Pertussis Prevalence in Korean Adolescents and Adults with Persistent Cough

Lee, Soo‐Young; Han, Seung Beom; Kang, Jin Han; Kim, Ju Sang

doi:10.3346/jkms.2015.30.7.988

Cited by 20 publications

(25 citation statements)

References 13 publications

(22 reference statements)

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“…There was no significant difference in cough duration between pediatric adolescents and adults (Figure 3; p=0.711); the cough duration for patients diagnosed with pertussis was 7 days on median, 8.48 days on average, which was less than that in previous studies [6,7,15]. In this study, we 9 retrospectively analyzed the clinical symptoms of patients diagnosed with pertussis.…”

Section: Discussionmentioning

confidence: 79%

“…In addition, most adolescents do not receive regular booster vaccines; it has been reported that the probability of pertussis as a cause of chronic cough has increased [7]. Furthermore, pertussis infection in adolescents and adults has been found to be responsible for household transmission of pertussis to susceptible infants [19].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it is evident that the pertussis outbreak is not properly controlled. The reason for this includes non-immunization in adolescents and adults aged ≥ 15 years in a timely manner and underdiagnosis due to atypical symptoms in adolescents and adults [3,7]. Thus, such patients are the major cause of transmission within their families.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of rapid multiplex polymerase chain reaction for early diagnosis and treatment of pertussis

Park

Hur

et al. 2019

Preprint

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Background Pertussis, a highly infectious respiratory disease caused by Bordetella pertussis, causes airway inflammation and severe, persistent (lasting 2 weeks or more) characteristic whooping cough. In severe cases, complications such as atelectasis and bronchopneumonia may occur. Recently, the prevalence of pertussis has increased in South Korea due to reduced effect of the DTaP vaccination in infants as their age increased. Although culture is the gold standard test for diagnosis, polymerase chain reaction (PCR) method is most commonly used for diagnosis of pertussis due to the low sensitivity and long turnaround time of the culture method. Recently, a rapid multiplex PCR test has been introduced for comprehensive detection of respiratory pathogens (17 viruses and 3 bacteria), including Bordetella pertussis, with a turnaround time of 1 hour. This study aimed to investigate the efficacy of multiplex PCR for early diagnosis and treatment of pertussis. Methods We performed a retrospective study on patients with pertussis diagnosed from May 2017 to June 2019 at Yeungnam University Hospital. Nasopharyngeal swab specimens were tested using multiplex PCR. Medical records collected included data on age, sex, symptoms at the time of diagnosis, admission, hospitalization, isolation, vaccination history, past medical history, and accompanying diseases. Results A total of 27 patients were diagnosed with pertussis, nine (33.3%) of whom were men, with a median age of 48.9 years (3.3–82.2). Eleven (40.7%) had fever, 12 (44.4%) had dyspnea, 3 (11.1%) had paroxysmal cough, and 9 (33.3%) had inspiratory whooping. Seventeen (62.9%) and 24 (88.8%) patients had coughing for <8 days and ≤14 days, respectively. Median time from first symptom to diagnosis was 9.0 (1–31) days. Twenty-four patients (81.5%) were diagnosed within 2 weeks. All but one patient was prescribed macrolide antibiotics; all patients were isolated, with 22 (81.5%) requiring hospitalization. Three patients (11.1%) received ICU care for ventilation. All patients survived. Conclusion A rapid multiplex PCR test can ensure early diagnosis, isolation, and treatment of pertussis. Testing of patients with respiratory symptom with multiplex PCR can led to early diagnosis of pertussis, proper treatment, and may help in outbreak control.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efficacy of rapid multiplex polymerase chain reaction for early diagnosis and treatment of pertussis

Park

Hur

et al. 2019

Preprint

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“…In a multicenter study of 607 adult patients with bothersome cough (≥2 weeks) who were recruited from nonoutbreak, ordinary outpatient settings in 2009–2011, the positivity rate for pertussis on PCR was 0.7% [69]. In another study of 310 adolescent and adult patients with cough of 1- to 8-week duration (in Seoul and Incheon, 2009–2011), the pertussis positivity rate in culture, PCR, and serology tests was 1.0%, 3.2%, and 24.5%, respectively [70]. A case-control study found a positive association between acute Chlamydia pneumoniae infection and chronic cough [71].…”

Section: Common Comorbidities In Adult Patients With Chronic Cough Inmentioning

confidence: 99%

Chronic cough in Korean adults: a literature review on common comorbidity

Kang

Kim

Song

et al. 2016

Asia Pacific Allergy

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Chronic cough is a significant medical condition with high prevalence and a strong negative impact on the quality of life. Cough hypersensitivity is thought to underlie chronic cough, with several environmental and host factors interacting to cause neuronal sensitization and chronicity. Comorbid conditions affecting cough reflex pathways, such as upper airway diseases, asthma, and gastroesophageal reflux, play important roles in chronic cough. However, their prevalence may vary in patients living in different geographical regions or with different ethnicities. We conducted a literature review to examine common comorbidities in Korean adult patients with chronic cough, their clinical implications, and the issues that still need to be addressed in the development of clinical evidence of chronic cough in Korean adult patients.

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“…Із 76 хворих 20 становили підлітки, 56 - дорослі. З 2012 року в Кореї прийняте рішення щодо додаткової іму-нізації проти кашлюка підлітків віком 11-12 років [4]. У Сполучених Штатах Америки та Великобританії були висунуті основні гіпотези зростання числа випадків кашлюка внаслідок зниження імунітету як після вакцинації, так і після перенесеного захворювання через 8-11 років; еволюції Bordetella pertussis; низького рівня охоплення профілактичними щепленнями підлітків та дорослих осіб [5].…”

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Захворюваність На Кашлюк У Львівській Області

Іванченко¹

2021

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Pertussis Prevalence in Korean Adolescents and Adults with Persistent Cough

Cited by 20 publications

References 13 publications

Efficacy of rapid multiplex polymerase chain reaction for early diagnosis and treatment of pertussis

Efficacy of rapid multiplex polymerase chain reaction for early diagnosis and treatment of pertussis

Chronic cough in Korean adults: a literature review on common comorbidity

Захворюваність На Кашлюк У Львівській Області

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