakh Breed Fine-Fleeced and Determination of the Decreasing Trend of Maternal Immunity in Their Lambs

Amanova,

Turyskeldy,

Kondybaeva

et al. 2023

Viruses

View full text Add to dashboard Cite

In this article, we first assessed peste des petits ruminants (PPR) antibodies in vaccinated pregnant ewes of Kazakh breed fine-fleeced immunized with the PPR vaccine and the duration of maternal immunity in their lambs. Ewes in the last trimester of pregnancy and gestation were immunized with a vaccine from the Nigeria 75/1 strain of the PPR virus (PPRV) produced by the Research Institute of Biological Safety Problems (RIBSP), Kazakhstan. Serum samples from lambs born from vaccinated and unvaccinated ewes were collected a week after birth and at intervals of 7 days for 18 weeks after birth. Serum samples collected from lambs were tested for PPR antibodies using competitive ELISA and virus neutralization test (VNT). Maternal antibodies (MAs) in lambs born from vaccinated ewes were detected for up to 18 weeks, with a tendency to decrease starting at week 14, and by the end of the experiment receded below the protective level (<1:8). In the blood serum of a 14-week-old lamb with MAs (1:8), post vaccination with a field dose (103 TCID50) of the vaccine against PPR, the titers of protective antibodies against PPRV increased to 1:16 on day 14 post vaccination, and the lamb was protected from infection with the field PPRV. A lamb of the same age with MAs in the 1:8 titer was 100% protected from infection with the field PPRV. Therefore, it is recommended that lambs of the Kazakh fine-wool breed be immunized from the age of 14 weeks or older to avoid a period of susceptibility.

show abstract

“…The shelf life of live-attenuated PPRV vaccine is 1 year at 4 C (Sen et al, 2010). Since the PPRV vaccine is mostly required for use in hot and humid climate in South Asia and Africa (Begum et al, 2016), therefore, maintenance of cold chain is essentially required for transportation of the vaccine in the field which significantly increases the overall cost of vaccine package. To circumvent the problem of cold chain maintenance, a range of improved freeze-drying methods have been developed to enhance the thermostabilty of the PPR vaccine.…”

Section: Thermo-stable Pprv Vaccinesmentioning

confidence: 99%

Advances in peste des petits ruminants vaccines

Kumar

Barua

Riyesh

et al. 2017

Veterinary Microbiology

View full text Add to dashboard Cite

Peste des petits ruminants (PPR) is a highly contagious disease of small ruminants that leads to high morbidity and mortality thereby results in devastating economic consequences to the livestock industry. PPR is currently endemic across most parts of Asia and Africa, the two regions with the highest concentration of poor people in the world. Sheep and goats in particularly contribute significantly towards the upliftment of livelihood of the poor and marginal farmers in these regions. In this context, PPR directly affecting the viability of sheep and goat husbandry has emerged as a major hurdle in the development of these regions. The control of PPR in these regions could significantly contribute to poverty alleviation, therefore, the Office International des Epizooties (OIE) and Food and Agricultural Organization (FAO) have targeted the control and eradication of PPR by 2030 a priority. In order to achieve this goal, a potent, safe and efficacious live-attenuated PPR vaccine with long-lasting immunity is available for immunoprophylaxis. However, the live-attenuated PPR vaccine is thermolabile and needs maintenance of an effective cold chain to deliver into the field. In addition, the infected animals cannot be differentiated from vaccinated animals. To overcome these limitations, some recombinant vaccines have been developed. This review comprehensively describes about the latest developments in PPR vaccines.

show abstract

Assessment of immune response to a lyophilized peste-des-petitsruminants virus vaccine in three different breeds of goats

Cited by 9 publications

References 26 publications

Peste des Petits Ruminants risk factors and space-time clusters in Mymensingh, Bangladesh

Peste des Petits Ruminants risk factors and space-time clusters in Mymensingh, Bangladesh

Assessment of Peste des Petits Ruminants Antibodies in Vaccinated Pregnant Ewes of Kazakh Breed Fine-Fleeced and Determination of the Decreasing Trend of Maternal Immunity in Their Lambs

Advances in peste des petits ruminants vaccines

Contact Info

Product

Resources

About